Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia
Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the poten...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-08-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506119301254 |
| _version_ | 1818173075697434624 |
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| author | Xinyue Bai Xian-Jie Yang Ling Chen |
| author_facet | Xinyue Bai Xian-Jie Yang Ling Chen |
| author_sort | Xinyue Bai |
| collection | DOAJ |
| description | Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM. |
| first_indexed | 2024-12-11T19:22:45Z |
| format | Article |
| id | doaj.art-fa568ed77ed148e49ab859b2c6f55d17 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-11T19:22:45Z |
| publishDate | 2019-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-fa568ed77ed148e49ab859b2c6f55d172022-12-22T00:53:29ZengElsevierStem Cell Research1873-50612019-08-0139Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopiaXinyue Bai0Xian-Jie Yang1Ling Chen2Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, ChinaJules Stein Eye Institute, University of California Los Angeles, California, USADepartment of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Corresponding author at: Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China.Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their pluripotency and genetic stability, as well as the potential to differentiate to retinal pigment epithelium (RPE). This line may serve as a useful tool to explore the pathogenesis of PM.http://www.sciencedirect.com/science/article/pii/S1873506119301254 |
| spellingShingle | Xinyue Bai Xian-Jie Yang Ling Chen Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia Stem Cell Research |
| title | Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia |
| title_full | Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia |
| title_fullStr | Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia |
| title_full_unstemmed | Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia |
| title_short | Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia |
| title_sort | generation of an integration free induced pluripotent stem cell line fdeenti003 a from a patient with pathological myopia |
| url | http://www.sciencedirect.com/science/article/pii/S1873506119301254 |
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