Combating challenges in CAR-T cells with engineering immunology

Combating challenges in CAR-T cells with engineering immunology

Chimeric antigen receptors (CAR) T cells (CAR-T) mark a significant step towards producing safe and effective personal anticancer treatments. CAR-T strategies engineers the T cells from the patients to allow specific binding to a tumour-specific antigen. CAR-Ts are a second-wave offensive strategy t...

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Bibliographic Details
Main Authors: Clement Yisai Wang, Stephanie Po Ting Cheung, Ryohichi Sugimura
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
car-t
antigen
immune checkpoint inhibitors
cancer immune cell therapy
tumor micro environment
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.969020/full

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