Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, Mexico
Adolescents and young people are particularly vulnerable to contracting STIs, including HSV-2; furthermore, vaginal shedding of HSV-2 during pregnancy can cause vertical transmission and neonatal herpes. To evaluate the seroprevalence of HSV-2 and vaginal HSV-2 shedding in adolescent and young pregn...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/5/1122 |
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| author | Julio Cesar Muñiz-Salgado Gabriela Juárez-De la Cruz Dayana Nicté Vergara-Ortega Santa García-Cisneros María Olamendi-Portugal Miguel Ángel Sánchez-Alemán Antonia Herrera-Ortiz |
| author_facet | Julio Cesar Muñiz-Salgado Gabriela Juárez-De la Cruz Dayana Nicté Vergara-Ortega Santa García-Cisneros María Olamendi-Portugal Miguel Ángel Sánchez-Alemán Antonia Herrera-Ortiz |
| author_sort | Julio Cesar Muñiz-Salgado |
| collection | DOAJ |
| description | Adolescents and young people are particularly vulnerable to contracting STIs, including HSV-2; furthermore, vaginal shedding of HSV-2 during pregnancy can cause vertical transmission and neonatal herpes. To evaluate the seroprevalence of HSV-2 and vaginal HSV-2 shedding in adolescent and young pregnant women, a cross-sectional study was carried out in 496 pregnant women—adolescents and young women. Venous blood and vaginal exudate samples were taken. The seroprevalence of HSV-2 was determined by ELISA and Western blot. Vaginal HSV-2 shedding was assessed by qPCR of the HSV-2 UL30 gene. The seroprevalence of HSV-2 in the study population was 8.5% (95% CI 6–11), of which 38.1% had vaginal HSV-2 shedding (95% CI 22–53). Young women presented a higher seroprevalence of HSV-2 (12.1%) than adolescents (4.3%), OR = 3.4, 95% CI 1.59–7.23. Frequent alcohol consumption was significantly associated with HSV-2 seroprevalence, OR = 2.9, 95% CI 1.27–6.99. Vaginal HSV-2 shedding is highest in the third trimester of pregnancy, but this difference is not significant. The seroprevalence of HSV-2 in adolescents and young women is similar to that previously reported in other studies. However, the proportion of women with vaginal shedding of HSV-2 is higher during the third trimester of pregnancy, increasing the risk of vertical transmission. |
| first_indexed | 2024-03-11T03:14:59Z |
| format | Article |
| id | doaj.art-fa4888c74db24d97a7ac967fb93dd577 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T03:14:59Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-fa4888c74db24d97a7ac967fb93dd5772023-11-18T03:39:20ZengMDPI AGViruses1999-49152023-05-01155112210.3390/v15051122Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, MexicoJulio Cesar Muñiz-Salgado0Gabriela Juárez-De la Cruz1Dayana Nicté Vergara-Ortega2Santa García-Cisneros3María Olamendi-Portugal4Miguel Ángel Sánchez-Alemán5Antonia Herrera-Ortiz6Center for Infectious Diseases Research, National Institute of Public Health, Cuernavaca 62100, MexicoCenter for Infectious Diseases Research, National Institute of Public Health, Cuernavaca 62100, MexicoCenter for Infectious Diseases Research, National Institute of Public Health, Cuernavaca 62100, MexicoCenter for Infectious Diseases Research, National Institute of Public Health, Cuernavaca 62100, MexicoCenter for Infectious Diseases Research, National Institute of Public Health, Cuernavaca 62100, MexicoCenter for Infectious Diseases Research, National Institute of Public Health, Cuernavaca 62100, MexicoCenter for Infectious Diseases Research, National Institute of Public Health, Cuernavaca 62100, MexicoAdolescents and young people are particularly vulnerable to contracting STIs, including HSV-2; furthermore, vaginal shedding of HSV-2 during pregnancy can cause vertical transmission and neonatal herpes. To evaluate the seroprevalence of HSV-2 and vaginal HSV-2 shedding in adolescent and young pregnant women, a cross-sectional study was carried out in 496 pregnant women—adolescents and young women. Venous blood and vaginal exudate samples were taken. The seroprevalence of HSV-2 was determined by ELISA and Western blot. Vaginal HSV-2 shedding was assessed by qPCR of the HSV-2 UL30 gene. The seroprevalence of HSV-2 in the study population was 8.5% (95% CI 6–11), of which 38.1% had vaginal HSV-2 shedding (95% CI 22–53). Young women presented a higher seroprevalence of HSV-2 (12.1%) than adolescents (4.3%), OR = 3.4, 95% CI 1.59–7.23. Frequent alcohol consumption was significantly associated with HSV-2 seroprevalence, OR = 2.9, 95% CI 1.27–6.99. Vaginal HSV-2 shedding is highest in the third trimester of pregnancy, but this difference is not significant. The seroprevalence of HSV-2 in adolescents and young women is similar to that previously reported in other studies. However, the proportion of women with vaginal shedding of HSV-2 is higher during the third trimester of pregnancy, increasing the risk of vertical transmission.https://www.mdpi.com/1999-4915/15/5/1122HSV-2vaginal sheddingadolescent pregnancyseroprevalence |
| spellingShingle | Julio Cesar Muñiz-Salgado Gabriela Juárez-De la Cruz Dayana Nicté Vergara-Ortega Santa García-Cisneros María Olamendi-Portugal Miguel Ángel Sánchez-Alemán Antonia Herrera-Ortiz Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, Mexico Viruses HSV-2 vaginal shedding adolescent pregnancy seroprevalence |
| title | Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, Mexico |
| title_full | Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, Mexico |
| title_fullStr | Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, Mexico |
| title_full_unstemmed | Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, Mexico |
| title_short | Seroprevalence and Vaginal Shedding of Herpes Simplex Virus Type 2 in Pregnant Adolescents and Young Women from Morelos, Mexico |
| title_sort | seroprevalence and vaginal shedding of herpes simplex virus type 2 in pregnant adolescents and young women from morelos mexico |
| topic | HSV-2 vaginal shedding adolescent pregnancy seroprevalence |
| url | https://www.mdpi.com/1999-4915/15/5/1122 |
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