COURAGE study results: disappointing or encouraging?
Based on СОURAGE study results (Clinical Outcomes Utilizing Percutaneous Coronary Revascularization and Aggressive Guideline-Driven Drug Evaluation), modern tactics for management of patients with coronary heart disease (CHD) and stable angina are discussed (percutaneous coronary intervention, PCI,...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
1970-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1502 |
| _version_ | 1797882848438386688 |
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| author | D. M. Aronov V. P. Lupanov |
| author_facet | D. M. Aronov V. P. Lupanov |
| author_sort | D. M. Aronov |
| collection | DOAJ |
| description | Based on СОURAGE study results (Clinical Outcomes Utilizing Percutaneous Coronary Revascularization and Aggressive Guideline-Driven Drug Evaluation), modern tactics for management of patients with coronary heart disease (CHD) and stable angina are discussed (percutaneous coronary intervention, PCI, or aggressive drug therapy with statins, aspirin, ACE inhibitors etc.). The role of secondary drug prevention, according to modern guidelines, is highly appraised. The emphasis is put on the leading role of lipid-lowering therapy with statins and ezetimibe. No significant difference was observed for complication rates in PCI group (n=1149) and optimal drug therapy (n=1138). Cumulative incidence of primary events during 4,6 years of follow-up was 19,0% and 18,5% in PCI and drug therapy groups, respectively (р=0,62). Therefore, in patients with stable CHD, PCI as a first-line strategy does not reduce the risk of death, myocardial infarction, or cardiovascular events, if combined with drug treatment. |
| first_indexed | 2024-04-10T03:42:13Z |
| format | Article |
| id | doaj.art-fa4befed89344ae2b4469e34957791f7 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:42:13Z |
| publishDate | 1970-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-fa4befed89344ae2b4469e34957791f72023-03-13T07:23:09Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01251970-01-0177951041220COURAGE study results: disappointing or encouraging?D. M. Aronov0V. P. Lupanov1ФГУ Государственный научно-исследовательский центр профилактической медицины РосмедтехнологииИнститут клинической кардиологии им. А.Л. Мясникова ФГУ РКНПК Росмедтехнологии, МоскваBased on СОURAGE study results (Clinical Outcomes Utilizing Percutaneous Coronary Revascularization and Aggressive Guideline-Driven Drug Evaluation), modern tactics for management of patients with coronary heart disease (CHD) and stable angina are discussed (percutaneous coronary intervention, PCI, or aggressive drug therapy with statins, aspirin, ACE inhibitors etc.). The role of secondary drug prevention, according to modern guidelines, is highly appraised. The emphasis is put on the leading role of lipid-lowering therapy with statins and ezetimibe. No significant difference was observed for complication rates in PCI group (n=1149) and optimal drug therapy (n=1138). Cumulative incidence of primary events during 4,6 years of follow-up was 19,0% and 18,5% in PCI and drug therapy groups, respectively (р=0,62). Therefore, in patients with stable CHD, PCI as a first-line strategy does not reduce the risk of death, myocardial infarction, or cardiovascular events, if combined with drug treatment.https://cardiovascular.elpub.ru/jour/article/view/1502ишемическая болезнь сердцалечениечрескожные интервенционные вмешательствастатиныэзетимиб |
| spellingShingle | D. M. Aronov V. P. Lupanov COURAGE study results: disappointing or encouraging? Кардиоваскулярная терапия и профилактика ишемическая болезнь сердца лечение чрескожные интервенционные вмешательства статины эзетимиб |
| title | COURAGE study results: disappointing or encouraging? |
| title_full | COURAGE study results: disappointing or encouraging? |
| title_fullStr | COURAGE study results: disappointing or encouraging? |
| title_full_unstemmed | COURAGE study results: disappointing or encouraging? |
| title_short | COURAGE study results: disappointing or encouraging? |
| title_sort | courage study results disappointing or encouraging |
| topic | ишемическая болезнь сердца лечение чрескожные интервенционные вмешательства статины эзетимиб |
| url | https://cardiovascular.elpub.ru/jour/article/view/1502 |
| work_keys_str_mv | AT dmaronov couragestudyresultsdisappointingorencouraging AT vplupanov couragestudyresultsdisappointingorencouraging |