A Reliable Enantioselective Route to Mono-Protected N1-Cbz Piperazic Acid Building Block

A Reliable Enantioselective Route to Mono-Protected N1-Cbz Piperazic Acid Building Block

The chiral N1-Cbz, N2-<i>H</i> derivative of the piperazic acid monomer is a valuable building block in the total synthesis of natural products, comprising this nonproteinogenic amino acid. In that context, we wish to report an improved synthetic protocol for the synthesis of both (3<...

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Bibliographic Details
Main Authors: Evanthia Papadaki, Dimitris Georgiadis, Michail Tsakos
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
natural products
piperazate
nonproteinogenic
amino acid
peptides
peptidomimetics
Online Access:https://www.mdpi.com/1420-3049/25/24/5939

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