Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies
Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on children. Current therapies for AD are challenged by the limited armamentarium and the high heterogeneity of the disease. A novel promising therapeutic target for AD is the microbiota. Numerous studies have...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/6/642 |
| _version_ | 1797483572536279040 |
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| author | Md Jahangir Alam Liang Xie Yu-Anne Yap Francine Z. Marques Remy Robert |
| author_facet | Md Jahangir Alam Liang Xie Yu-Anne Yap Francine Z. Marques Remy Robert |
| author_sort | Md Jahangir Alam |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on children. Current therapies for AD are challenged by the limited armamentarium and the high heterogeneity of the disease. A novel promising therapeutic target for AD is the microbiota. Numerous studies have highlighted the involvement of the skin and gut microbiota in the pathogenesis of AD. The resident microbiota at these two epithelial tissues can modulate skin barrier functions and host immune responses, thus regulating AD progression. For example, the pathogenic roles of <i>Staphylococcus aureus</i> in the skin are well-established, making this bacterium an attractive target for AD treatment. Targeting the gut microbiota is another therapeutic strategy for AD. Multiple oral supplements with prebiotics, probiotics, postbiotics, and synbiotics have demonstrated promising efficacy in both AD prevention and treatment. In this review, we summarize the association of microbiota dysbiosis in both the skin and gut with AD, and the current knowledge of the functions of commensal microbiota in AD pathogenesis. Furthermore, we discuss the existing therapies in manipulating both the skin and gut commensal microbiota to prevent or treat AD. We also propose potential novel therapies based on the cutting-edge progress in this area. |
| first_indexed | 2024-03-09T22:48:57Z |
| format | Article |
| id | doaj.art-fa54b781528043f7b5e47ac7cba48d90 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T22:48:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-fa54b781528043f7b5e47ac7cba48d902023-11-23T18:24:33ZengMDPI AGPathogens2076-08172022-06-0111664210.3390/pathogens11060642Manipulating Microbiota to Treat Atopic Dermatitis: Functions and TherapiesMd Jahangir Alam0Liang Xie1Yu-Anne Yap2Francine Z. Marques3Remy Robert4Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaDepartment of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaHypertension Research Laboratory, School of Biological Sciences, Monash University, Clayton, VIC 3800, AustraliaDepartment of Physiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaAtopic dermatitis (AD) is a globally prevalent skin inflammation with a particular impact on children. Current therapies for AD are challenged by the limited armamentarium and the high heterogeneity of the disease. A novel promising therapeutic target for AD is the microbiota. Numerous studies have highlighted the involvement of the skin and gut microbiota in the pathogenesis of AD. The resident microbiota at these two epithelial tissues can modulate skin barrier functions and host immune responses, thus regulating AD progression. For example, the pathogenic roles of <i>Staphylococcus aureus</i> in the skin are well-established, making this bacterium an attractive target for AD treatment. Targeting the gut microbiota is another therapeutic strategy for AD. Multiple oral supplements with prebiotics, probiotics, postbiotics, and synbiotics have demonstrated promising efficacy in both AD prevention and treatment. In this review, we summarize the association of microbiota dysbiosis in both the skin and gut with AD, and the current knowledge of the functions of commensal microbiota in AD pathogenesis. Furthermore, we discuss the existing therapies in manipulating both the skin and gut commensal microbiota to prevent or treat AD. We also propose potential novel therapies based on the cutting-edge progress in this area.https://www.mdpi.com/2076-0817/11/6/642atopic dermatitisskin microbiotagut microbiotametabolitesshort-chain fatty acidsG-protein-coupled receptors |
| spellingShingle | Md Jahangir Alam Liang Xie Yu-Anne Yap Francine Z. Marques Remy Robert Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies Pathogens atopic dermatitis skin microbiota gut microbiota metabolites short-chain fatty acids G-protein-coupled receptors |
| title | Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies |
| title_full | Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies |
| title_fullStr | Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies |
| title_full_unstemmed | Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies |
| title_short | Manipulating Microbiota to Treat Atopic Dermatitis: Functions and Therapies |
| title_sort | manipulating microbiota to treat atopic dermatitis functions and therapies |
| topic | atopic dermatitis skin microbiota gut microbiota metabolites short-chain fatty acids G-protein-coupled receptors |
| url | https://www.mdpi.com/2076-0817/11/6/642 |
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