Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons

Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons

<p>Abstract</p> <p>Background</p> <p>Prokineticin 2 (PK2) is a secreted protein and causes potent hyperalgesia in vivo, and is therefore considered to be a new pronociceptive mediator. However, the molecular targets responsible for the pronociceptive effects of PK2 are...

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Bibliographic Details
Main Authors: Qiu Chun-Yu, Liu Yu-Qiang, Qiu Fang, Wu Jiliang, Zhou Qun-Yong, Hu Wang-Ping
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Journal of Neuroinflammation
Subjects:
Acid-sensing ion channel
Dorsal root ganglion neuron
Neuronal excitability
Pain
Prokineticin 2
Proton-gated current
Online Access:http://www.jneuroinflammation.com/content/9/1/108

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