Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition
Abstract The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. The organization of somatosensory endings is essential to their functions, yet the mechanisms which regulate this organization remain unclear...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Neural Development |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13064-023-00170-2 |
| _version_ | 1797836388982325248 |
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| author | Matthew B. Pomaville Kevin M. Wright |
| author_facet | Matthew B. Pomaville Kevin M. Wright |
| author_sort | Matthew B. Pomaville |
| collection | DOAJ |
| description | Abstract The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. The organization of somatosensory endings is essential to their functions, yet the mechanisms which regulate this organization remain unclear. Using a combination of genetic and molecular labeling approaches, we examined the development of mouse hair follicle-innervating low-threshold mechanoreceptors (LTMRs) and explored competition for innervation targets as a mechanism involved in the patterning of their receptive fields. We show that follicle innervating neurons are present in the skin at birth and that LTMR receptive fields gradually add follicle-innervating endings during the first two postnatal weeks. Using a constitutive Bax knockout to increase the number of neurons in adult animals, we show that two LTMR subtypes have differential responses to an increase in neuronal population size: Aδ-LTMR neurons shrink their receptive fields to accommodate the increased number of neurons innervating the skin, while C-LTMR neurons do not. Our findings suggest that competition for hair follicles to innervate plays a role in the patterning and organization of follicle-innervating LTMR neurons. |
| first_indexed | 2024-04-09T15:08:03Z |
| format | Article |
| id | doaj.art-fa4c71b9b8a24a4e82fc20c74bc9ee7e |
| institution | Directory Open Access Journal |
| issn | 1749-8104 |
| language | English |
| last_indexed | 2024-04-09T15:08:03Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Neural Development |
| spelling | doaj.art-fa4c71b9b8a24a4e82fc20c74bc9ee7e2023-04-30T11:23:52ZengBMCNeural Development1749-81042023-04-0118111810.1186/s13064-023-00170-2Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competitionMatthew B. Pomaville0Kevin M. Wright1Vollum Institute, Oregon Health and Science UniversityVollum Institute, Oregon Health and Science UniversityAbstract The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. The organization of somatosensory endings is essential to their functions, yet the mechanisms which regulate this organization remain unclear. Using a combination of genetic and molecular labeling approaches, we examined the development of mouse hair follicle-innervating low-threshold mechanoreceptors (LTMRs) and explored competition for innervation targets as a mechanism involved in the patterning of their receptive fields. We show that follicle innervating neurons are present in the skin at birth and that LTMR receptive fields gradually add follicle-innervating endings during the first two postnatal weeks. Using a constitutive Bax knockout to increase the number of neurons in adult animals, we show that two LTMR subtypes have differential responses to an increase in neuronal population size: Aδ-LTMR neurons shrink their receptive fields to accommodate the increased number of neurons innervating the skin, while C-LTMR neurons do not. Our findings suggest that competition for hair follicles to innervate plays a role in the patterning and organization of follicle-innervating LTMR neurons.https://doi.org/10.1186/s13064-023-00170-2LTMRSomatosensory neuronTilingBaxHair follicle |
| spellingShingle | Matthew B. Pomaville Kevin M. Wright Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition Neural Development LTMR Somatosensory neuron Tiling Bax Hair follicle |
| title | Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition |
| title_full | Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition |
| title_fullStr | Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition |
| title_full_unstemmed | Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition |
| title_short | Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition |
| title_sort | follicle innervating aδ low threshold mechanoreceptive neurons form receptive fields through homotypic competition |
| topic | LTMR Somatosensory neuron Tiling Bax Hair follicle |
| url | https://doi.org/10.1186/s13064-023-00170-2 |
| work_keys_str_mv | AT matthewbpomaville follicleinnervatingadlowthresholdmechanoreceptiveneuronsformreceptivefieldsthroughhomotypiccompetition AT kevinmwright follicleinnervatingadlowthresholdmechanoreceptiveneuronsformreceptivefieldsthroughhomotypiccompetition |