EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMA
Purpose: Overexpression of antiapoptotic B-cell lymphoma-2 (Bcl-2) protein is one of the major contributors to oncogenesis and high levels have been identified in a variety of tumour types. We investigated an immunohistochemical expression of Bcl-2 protein in cutaneous basal cell carcinomas (BCCs) t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Shaukat Khanum Memorial Trust
2018-12-01
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| Series: | Journal of Cancer and Allied Specialties |
| Online Access: | http://journals.sfu.ca/jcas/index.php/jcas/article/view/202 |
| _version_ | 1818390770027069440 |
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| author | Vladimír Bartoš Millada Kullová |
| author_facet | Vladimír Bartoš Millada Kullová |
| author_sort | Vladimír Bartoš |
| collection | DOAJ |
| description | Purpose: Overexpression of antiapoptotic B-cell lymphoma-2 (Bcl-2) protein is one of the major contributors to oncogenesis and high levels have been identified in a variety of tumour types. We investigated an immunohistochemical
expression of Bcl-2 protein in cutaneous basal cell carcinomas (BCCs) to elucidate whether there are differences in the expression pattern related to tumour growth phenotype.
Materials and Methods: The study group consisted of 45 cutaneous BCCs, which were categorised into the nonaggressive (NA-BCCs; 31 cases) and aggressive histologic variants (A-BCCs; 14 cases).
Results: There were 3 tumours (6.6%) with negative staining and 42 tumours (93.4%) with positive staining for Bcl-2 protein, 10 of which (23.8%) displayed low and remaining 32 cases (76.2%) exhibited high expression. All three “Bcl-
2 negative” BCCs showed aggressive-growth features (infiltrative subtypes). When Bcl-2 values were evaluated as negative/low versus high expression, there was significantly lower Bcl-2 protein expression in the A-BCCs compared
to the NA-BCCs. Even an intensity of immunostaining showed a tendency of being weaker in the A-BCCs. In spite of that, three infiltrative BCCs showed a diffuse strong immunoreactivity.
Conclusion: An immunohistochemical positivity of Bcl-2 protein in the neoplastic cells of cutaneous BCC was nearly constant feature, and its decreased staining was associated with an infiltrative growth pattern. It suggests that a low
Bcl-2 protein expression in tumor tissue might be considered an unfavorable prognostic indicator.
Key words: Basal cell carcinoma, B-cell lymphoma-2 protein, biological behavior |
| first_indexed | 2024-12-14T05:02:54Z |
| format | Article |
| id | doaj.art-fa4db967706e428b844363ec46b34aaf |
| institution | Directory Open Access Journal |
| issn | 2411-989X |
| language | English |
| last_indexed | 2024-12-14T05:02:54Z |
| publishDate | 2018-12-01 |
| publisher | Shaukat Khanum Memorial Trust |
| record_format | Article |
| series | Journal of Cancer and Allied Specialties |
| spelling | doaj.art-fa4db967706e428b844363ec46b34aaf2022-12-21T23:16:11ZengShaukat Khanum Memorial TrustJournal of Cancer and Allied Specialties2411-989X2018-12-014410.37029/jcas.v4i4.202EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMAVladimír Bartoš0Millada Kullová1Department of Pathology, Faculty Hospital in Žilina, SlovakiaDepartment of Dermatovenerology, Faculty Hospital in Žilina, SlovakiaPurpose: Overexpression of antiapoptotic B-cell lymphoma-2 (Bcl-2) protein is one of the major contributors to oncogenesis and high levels have been identified in a variety of tumour types. We investigated an immunohistochemical expression of Bcl-2 protein in cutaneous basal cell carcinomas (BCCs) to elucidate whether there are differences in the expression pattern related to tumour growth phenotype. Materials and Methods: The study group consisted of 45 cutaneous BCCs, which were categorised into the nonaggressive (NA-BCCs; 31 cases) and aggressive histologic variants (A-BCCs; 14 cases). Results: There were 3 tumours (6.6%) with negative staining and 42 tumours (93.4%) with positive staining for Bcl-2 protein, 10 of which (23.8%) displayed low and remaining 32 cases (76.2%) exhibited high expression. All three “Bcl- 2 negative” BCCs showed aggressive-growth features (infiltrative subtypes). When Bcl-2 values were evaluated as negative/low versus high expression, there was significantly lower Bcl-2 protein expression in the A-BCCs compared to the NA-BCCs. Even an intensity of immunostaining showed a tendency of being weaker in the A-BCCs. In spite of that, three infiltrative BCCs showed a diffuse strong immunoreactivity. Conclusion: An immunohistochemical positivity of Bcl-2 protein in the neoplastic cells of cutaneous BCC was nearly constant feature, and its decreased staining was associated with an infiltrative growth pattern. It suggests that a low Bcl-2 protein expression in tumor tissue might be considered an unfavorable prognostic indicator. Key words: Basal cell carcinoma, B-cell lymphoma-2 protein, biological behaviorhttp://journals.sfu.ca/jcas/index.php/jcas/article/view/202 |
| spellingShingle | Vladimír Bartoš Millada Kullová EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMA Journal of Cancer and Allied Specialties |
| title | EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMA |
| title_full | EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMA |
| title_fullStr | EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMA |
| title_full_unstemmed | EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMA |
| title_short | EXPRESSION OF ANTI-APOPTOTIC PROTEIN BCL-2 IN CUTANEOUS BASAL CELL CARCINOMA |
| title_sort | expression of anti apoptotic protein bcl 2 in cutaneous basal cell carcinoma |
| url | http://journals.sfu.ca/jcas/index.php/jcas/article/view/202 |
| work_keys_str_mv | AT vladimirbartos expressionofantiapoptoticproteinbcl2incutaneousbasalcellcarcinoma AT milladakullova expressionofantiapoptoticproteinbcl2incutaneousbasalcellcarcinoma |