Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease
Abstract Background Reticulocyte indices have been suggested as alternatives to transferrin saturation (TSAT) for iron status assessment in humans and dogs but they have not been evaluated thoroughly in cats. Objectives To assess the value of the reticulocyte indices for the diagnosis of iron defici...
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.16367 |
| _version_ | 1818287003879342080 |
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| author | Adeline Betting Ariane Schweighauser Thierry Francey |
| author_facet | Adeline Betting Ariane Schweighauser Thierry Francey |
| author_sort | Adeline Betting |
| collection | DOAJ |
| description | Abstract Background Reticulocyte indices have been suggested as alternatives to transferrin saturation (TSAT) for iron status assessment in humans and dogs but they have not been evaluated thoroughly in cats. Objectives To assess the value of the reticulocyte indices for the diagnosis of iron deficiency in cats with chronic kidney disease (CKD) and chronic hematuria associated with subcutaneous ureteral bypasses (SUBs). Animals Sixty‐four cats: 16 healthy, 14 CKD without SUB, and 34 CKD with SUB. Methods Prospective observational cross‐sectional study of cats presented for routine nephrology visits. Primary outcomes included assessment of the diagnostic values of erythrocyte indices (mean corpuscular volume, hemoglobin, and hemoglobin concentration: MCV, MCH, and MCHC) and reticulocyte indices (mean corpuscular volume, MCVr; corpuscular hemoglobin, CHr), using TSAT as reference. Results Iron deficiency was diagnosed in 9/64 cats (14%). A receiver‐operating characteristic curve analysis yielded a moderate discriminatory value for CHr in this diagnosis: area under the curve [AUC] = .75 (95% confidence interval, 0.48‐0.89); P = .006; sensitivity 67%, specificity 82% for a cutoff of 15.9 pg. This compared favorably to MCVr (AUC = .63; P = .29), MCV (AUC = .58; P = .45), MCH (AUC = .64; P = .19), and MCHC (AUC = .7; P = .03). Conclusion and Clinical Importance CHr added moderate value to the diagnosis of iron deficiency in cats with CKD. |
| first_indexed | 2024-12-13T01:33:35Z |
| format | Article |
| id | doaj.art-fa4bced2b6a249efba44f459b04b4e62 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-13T01:33:35Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-fa4bced2b6a249efba44f459b04b4e622022-12-22T00:03:57ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762022-03-0136261962810.1111/jvim.16367Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney diseaseAdeline Betting0Ariane Schweighauser1Thierry Francey2Division of Small Animal Internal Medicine, Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern Bern SwitzerlandDivision of Small Animal Internal Medicine, Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern Bern SwitzerlandDivision of Small Animal Internal Medicine, Department of Clinical Veterinary Medicine Vetsuisse Faculty University of Bern Bern SwitzerlandAbstract Background Reticulocyte indices have been suggested as alternatives to transferrin saturation (TSAT) for iron status assessment in humans and dogs but they have not been evaluated thoroughly in cats. Objectives To assess the value of the reticulocyte indices for the diagnosis of iron deficiency in cats with chronic kidney disease (CKD) and chronic hematuria associated with subcutaneous ureteral bypasses (SUBs). Animals Sixty‐four cats: 16 healthy, 14 CKD without SUB, and 34 CKD with SUB. Methods Prospective observational cross‐sectional study of cats presented for routine nephrology visits. Primary outcomes included assessment of the diagnostic values of erythrocyte indices (mean corpuscular volume, hemoglobin, and hemoglobin concentration: MCV, MCH, and MCHC) and reticulocyte indices (mean corpuscular volume, MCVr; corpuscular hemoglobin, CHr), using TSAT as reference. Results Iron deficiency was diagnosed in 9/64 cats (14%). A receiver‐operating characteristic curve analysis yielded a moderate discriminatory value for CHr in this diagnosis: area under the curve [AUC] = .75 (95% confidence interval, 0.48‐0.89); P = .006; sensitivity 67%, specificity 82% for a cutoff of 15.9 pg. This compared favorably to MCVr (AUC = .63; P = .29), MCV (AUC = .58; P = .45), MCH (AUC = .64; P = .19), and MCHC (AUC = .7; P = .03). Conclusion and Clinical Importance CHr added moderate value to the diagnosis of iron deficiency in cats with CKD.https://doi.org/10.1111/jvim.16367CHriron deficiencyMCVrserum iron concentrationtransferrin saturation |
| spellingShingle | Adeline Betting Ariane Schweighauser Thierry Francey Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease Journal of Veterinary Internal Medicine CHr iron deficiency MCVr serum iron concentration transferrin saturation |
| title | Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease |
| title_full | Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease |
| title_fullStr | Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease |
| title_full_unstemmed | Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease |
| title_short | Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease |
| title_sort | diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease |
| topic | CHr iron deficiency MCVr serum iron concentration transferrin saturation |
| url | https://doi.org/10.1111/jvim.16367 |
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