"PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION "
Interleukin-10 (IL-10) is a potent immunosuppressor which inhibits alloantigenic T cell response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive significance of endogenous IL-10 for acute graft versus host disease (GVHD) following allogeneic bone marrow transpl...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2005-06-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/2988 |
| _version_ | 1811324409490702336 |
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| author | M. Iravani B. Mohebbi B. Bahar K. Alimoghadam A. Moosavi S. Najar-Najafi A. Ardalan A. Ghavamzadeh |
| author_facet | M. Iravani B. Mohebbi B. Bahar K. Alimoghadam A. Moosavi S. Najar-Najafi A. Ardalan A. Ghavamzadeh |
| author_sort | M. Iravani |
| collection | DOAJ |
| description | Interleukin-10 (IL-10) is a potent immunosuppressor which inhibits alloantigenic T cell response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive significance of endogenous IL-10 for acute graft versus host disease (GVHD) following allogeneic bone marrow transplantation (BMT), we performed a prospective study on spontaneous IL-10 production in the serum of 96 patients admitted for allogeneic BMT. High spontaneous IL-10 production at the time of admission and prior to any preparative treatment correlates with a subsequent low incidence of GVHD as compared to patients with low IL-10 production. Our data demonstrate the predictive significance of increased IL-10 production in BMT patients and suggest a role for it in maintaining immunobalance in the setting of allogenic BMT. |
| first_indexed | 2024-04-13T14:13:48Z |
| format | Article |
| id | doaj.art-fa4942b3c7b54057a57097097e3e9b97 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-04-13T14:13:48Z |
| publishDate | 2005-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-fa4942b3c7b54057a57097097e3e9b972022-12-22T02:43:43ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942005-06-01433"PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION " M. Iravani0 B. Mohebbi1 B. Bahar2 K. Alimoghadam3 A. Moosavi4 S. Najar-Najafi5 A. Ardalan A. Ghavamzadeh6 Interleukin-10 (IL-10) is a potent immunosuppressor which inhibits alloantigenic T cell response. IL-10 is also an anti-inflammatory endogenous cytokine. To investigate the predictive significance of endogenous IL-10 for acute graft versus host disease (GVHD) following allogeneic bone marrow transplantation (BMT), we performed a prospective study on spontaneous IL-10 production in the serum of 96 patients admitted for allogeneic BMT. High spontaneous IL-10 production at the time of admission and prior to any preparative treatment correlates with a subsequent low incidence of GVHD as compared to patients with low IL-10 production. Our data demonstrate the predictive significance of increased IL-10 production in BMT patients and suggest a role for it in maintaining immunobalance in the setting of allogenic BMT.https://acta.tums.ac.ir/index.php/acta/article/view/2988interleukin-10graft versus host disease |
| spellingShingle | M. Iravani B. Mohebbi B. Bahar K. Alimoghadam A. Moosavi S. Najar-Najafi A. Ardalan A. Ghavamzadeh "PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION " Acta Medica Iranica interleukin-10 graft versus host disease |
| title | "PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION " |
| title_full | "PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION " |
| title_fullStr | "PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION " |
| title_full_unstemmed | "PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION " |
| title_short | "PREDICTIVE SIGNIFICANCE OF SERUM INTERLEUKIN-10 FOR ACUTE GRAFT VERSUS HOST DISEASE PRIOR TO ALLOGENEIC BONE MARROW TRASPLANTATION " |
| title_sort | predictive significance of serum interleukin 10 for acute graft versus host disease prior to allogeneic bone marrow trasplantation |
| topic | interleukin-10 graft versus host disease |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/2988 |
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