Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature
Abstract The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment. Previous studies have focused...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01604-7 |
| _version_ | 1827382379675648000 |
|---|---|
| author | Shangkun Zhao Zhi Qiao Roman Pfeifer Hans-Christoph Pape Keya Mao Hai Tang Bin Meng Songfeng Chen Hongjian Liu |
| author_facet | Shangkun Zhao Zhi Qiao Roman Pfeifer Hans-Christoph Pape Keya Mao Hai Tang Bin Meng Songfeng Chen Hongjian Liu |
| author_sort | Shangkun Zhao |
| collection | DOAJ |
| description | Abstract The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment. Previous studies have focused on the beneficial role of SASP during embryonic development, wound healing, tissue healing in general, immunoregulation properties, and cancer. However, some recent studies have identified several negative effects of SASP on fracture healing. Senolytics is a drug that selectively eliminates senescent cells. Senolytics can inhibit the function of senescent cells and SASP, which has been found to have positive effects on a variety of aging-related diseases. At the same time, recent data suggest that removing senescent cells may promote fracture healing. Here, we reviewed the latest research progress about SASP and illustrated the inflammatory response and the influence of SASP on fracture healing. This review aims to understand the role of SASP in fracture healing, aiming to provide an important clinical prevention and treatment strategy for fracture. Clinical trials of some senolytics agents are underway and are expected to clarify the effectiveness of their targeted therapy in the clinic in the future. Meanwhile, the adverse effects of this treatment method still need further study. |
| first_indexed | 2024-03-08T14:18:43Z |
| format | Article |
| id | doaj.art-fa60692785ea4f38acd9bb35bb5966f7 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-08T14:18:43Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-fa60692785ea4f38acd9bb35bb5966f72024-01-14T12:16:36ZengBMCEuropean Journal of Medical Research2047-783X2024-01-0129111210.1186/s40001-023-01604-7Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literatureShangkun Zhao0Zhi Qiao1Roman Pfeifer2Hans-Christoph Pape3Keya Mao4Hai Tang5Bin Meng6Songfeng Chen7Hongjian Liu8Department of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Traumatology, University Hospital of ZurichDepartment of Traumatology, University Hospital of ZurichChinese PLA General Hospital BeijingBeijing Friendship HospitalFirst Affiliated Hospital of Soochow UniversityDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou UniversityAbstract The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment. Previous studies have focused on the beneficial role of SASP during embryonic development, wound healing, tissue healing in general, immunoregulation properties, and cancer. However, some recent studies have identified several negative effects of SASP on fracture healing. Senolytics is a drug that selectively eliminates senescent cells. Senolytics can inhibit the function of senescent cells and SASP, which has been found to have positive effects on a variety of aging-related diseases. At the same time, recent data suggest that removing senescent cells may promote fracture healing. Here, we reviewed the latest research progress about SASP and illustrated the inflammatory response and the influence of SASP on fracture healing. This review aims to understand the role of SASP in fracture healing, aiming to provide an important clinical prevention and treatment strategy for fracture. Clinical trials of some senolytics agents are underway and are expected to clarify the effectiveness of their targeted therapy in the clinic in the future. Meanwhile, the adverse effects of this treatment method still need further study.https://doi.org/10.1186/s40001-023-01604-7Fracture healingBoneSenescenceSASPSenolytics |
| spellingShingle | Shangkun Zhao Zhi Qiao Roman Pfeifer Hans-Christoph Pape Keya Mao Hai Tang Bin Meng Songfeng Chen Hongjian Liu Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature European Journal of Medical Research Fracture healing Bone Senescence SASP Senolytics |
| title | Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature |
| title_full | Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature |
| title_fullStr | Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature |
| title_full_unstemmed | Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature |
| title_short | Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature |
| title_sort | modulation of fracture healing by senescence associated secretory phenotype sasp a narrative review of the current literature |
| topic | Fracture healing Bone Senescence SASP Senolytics |
| url | https://doi.org/10.1186/s40001-023-01604-7 |
| work_keys_str_mv | AT shangkunzhao modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT zhiqiao modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT romanpfeifer modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT hanschristophpape modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT keyamao modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT haitang modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT binmeng modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT songfengchen modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature AT hongjianliu modulationoffracturehealingbysenescenceassociatedsecretoryphenotypesaspanarrativereviewofthecurrentliterature |