5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis
Abstract Background 5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely...
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| Format: | Article |
| Language: | English |
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BMC
2017-03-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12958-017-0242-9 |
| _version_ | 1818304337830477824 |
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| author | Chuyan Wu Ke Wei Zhongli Jiang |
| author_facet | Chuyan Wu Ke Wei Zhongli Jiang |
| author_sort | Chuyan Wu |
| collection | DOAJ |
| description | Abstract Background 5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely unknown. Methods We performed a meta-analysis to examine 5α-reductase activity in women with PCOS; exploratory subgroup analyses were also performed. Results Five articles (with 356 cases and 236 controls) reporting 5α-reductase activity in patients with PCOS were selected for the meta-analysis. We observed significantly higher ratios of 5αTHF/THF (5α-reduced tetrahydrocortisol to 5β-reduced tetrahydrocortisol) and An/Et (androsteroneto/etiocholanolone) levels, which were used to assess 5α-reductase activity, among the patients with PCOS, [standardized mean differences (SMD) =0.43, 95%confidence intervals (95%CI) =0.25–0.61, P < 0.00001; SMD = 0.86, 95% CI = 0.29–1.44, P = 0.003]. We observed significant heterogeneity between studies for An/Et (I2 = 89% and P < 0.00001). According to the group analysis, women with PCOS exhibited increased 5α-reductase activity which was significantly associated with homeostasis model assessment of insulin resistance (HOMA-IR) regardless of obesity. Conclusions 5α-reductase activity was enhanced in women with PCOS. Increased 5α-reductase activity in patients with PCOS was related to IR. |
| first_indexed | 2024-12-13T06:09:06Z |
| format | Article |
| id | doaj.art-fa5cf84c410e47deaec917c6d2067efd |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-13T06:09:06Z |
| publishDate | 2017-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-fa5cf84c410e47deaec917c6d2067efd2022-12-21T23:57:09ZengBMCReproductive Biology and Endocrinology1477-78272017-03-011511910.1186/s12958-017-0242-95α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysisChuyan Wu0Ke Wei1Zhongli Jiang2Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical UniversityMedical Service Section, the First Affiliated Hospital of Nanjing Medical UniversityDepartment of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical UniversityAbstract Background 5α-reductase activity might be important during the development of polycystic ovary syndrome (PCOS). However, the changes of 5α-reductase activity in PCOS subjects and the relationship between 5α-reductase activity and body mass index (BMI), insulin resistance (IR) remain largely unknown. Methods We performed a meta-analysis to examine 5α-reductase activity in women with PCOS; exploratory subgroup analyses were also performed. Results Five articles (with 356 cases and 236 controls) reporting 5α-reductase activity in patients with PCOS were selected for the meta-analysis. We observed significantly higher ratios of 5αTHF/THF (5α-reduced tetrahydrocortisol to 5β-reduced tetrahydrocortisol) and An/Et (androsteroneto/etiocholanolone) levels, which were used to assess 5α-reductase activity, among the patients with PCOS, [standardized mean differences (SMD) =0.43, 95%confidence intervals (95%CI) =0.25–0.61, P < 0.00001; SMD = 0.86, 95% CI = 0.29–1.44, P = 0.003]. We observed significant heterogeneity between studies for An/Et (I2 = 89% and P < 0.00001). According to the group analysis, women with PCOS exhibited increased 5α-reductase activity which was significantly associated with homeostasis model assessment of insulin resistance (HOMA-IR) regardless of obesity. Conclusions 5α-reductase activity was enhanced in women with PCOS. Increased 5α-reductase activity in patients with PCOS was related to IR.http://link.springer.com/article/10.1186/s12958-017-0242-95α-ReductasePolycystic ovary syndromeBody mass indexInsulin resistance |
| spellingShingle | Chuyan Wu Ke Wei Zhongli Jiang 5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis Reproductive Biology and Endocrinology 5α-Reductase Polycystic ovary syndrome Body mass index Insulin resistance |
| title | 5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis |
| title_full | 5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis |
| title_fullStr | 5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis |
| title_full_unstemmed | 5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis |
| title_short | 5α-reductase activity in women with polycystic ovary syndrome: a systematic review and meta-analysis |
| title_sort | 5α reductase activity in women with polycystic ovary syndrome a systematic review and meta analysis |
| topic | 5α-Reductase Polycystic ovary syndrome Body mass index Insulin resistance |
| url | http://link.springer.com/article/10.1186/s12958-017-0242-9 |
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