Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019
Introduction:Trichomoniasis is the most common non-viral sexually transmitted infection which is associated with several complications. Propolis is a bee product and contains tanen, flavonoids and volatile oils, so it has antiprasitic activity. This study was performed with aim to compare the effect...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
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Mashhad University of Medical Sciences
2021-02-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_17829_5848f4f0e5028773b2511fafed4ad180.pdf |
| _version_ | 1811223886003437568 |
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| author | Seyede Shadi Taghavian Afsaneh Yekdaneh Hatav Ghasemi Tehrani Mahboubeh Valiani Siamak Alian Reza Beiranvand |
| author_facet | Seyede Shadi Taghavian Afsaneh Yekdaneh Hatav Ghasemi Tehrani Mahboubeh Valiani Siamak Alian Reza Beiranvand |
| author_sort | Seyede Shadi Taghavian |
| collection | DOAJ |
| description | Introduction:Trichomoniasis is the most common non-viral sexually transmitted infection which is associated with several complications. Propolis is a bee product and contains tanen, flavonoids and volatile oils, so it has antiprasitic activity. This study was performed with aim to compare the effect of propolis gel and metronidazole tablet on dyspareunia.
Methods:This clinical trial study was conducted in 2019 on 102 non-pregnant married women with complains of Trichomoniasis clinical symptoms referred to the gynecology clinics in Isfahan. They were divided into two groups of experiment (propolis gel) and control (metronidazole tablet). Participants were treated for 7 days. Dyspareunia was assessed using the visual pain scale (VAS) with a range of 0-10. Data were analyzed by SPSS software (version 20) and independent T-test, fisher exact test, ANCOVA and Chi-square tests. P<0.05 was considered statistically significant.
Results: During all steps of the study, no significant differences were observed between the two groups in type and mean severity of pain. However, after adjustment of dyspareunia pre-intervention and 2 weeks after the intervention, the score of dyspareunia in the experiment group was 0.882 lower than the control group; this difference was statistically significant (P=0.009). In the experiment group, all of participants with post coital bleeding/spotting were completely treated, while no improvement was observed in the control group.
Conclusion: Vaginal gel containing propolis extract has positive therapeutic effect on dyspareunia. It has least effect on the vaginal epithelium, without GI and neurologic side effects. |
| first_indexed | 2024-04-12T08:40:11Z |
| format | Article |
| id | doaj.art-fa5f7fc057e54f0aad92f46073946e7c |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-12T08:40:11Z |
| publishDate | 2021-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-fa5f7fc057e54f0aad92f46073946e7c2022-12-22T03:39:55ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632021-02-012312768510.22038/ijogi.2021.1782917829Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019Seyede Shadi Taghavian0Afsaneh Yekdaneh1Hatav Ghasemi Tehrani2Mahboubeh Valiani3Siamak Alian4Reza Beiranvand5M.Sc. Student of Midwifery, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.Assistant professor, Department of Pharmacognosy, Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.Assistant professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Assistant Professor, Department of Midwifery and Reproductive Health, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.Equivalent PhD in traditional and complementary medicine, R&D member of daroodarman pharmacy company, Isfahan, Iran.PhD student of Epidemiology, School of Health, Tehran University of Medical Sciences, Tehran, Iran.Introduction:Trichomoniasis is the most common non-viral sexually transmitted infection which is associated with several complications. Propolis is a bee product and contains tanen, flavonoids and volatile oils, so it has antiprasitic activity. This study was performed with aim to compare the effect of propolis gel and metronidazole tablet on dyspareunia. Methods:This clinical trial study was conducted in 2019 on 102 non-pregnant married women with complains of Trichomoniasis clinical symptoms referred to the gynecology clinics in Isfahan. They were divided into two groups of experiment (propolis gel) and control (metronidazole tablet). Participants were treated for 7 days. Dyspareunia was assessed using the visual pain scale (VAS) with a range of 0-10. Data were analyzed by SPSS software (version 20) and independent T-test, fisher exact test, ANCOVA and Chi-square tests. P<0.05 was considered statistically significant. Results: During all steps of the study, no significant differences were observed between the two groups in type and mean severity of pain. However, after adjustment of dyspareunia pre-intervention and 2 weeks after the intervention, the score of dyspareunia in the experiment group was 0.882 lower than the control group; this difference was statistically significant (P=0.009). In the experiment group, all of participants with post coital bleeding/spotting were completely treated, while no improvement was observed in the control group. Conclusion: Vaginal gel containing propolis extract has positive therapeutic effect on dyspareunia. It has least effect on the vaginal epithelium, without GI and neurologic side effects.https://ijogi.mums.ac.ir/article_17829_5848f4f0e5028773b2511fafed4ad180.pdfdyspareuniapropolistrichomoniasistrichomonas vaginalis |
| spellingShingle | Seyede Shadi Taghavian Afsaneh Yekdaneh Hatav Ghasemi Tehrani Mahboubeh Valiani Siamak Alian Reza Beiranvand Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019 Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān dyspareunia propolis trichomoniasis trichomonas vaginalis |
| title | Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019 |
| title_full | Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019 |
| title_fullStr | Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019 |
| title_full_unstemmed | Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019 |
| title_short | Effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at Isfahan in 2019 |
| title_sort | effect of vaginal gel containing propolis extract and oral metronidazole pill on dyspareunia in woman with trichomoniasis at isfahan in 2019 |
| topic | dyspareunia propolis trichomoniasis trichomonas vaginalis |
| url | https://ijogi.mums.ac.ir/article_17829_5848f4f0e5028773b2511fafed4ad180.pdf |
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