In Silico Reconstruction of Sperm Chemotaxis
In echinoderms, sperm swims in random circles and turns in response to a chemoattractant. The chemoattractant evokes transient Ca<sup>2+</sup> influx in the sperm flagellum and induces turning behavior. Recently, the molecular mechanisms and biophysical properties of this sperm response...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/17/9104 |
| _version_ | 1797521414815744000 |
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| author | Masahiro Naruse Midori Matsumoto |
| author_facet | Masahiro Naruse Midori Matsumoto |
| author_sort | Masahiro Naruse |
| collection | DOAJ |
| description | In echinoderms, sperm swims in random circles and turns in response to a chemoattractant. The chemoattractant evokes transient Ca<sup>2+</sup> influx in the sperm flagellum and induces turning behavior. Recently, the molecular mechanisms and biophysical properties of this sperm response have been clarified. Based on these experimental findings, in this study, we reconstructed a sperm model in silico to demonstrate an algorithm for sperm chemotaxis. We also focused on the importance of desensitizing the chemoattractant receptor in long-range chemotaxis because sperm approach distantly located eggs, and they must sense the chemoattractant concentration over a broad range. Using parameters of the sea urchin, simulations showed that a number of sperm could reach the egg from millimeter-order distances with desensitization, indicating that we could organize a functional sperm model, and that desensitization of the receptor is essential for sperm chemotaxis. Then, we compared the model with starfish sperm, which has a different desensitization scheme and analyzed the properties of the model against various disturbances. Our approach can be applied as a novel tool in chemotaxis research. |
| first_indexed | 2024-03-10T08:12:16Z |
| format | Article |
| id | doaj.art-fa538c84fcb24d17b3f4a1eaf15bfa82 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:12:16Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fa538c84fcb24d17b3f4a1eaf15bfa822023-11-22T10:38:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012217910410.3390/ijms22179104In Silico Reconstruction of Sperm ChemotaxisMasahiro Naruse0Midori Matsumoto1Department of Bioscience and Informatics, Keio University, Yokohama 223-8522, JapanDepartment of Bioscience and Informatics, Keio University, Yokohama 223-8522, JapanIn echinoderms, sperm swims in random circles and turns in response to a chemoattractant. The chemoattractant evokes transient Ca<sup>2+</sup> influx in the sperm flagellum and induces turning behavior. Recently, the molecular mechanisms and biophysical properties of this sperm response have been clarified. Based on these experimental findings, in this study, we reconstructed a sperm model in silico to demonstrate an algorithm for sperm chemotaxis. We also focused on the importance of desensitizing the chemoattractant receptor in long-range chemotaxis because sperm approach distantly located eggs, and they must sense the chemoattractant concentration over a broad range. Using parameters of the sea urchin, simulations showed that a number of sperm could reach the egg from millimeter-order distances with desensitization, indicating that we could organize a functional sperm model, and that desensitization of the receptor is essential for sperm chemotaxis. Then, we compared the model with starfish sperm, which has a different desensitization scheme and analyzed the properties of the model against various disturbances. Our approach can be applied as a novel tool in chemotaxis research.https://www.mdpi.com/1422-0067/22/17/9104fertilizationsperm chemotaxismodeling of celldesensitization |
| spellingShingle | Masahiro Naruse Midori Matsumoto In Silico Reconstruction of Sperm Chemotaxis International Journal of Molecular Sciences fertilization sperm chemotaxis modeling of cell desensitization |
| title | In Silico Reconstruction of Sperm Chemotaxis |
| title_full | In Silico Reconstruction of Sperm Chemotaxis |
| title_fullStr | In Silico Reconstruction of Sperm Chemotaxis |
| title_full_unstemmed | In Silico Reconstruction of Sperm Chemotaxis |
| title_short | In Silico Reconstruction of Sperm Chemotaxis |
| title_sort | in silico reconstruction of sperm chemotaxis |
| topic | fertilization sperm chemotaxis modeling of cell desensitization |
| url | https://www.mdpi.com/1422-0067/22/17/9104 |
| work_keys_str_mv | AT masahironaruse insilicoreconstructionofspermchemotaxis AT midorimatsumoto insilicoreconstructionofspermchemotaxis |