Studying additive effects of combining rTMS with cognitive control training: a pilot investigation
BackgroundRepetitive transcranial magnetic stimulation (rTMS) on the dorsolateral prefrontal cortex (DLPFC) is an effective treatment for depression that has been proposed to work via the enhancement of cognitive control. Cognitive control training (CCT) can also alleviate depression by relying on D...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1201344/full |
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| author | Iris Dalhuisen Iris Dalhuisen Céline Schutte Bob Bramson Bob Bramson Karin Roelofs Karin Roelofs Philip van Eijndhoven Philip van Eijndhoven Indira Tendolkar Indira Tendolkar |
| author_facet | Iris Dalhuisen Iris Dalhuisen Céline Schutte Bob Bramson Bob Bramson Karin Roelofs Karin Roelofs Philip van Eijndhoven Philip van Eijndhoven Indira Tendolkar Indira Tendolkar |
| author_sort | Iris Dalhuisen |
| collection | DOAJ |
| description | BackgroundRepetitive transcranial magnetic stimulation (rTMS) on the dorsolateral prefrontal cortex (DLPFC) is an effective treatment for depression that has been proposed to work via the enhancement of cognitive control. Cognitive control training (CCT) can also alleviate depression by relying on DLPFC activation. As the additive effects of rTMS and CCT are unclear, we set out to conduct a within-subject pilot study in healthy controls.MethodsSeventeen participants received two sessions of individualized resting-state connectivity-guided high-frequency rTMS, while randomly performing CCT or a control task. After each session, a negative mood was induced.ResultsWe found effects on mood and cognitive control after rTMS + CCT as well as rTMS + control, which were indiscriminative between conditions. Based on the statistical evidence for the absence of an additive effect of CCT, we did not perform a full study.ConclusionOur results demonstrate no differential effects of single sessions combining rTMS and CCT in a healthy population, even with the methodological improvement of individualized neuronavigation. The improvement in cognitive control seen in both conditions could indicate that a simple cognitive task is sufficient when studying additive rTMS effects. Future studies should focus on augmenting the effects of various cognitive tasks and compare the present interventions with rTMS or cognitive tasks alone. |
| first_indexed | 2024-03-12T20:58:36Z |
| format | Article |
| id | doaj.art-fa5effe1f880438bb83eff664c18e962 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-03-12T20:58:36Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-fa5effe1f880438bb83eff664c18e9622023-07-31T13:06:23ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-07-011710.3389/fnhum.2023.12013441201344Studying additive effects of combining rTMS with cognitive control training: a pilot investigationIris Dalhuisen0Iris Dalhuisen1Céline Schutte2Bob Bramson3Bob Bramson4Karin Roelofs5Karin Roelofs6Philip van Eijndhoven7Philip van Eijndhoven8Indira Tendolkar9Indira Tendolkar10Department of Psychiatry, Radboud University Medical Center, Nijmegen, NetherlandsDonders Institute for Brain Cognition and Behavior, Radboud University, Nijmegen, NetherlandsDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, NetherlandsDonders Institute for Brain Cognition and Behavior, Radboud University, Nijmegen, NetherlandsBehavioral Science Institute, Radboud University, Nijmegen, NetherlandsDonders Institute for Brain Cognition and Behavior, Radboud University, Nijmegen, NetherlandsBehavioral Science Institute, Radboud University, Nijmegen, NetherlandsDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, NetherlandsDonders Institute for Brain Cognition and Behavior, Radboud University, Nijmegen, NetherlandsDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, NetherlandsDonders Institute for Brain Cognition and Behavior, Radboud University, Nijmegen, NetherlandsBackgroundRepetitive transcranial magnetic stimulation (rTMS) on the dorsolateral prefrontal cortex (DLPFC) is an effective treatment for depression that has been proposed to work via the enhancement of cognitive control. Cognitive control training (CCT) can also alleviate depression by relying on DLPFC activation. As the additive effects of rTMS and CCT are unclear, we set out to conduct a within-subject pilot study in healthy controls.MethodsSeventeen participants received two sessions of individualized resting-state connectivity-guided high-frequency rTMS, while randomly performing CCT or a control task. After each session, a negative mood was induced.ResultsWe found effects on mood and cognitive control after rTMS + CCT as well as rTMS + control, which were indiscriminative between conditions. Based on the statistical evidence for the absence of an additive effect of CCT, we did not perform a full study.ConclusionOur results demonstrate no differential effects of single sessions combining rTMS and CCT in a healthy population, even with the methodological improvement of individualized neuronavigation. The improvement in cognitive control seen in both conditions could indicate that a simple cognitive task is sufficient when studying additive rTMS effects. Future studies should focus on augmenting the effects of various cognitive tasks and compare the present interventions with rTMS or cognitive tasks alone.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1201344/fullrepetitive transcranial magnetic stimulationcognitive control trainingdepressionneuronavigationmood induction |
| spellingShingle | Iris Dalhuisen Iris Dalhuisen Céline Schutte Bob Bramson Bob Bramson Karin Roelofs Karin Roelofs Philip van Eijndhoven Philip van Eijndhoven Indira Tendolkar Indira Tendolkar Studying additive effects of combining rTMS with cognitive control training: a pilot investigation Frontiers in Human Neuroscience repetitive transcranial magnetic stimulation cognitive control training depression neuronavigation mood induction |
| title | Studying additive effects of combining rTMS with cognitive control training: a pilot investigation |
| title_full | Studying additive effects of combining rTMS with cognitive control training: a pilot investigation |
| title_fullStr | Studying additive effects of combining rTMS with cognitive control training: a pilot investigation |
| title_full_unstemmed | Studying additive effects of combining rTMS with cognitive control training: a pilot investigation |
| title_short | Studying additive effects of combining rTMS with cognitive control training: a pilot investigation |
| title_sort | studying additive effects of combining rtms with cognitive control training a pilot investigation |
| topic | repetitive transcranial magnetic stimulation cognitive control training depression neuronavigation mood induction |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1201344/full |
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