Early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation
Abstract Background Although epithelial ovarian cancer (EOC) spreads through peritoneal circulation, all patients with clinical early-stage ovarian cancer (OC) benefit from routine surgical staging is still unclear. Methods This cross-sectional study used data from medical records of patients with c...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-021-00795-z |
| _version_ | 1797967827363168256 |
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| author | Sigit Purbadi Tricia Dewi Anggraeni Angelina Vitria |
| author_facet | Sigit Purbadi Tricia Dewi Anggraeni Angelina Vitria |
| author_sort | Sigit Purbadi |
| collection | DOAJ |
| description | Abstract Background Although epithelial ovarian cancer (EOC) spreads through peritoneal circulation, all patients with clinical early-stage ovarian cancer (OC) benefit from routine surgical staging is still unclear. Methods This cross-sectional study used data from medical records of patients with clinical early-stage EOC who received complete surgical staging from 2006 to 2016 at our hospital. We excluded patients with non-epithelial OC or with stage IV disease. Results Among 50 patients with clinical early-stage EOC who underwent surgical staging, biopsies showed EOC cells in peritoneal fluid for 12 patients (24%), in peritoneal tissue for ten patients (20%), and omental tissue for eight patients (16%). Of those 50 patients, 40 patients had undergone peritoneal biopsies, and the other five patients also had omental biopsies. The results showed that only one (2.5%) from 40 patients with peritoneal biopsy and three (6.7%) from 45 patients with omental biopsy had no visible nodules. From cytology examination, 3 out of 26 patients (11.5%) showed positive cytology from peritoneal washing. Conclusions Routine peritoneal biopsies do not seem advantageous for patients with clinical early-stage EOC as negative visible nodules with positive biopsy results were only 1 in 40 cases. However, further study with a larger cohort is needed to obtain more information on peritoneal fluid metastasis patterns. |
| first_indexed | 2024-04-11T02:37:19Z |
| format | Article |
| id | doaj.art-fa511b4f497d4f6798cdc7cbe966d0a7 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:37:19Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-fa511b4f497d4f6798cdc7cbe966d0a72023-01-02T20:05:24ZengBMCJournal of Ovarian Research1757-22152021-03-011411510.1186/s13048-021-00795-zEarly stage epithelial ovarian cancer metastasis through peritoneal fluid circulationSigit Purbadi0Tricia Dewi Anggraeni1Angelina Vitria2Division of Gynecologic Oncology. Department of Obstetrics and Gynecology, Cipto Mangunkusumo HospitalDivision of Gynecologic Oncology. Department of Obstetrics and Gynecology, Cipto Mangunkusumo HospitalDivision of Gynecologic Oncology. Department of Obstetrics and Gynecology, Cipto Mangunkusumo HospitalAbstract Background Although epithelial ovarian cancer (EOC) spreads through peritoneal circulation, all patients with clinical early-stage ovarian cancer (OC) benefit from routine surgical staging is still unclear. Methods This cross-sectional study used data from medical records of patients with clinical early-stage EOC who received complete surgical staging from 2006 to 2016 at our hospital. We excluded patients with non-epithelial OC or with stage IV disease. Results Among 50 patients with clinical early-stage EOC who underwent surgical staging, biopsies showed EOC cells in peritoneal fluid for 12 patients (24%), in peritoneal tissue for ten patients (20%), and omental tissue for eight patients (16%). Of those 50 patients, 40 patients had undergone peritoneal biopsies, and the other five patients also had omental biopsies. The results showed that only one (2.5%) from 40 patients with peritoneal biopsy and three (6.7%) from 45 patients with omental biopsy had no visible nodules. From cytology examination, 3 out of 26 patients (11.5%) showed positive cytology from peritoneal washing. Conclusions Routine peritoneal biopsies do not seem advantageous for patients with clinical early-stage EOC as negative visible nodules with positive biopsy results were only 1 in 40 cases. However, further study with a larger cohort is needed to obtain more information on peritoneal fluid metastasis patterns.https://doi.org/10.1186/s13048-021-00795-zEpithelial ovarian cancerProportion of spreadingSurgical staging |
| spellingShingle | Sigit Purbadi Tricia Dewi Anggraeni Angelina Vitria Early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation Journal of Ovarian Research Epithelial ovarian cancer Proportion of spreading Surgical staging |
| title | Early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation |
| title_full | Early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation |
| title_fullStr | Early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation |
| title_full_unstemmed | Early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation |
| title_short | Early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation |
| title_sort | early stage epithelial ovarian cancer metastasis through peritoneal fluid circulation |
| topic | Epithelial ovarian cancer Proportion of spreading Surgical staging |
| url | https://doi.org/10.1186/s13048-021-00795-z |
| work_keys_str_mv | AT sigitpurbadi earlystageepithelialovariancancermetastasisthroughperitonealfluidcirculation AT triciadewianggraeni earlystageepithelialovariancancermetastasisthroughperitonealfluidcirculation AT angelinavitria earlystageepithelialovariancancermetastasisthroughperitonealfluidcirculation |