The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide
This work includes green synthesis of magnesium oxide nanoparticles (MgO NPs) by using Alstoniascholaris, which is indigenous to many countries such as China, Australia, Sri Lanka, Pakistan, and India. Its pharmacological activities include antidiabetic, antioxidant, anticancer, analgesic, antitussi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2022.875163/full |
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| author | Sammia Shahid Anam Ejaz Mohsin Javed Sana Mansoor Shahid Iqbal Eslam B. Elkaeed Rami M. Alzhrani Hashem O. Alsaab Nasser S. Awwad Hala A. Ibrahium Hala A. Ibrahium Urooj Fatima Sabah Zaman Muhammad Nazim Sarwar |
| author_facet | Sammia Shahid Anam Ejaz Mohsin Javed Sana Mansoor Shahid Iqbal Eslam B. Elkaeed Rami M. Alzhrani Hashem O. Alsaab Nasser S. Awwad Hala A. Ibrahium Hala A. Ibrahium Urooj Fatima Sabah Zaman Muhammad Nazim Sarwar |
| author_sort | Sammia Shahid |
| collection | DOAJ |
| description | This work includes green synthesis of magnesium oxide nanoparticles (MgO NPs) by using Alstoniascholaris, which is indigenous to many countries such as China, Australia, Sri Lanka, Pakistan, and India. Its pharmacological activities include antidiabetic, antioxidant, anticancer, analgesic, antitussive, and anti-diarrheal activities. In this study, the antioxidant and anti-inflammatory activities of bio-inspired magnesium oxide nanoparticles, MgO NPs, were investigated. MgO NPs were prepared by using the leaf extract of Alstonia scholaris, followed by characterization using EDX, XRD, and SEM techniques. The crystallite size of magnesium oxide nanoparticles was 19.57 nm. XRD analysis confirmed the crystallinity and the purity of MgO NPs. Anti-inflammatory activity was carried out to observe inhibition of protein denaturation. Since the IC50 of MgO nanoparticles was lower than the standard, it was found to be more effective. IC50 values were compared, and results reveal that bioinspired MgO NPs undergo more scavenging of free radicals than standard (ascorbic acid) MgO NPs. These MgO nanoparticles are useful in cosmetics such as scrubs, moisturizers, and an active ingredient in microdermabrasion and in formulating effective drugs for maintaining the protein structure of the body, which will reduce inflammation. |
| first_indexed | 2024-12-10T10:27:24Z |
| format | Article |
| id | doaj.art-fa5de8845b3246468a5c5ff5ae77a20a |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-12-10T10:27:24Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-fa5de8845b3246468a5c5ff5ae77a20a2022-12-22T01:52:41ZengFrontiers Media S.A.Frontiers in Materials2296-80162022-04-01910.3389/fmats.2022.875163875163The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium OxideSammia Shahid0Anam Ejaz1Mohsin Javed2Sana Mansoor3Shahid Iqbal4Eslam B. Elkaeed5Rami M. Alzhrani6Hashem O. Alsaab7Nasser S. Awwad8Hala A. Ibrahium9Hala A. Ibrahium10Urooj Fatima11Sabah Zaman12Muhammad Nazim Sarwar13Department of Chemistry, School of Science, University of Management and Technology, Lahore, PakistanDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, PakistanDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, PakistanDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, PakistanDepartment of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST), Islamabad, PakistanDepartment of Pharmaceutical Sciences, College of Pharmacy, Almaarefa University, Riyadh, Saudi ArabiaDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi ArabiaDepartment of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi ArabiaChemistry Department, Faculty of Science, King Khalid University, Abha, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha, Saudi ArabiaDepartment of Semi Pilot Plant, Nuclear Materials Authority, Cairo, EgyptDepartment of Chemistry, School of Science, University of Management and Technology, Lahore, PakistanIbn-E-Sina Institute of Technology, Islamabad, PakistanIbn-E-Sina Institute of Technology, Islamabad, PakistanThis work includes green synthesis of magnesium oxide nanoparticles (MgO NPs) by using Alstoniascholaris, which is indigenous to many countries such as China, Australia, Sri Lanka, Pakistan, and India. Its pharmacological activities include antidiabetic, antioxidant, anticancer, analgesic, antitussive, and anti-diarrheal activities. In this study, the antioxidant and anti-inflammatory activities of bio-inspired magnesium oxide nanoparticles, MgO NPs, were investigated. MgO NPs were prepared by using the leaf extract of Alstonia scholaris, followed by characterization using EDX, XRD, and SEM techniques. The crystallite size of magnesium oxide nanoparticles was 19.57 nm. XRD analysis confirmed the crystallinity and the purity of MgO NPs. Anti-inflammatory activity was carried out to observe inhibition of protein denaturation. Since the IC50 of MgO nanoparticles was lower than the standard, it was found to be more effective. IC50 values were compared, and results reveal that bioinspired MgO NPs undergo more scavenging of free radicals than standard (ascorbic acid) MgO NPs. These MgO nanoparticles are useful in cosmetics such as scrubs, moisturizers, and an active ingredient in microdermabrasion and in formulating effective drugs for maintaining the protein structure of the body, which will reduce inflammation.https://www.frontiersin.org/articles/10.3389/fmats.2022.875163/fullMgO nanoparticlesgreen synthesisAlstonia scholarisantioxidant activityanti-inflammatory activity |
| spellingShingle | Sammia Shahid Anam Ejaz Mohsin Javed Sana Mansoor Shahid Iqbal Eslam B. Elkaeed Rami M. Alzhrani Hashem O. Alsaab Nasser S. Awwad Hala A. Ibrahium Hala A. Ibrahium Urooj Fatima Sabah Zaman Muhammad Nazim Sarwar The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide Frontiers in Materials MgO nanoparticles green synthesis Alstonia scholaris antioxidant activity anti-inflammatory activity |
| title | The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide |
| title_full | The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide |
| title_fullStr | The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide |
| title_full_unstemmed | The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide |
| title_short | The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide |
| title_sort | anti inflammatory and free radical scavenging activities of bio inspired nano magnesium oxide |
| topic | MgO nanoparticles green synthesis Alstonia scholaris antioxidant activity anti-inflammatory activity |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2022.875163/full |
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