A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5
ABSTRACTThe SARS-CoV-2 Omicron variants of concern (VOCs) showed severe resistance to the early-approved COVID-19 vaccines-induced immune responses. The breakthrough infections by the Omicron VOCs are currently the major challenge for pandemic control. Therefore, booster vaccination is crucial to en...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2179357 |
| _version_ | 1797652840465825792 |
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| author | Minrun Duan Huixin Duan Yaling An Tianyi Zheng Shengfeng Wan Hui Wang Xin Zhao Lianpan Dai Kun Xu George F. Gao |
| author_facet | Minrun Duan Huixin Duan Yaling An Tianyi Zheng Shengfeng Wan Hui Wang Xin Zhao Lianpan Dai Kun Xu George F. Gao |
| author_sort | Minrun Duan |
| collection | DOAJ |
| description | ABSTRACTThe SARS-CoV-2 Omicron variants of concern (VOCs) showed severe resistance to the early-approved COVID-19 vaccines-induced immune responses. The breakthrough infections by the Omicron VOCs are currently the major challenge for pandemic control. Therefore, booster vaccination is crucial to enhance immune responses and protective efficacy. Previously, we developed a protein subunit COVID-19 vaccine ZF2001, based on the immunogen of receptor-binding domain (RBD) homodimer, which was approved in China and other countries. To adapt SARS-CoV-2 variants, we further developed chimeric Delta-Omicron BA.1 RBD-dimer immunogen which induced broad immune responses against SARS-CoV-2 variants. In this study, we tested the boosting effect of this chimeric RBD-dimer vaccine in mice after priming with two doses of inactivated vaccines, compared with a booster of inactivated vaccine or ZF2001. The results demonstrated that boosting with bivalent Delta-Omicron BA.1 vaccine greatly promoted the neutralizing activity of the sera to all tested SARS-CoV-2 variants. Therefore, the Delta-Omicron chimeric RBD-dimer vaccine is a feasible booster for those with prior vaccination of COVID-19 inactivated vaccines. |
| first_indexed | 2024-03-11T16:35:43Z |
| format | Article |
| id | doaj.art-fa5c1d44500d49c59232eee942576d36 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-11T16:35:43Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-fa5c1d44500d49c59232eee942576d362023-10-23T17:36:55ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2023.2179357A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5Minrun Duan0Huixin Duan1Yaling An2Tianyi Zheng3Shengfeng Wan4Hui Wang5Xin Zhao6Lianpan Dai7Kun Xu8George F. Gao9School of Life Sciences, Yunnan University, Kunming, People’s Republic of ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, People’s Republic of ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, People’s Republic of ChinaZhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaBeijing Institute of Biological Products Company Limited, Beijing, People’s Republic of ChinaCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, People’s Republic of ChinaResearch Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, People’s Republic of ChinaABSTRACTThe SARS-CoV-2 Omicron variants of concern (VOCs) showed severe resistance to the early-approved COVID-19 vaccines-induced immune responses. The breakthrough infections by the Omicron VOCs are currently the major challenge for pandemic control. Therefore, booster vaccination is crucial to enhance immune responses and protective efficacy. Previously, we developed a protein subunit COVID-19 vaccine ZF2001, based on the immunogen of receptor-binding domain (RBD) homodimer, which was approved in China and other countries. To adapt SARS-CoV-2 variants, we further developed chimeric Delta-Omicron BA.1 RBD-dimer immunogen which induced broad immune responses against SARS-CoV-2 variants. In this study, we tested the boosting effect of this chimeric RBD-dimer vaccine in mice after priming with two doses of inactivated vaccines, compared with a booster of inactivated vaccine or ZF2001. The results demonstrated that boosting with bivalent Delta-Omicron BA.1 vaccine greatly promoted the neutralizing activity of the sera to all tested SARS-CoV-2 variants. Therefore, the Delta-Omicron chimeric RBD-dimer vaccine is a feasible booster for those with prior vaccination of COVID-19 inactivated vaccines.https://www.tandfonline.com/doi/10.1080/22221751.2023.2179357SARS-CoV-2OmicronZF2001RBD-dimervaccine |
| spellingShingle | Minrun Duan Huixin Duan Yaling An Tianyi Zheng Shengfeng Wan Hui Wang Xin Zhao Lianpan Dai Kun Xu George F. Gao A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5 Emerging Microbes and Infections SARS-CoV-2 Omicron ZF2001 RBD-dimer vaccine |
| title | A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5 |
| title_full | A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5 |
| title_fullStr | A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5 |
| title_full_unstemmed | A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5 |
| title_short | A booster of Delta-Omicron RBD-dimer protein subunit vaccine augments sera neutralization of Omicron sub-variants BA.1/BA.2/BA.2.12.1/BA.4/BA.5 |
| title_sort | booster of delta omicron rbd dimer protein subunit vaccine augments sera neutralization of omicron sub variants ba 1 ba 2 ba 2 12 1 ba 4 ba 5 |
| topic | SARS-CoV-2 Omicron ZF2001 RBD-dimer vaccine |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2179357 |
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