Elevated expression of Toll-like receptor 4 and cytokines in both serum and myometrium at term may serve as promising biomarkers for uterine activation preceding labor

Elevated expression of Toll-like receptor 4 and cytokines in both serum and myometrium at term may serve as promising biomarkers for uterine activation preceding labor

ObjectiveIncreased inflammation and cytokine levels are considered risk factors and promoters of preterm birth (PTB). However, the regulatory mechanism of pregnancy-related inflammation remains unclear. Toll-like receptor 4 (TLR4) plays a critical role in inflammatory responses in various diseases....

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Bibliographic Details
Main Authors: Zixi Chen, Jinpeng Li, Wenjuan Xu, Xiaomei Wu, Fenfen Xiang, Xiaoxiao Li, Mengzhe Zhang, Jin Zheng, Xiangdong Kang, Rong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Endocrinology
Subjects:
uterus activation
TLR4
cytokines
inflammation
MAPK/NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1255925/full

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