Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinus
The population of catfish, Clarias batrachus has substantially diminished in various countries and studies show that another related species Clarias gariepinus is replacing it. The better adaptability and survivability of C. gariepinus over C. batrachus could be attributed to the metabolic differenc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-07-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580821000790 |
| _version_ | 1818930018803253248 |
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| author | Gyanendra Bahadur Chand Sushant Kumar Gajendra Kumar Azad |
| author_facet | Gyanendra Bahadur Chand Sushant Kumar Gajendra Kumar Azad |
| author_sort | Gyanendra Bahadur Chand |
| collection | DOAJ |
| description | The population of catfish, Clarias batrachus has substantially diminished in various countries and studies show that another related species Clarias gariepinus is replacing it. The better adaptability and survivability of C. gariepinus over C. batrachus could be attributed to the metabolic differences between these two species, which is primarily regulated by mitochondrial activities. To understand the reasons behind this phenomenon, we performed in silico analyses to decipher the differences between the proteins encoded by the mitochondrial genome of these two related species. Our analysis revealed that out of thirteen, twelve proteins encoded by the mitochondrial genome of these two species have substantial variations between them. We characterised these variations by analysing their effect on secondary structure, intrinsic disorder predisposition, and functional impact on protein and stability parameters. Our data show that most of the parameters are changing between these two closely related species. Altogether, we demonstrate the molecular insights into the mitochondrial genome-encoded proteins of these two species and predict their effect on protein function and stability that might be helping C. gariepinus to gain survivability better than the C. batrachus. |
| first_indexed | 2024-12-20T03:54:02Z |
| format | Article |
| id | doaj.art-fa5b73480546421d8440dd1066aca638 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-20T03:54:02Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-fa5b73480546421d8440dd1066aca6382022-12-21T19:54:23ZengElsevierBiochemistry and Biophysics Reports2405-58082021-07-0126100985Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinusGyanendra Bahadur Chand0Sushant Kumar1Gajendra Kumar Azad2Department of Zoology, Patna University, Patna, Bihar, 800005, IndiaDepartment of Zoology, Patna University, Patna, Bihar, 800005, IndiaCorresponding author.; Department of Zoology, Patna University, Patna, Bihar, 800005, IndiaThe population of catfish, Clarias batrachus has substantially diminished in various countries and studies show that another related species Clarias gariepinus is replacing it. The better adaptability and survivability of C. gariepinus over C. batrachus could be attributed to the metabolic differences between these two species, which is primarily regulated by mitochondrial activities. To understand the reasons behind this phenomenon, we performed in silico analyses to decipher the differences between the proteins encoded by the mitochondrial genome of these two related species. Our analysis revealed that out of thirteen, twelve proteins encoded by the mitochondrial genome of these two species have substantial variations between them. We characterised these variations by analysing their effect on secondary structure, intrinsic disorder predisposition, and functional impact on protein and stability parameters. Our data show that most of the parameters are changing between these two closely related species. Altogether, we demonstrate the molecular insights into the mitochondrial genome-encoded proteins of these two species and predict their effect on protein function and stability that might be helping C. gariepinus to gain survivability better than the C. batrachus.http://www.sciencedirect.com/science/article/pii/S2405580821000790Clarias batrachusClarias gariepinusMitochondrial genomeVariationsProtein stability |
| spellingShingle | Gyanendra Bahadur Chand Sushant Kumar Gajendra Kumar Azad Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinus Biochemistry and Biophysics Reports Clarias batrachus Clarias gariepinus Mitochondrial genome Variations Protein stability |
| title | Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinus |
| title_full | Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinus |
| title_fullStr | Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinus |
| title_full_unstemmed | Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinus |
| title_short | Molecular assessment of proteins encoded by the mitochondrial genome of Clarias batrachus and Clarias gariepinus |
| title_sort | molecular assessment of proteins encoded by the mitochondrial genome of clarias batrachus and clarias gariepinus |
| topic | Clarias batrachus Clarias gariepinus Mitochondrial genome Variations Protein stability |
| url | http://www.sciencedirect.com/science/article/pii/S2405580821000790 |
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