Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion
Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-09-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/5/9/1664 |
| _version_ | 1811302471336722432 |
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| author | Bianca Kloos Katharina F. Kubatzky Dagmar Hildebrand |
| author_facet | Bianca Kloos Katharina F. Kubatzky Dagmar Hildebrand |
| author_sort | Bianca Kloos |
| collection | DOAJ |
| description | Pasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel. |
| first_indexed | 2024-04-13T07:29:43Z |
| format | Article |
| id | doaj.art-fa5db2abc46d4331aa43a4d614d69cc3 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T07:29:43Z |
| publishDate | 2013-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-fa5db2abc46d4331aa43a4d614d69cc32022-12-22T02:56:24ZengMDPI AGToxins2072-66512013-09-01591664168110.3390/toxins5091664Signaling Cascades of Pasteurella multocida Toxin in Immune EvasionBianca KloosKatharina F. KubatzkyDagmar HildebrandPasteurella multocida toxin (PMT) is a protein toxin found in toxigenic strains of Pasteurella multocida. PMT is the causative agent for atrophic rhinitis in pigs, a disease characterized by loss of nasal turbinate bones due to an inhibition of osteoblast function and an increase in osteoclast activity and numbers. Apart from this, PMT acts as a strong mitogen, protects from apoptosis and has an impact on the differentiation and function of immune cells. Many signaling pathways have been elucidated, however, the effect of these signaling cascades as a means to subvert the host’s immune system are just beginning to unravel.http://www.mdpi.com/2072-6651/5/9/1664bacterial toxinPasteurella multocidaimmune evasionsignal transductionosteoclastosteoimmunologycarcinogenesis |
| spellingShingle | Bianca Kloos Katharina F. Kubatzky Dagmar Hildebrand Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion Toxins bacterial toxin Pasteurella multocida immune evasion signal transduction osteoclast osteoimmunology carcinogenesis |
| title | Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion |
| title_full | Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion |
| title_fullStr | Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion |
| title_full_unstemmed | Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion |
| title_short | Signaling Cascades of Pasteurella multocida Toxin in Immune Evasion |
| title_sort | signaling cascades of pasteurella multocida toxin in immune evasion |
| topic | bacterial toxin Pasteurella multocida immune evasion signal transduction osteoclast osteoimmunology carcinogenesis |
| url | http://www.mdpi.com/2072-6651/5/9/1664 |
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