The ST2+ Treg/amphiregulin axis protects from immune-mediated hepatitis

The ST2+ Treg/amphiregulin axis protects from immune-mediated hepatitis

IntroductionThe alarmin IL-33 has been implicated in the pathology of immune-mediated liver diseases. IL-33 activates regulatory T cells (Tregs) and type 2 innate lymphoid cells (ILC2s) expressing the IL-33 receptor ST2. We have previously shown that endogenous IL-33/ST2 signaling activates ILC2s th...

Full description

Bibliographic Details
Main Authors:	Selina Wachtendorf, Fitriasari Jonin, Aaron Ochel, Fabian Heinrich, Astrid M. Westendorf, Gisa Tiegs, Katrin Neumann
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Immunology
Subjects:	Treg maintenance and function ST2+ Tregs ILC2s amphiregulin hepatic immunoregulation liver inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351405/full

Similar Items

Osthole alleviates food allergy by blocking IL-33/ST2 pathway and targeting ILC2-CD4+T response
by: Lei Wang, et al.
Published: (2023-09-01)

IL-33 increases ST2+ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner
by: E.C. Halvorsen, et al.
Published: (2019-02-01)

Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis
by: Hirohito Abo, et al.
Published: (2019-03-01)

Physical Exercise Induces Immunoregulation of TREG, M2, and pDCs in a Lung Allergic Inflammation Model
by: Paula Fernandes, et al.
Published: (2019-05-01)

Do natural Treg become activated to antigen specific Treg in transplantation and in autoimmunity?
by: Bruce Milne Hall, et al.
Published: (2013-08-01)

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss
by: Luguang Chen, et al.
Published: (2017-12-01)

Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation
by: Zhao Gao, et al.
Published: (2021-09-01)

Harnessing CD8<sup>+</sup>CD28<sup>−</sup> Regulatory T Cells as a Tool to Treat Autoimmune Disease
by: Sabrina Ceeraz, et al.
Published: (2021-11-01)

Regulation of Treg Cell Metabolism and Function in Non-Lymphoid Tissues
by: Kai Yang, et al.
Published: (2022-06-01)

Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity
by: Andrzej Chruscinski, et al.
Published: (2015-07-01)

Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells
by: Chuanjian Lu, et al.
Published: (2018-02-01)

Mangiferin Attenuates Murine Lupus Nephritis by Inducing CD4+Foxp3+ Regulatory T Cells via Suppression of mTOR Signaling
by: Chun-Ling Liang, et al.
Published: (2018-10-01)

Difference between CD25+Tregs and Helios+Tregs in a murine model of allergic rhinitis
by: Yun-Xiu Wang, et al.
Published: (2021-09-01)

Regulatory Mechanisms of IL-33-ST2-Mediated Allergic Inflammation
by: Hiroaki Takatori, et al.
Published: (2018-09-01)

The positive correlation between amphiregulin and insulin resistance
by: Yun Zhao, et al.
Published: (2025-03-01)

Mini-Review: Tregs as a Tool for Therapy—Obvious and Non-Obvious Challenges and Solutions
by: Elena I. Morgun, et al.
Published: (2024-10-01)

Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients
by: Serena De Matteis, et al.
Published: (2018-06-01)

Amphiregulin-producing TH2 cells facilitate esophageal fibrosis of eosinophilic esophagitis
by: Tatsuya Kaneko, MD, PhD, et al.
Published: (2024-08-01)

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells
by: Susanne Herppich, et al.
Published: (2019-10-01)

Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair
by: Ruijing Zhang, et al.
Published: (2021-02-01)

Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer
by: Byung-Seok Kim, et al.
Published: (2020-01-01)

Ethyl Pyruvate Promotes Proliferation of Regulatory T Cells by Increasing Glycolysis
by: Ivan Koprivica, et al.
Published: (2020-09-01)

Expression of Amphiregulin in Enchondromas and Central Chondrosarcomas
by: Daniele Moraes Losada, et al.
Published: (2021-08-01)

Dickkopf-1 and Amphiregulin as Novel Biomarkers and Potential Therapeutic Targets in Hepatocellular Carcinoma
by: Abeer E. Awad, et al.
Published: (2019-07-01)

IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica
by: Bai Y, et al.
Published: (2021-11-01)

Tissue Tregs and Maintenance of Tissue Homeostasis
by: Qing Shao, et al.
Published: (2021-08-01)

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
by: Matteo Doglio, et al.
Published: (2022-11-01)

CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications
by: Motahareh Arjomandnejad, et al.
Published: (2022-01-01)

The immunomodulation role of Th17 and Treg in renal transplantation
by: Dan-Lei Huang, et al.
Published: (2023-02-01)

TNFR2: The new Treg switch?
by: José L. Cohen, et al.
Published: (2018-01-01)

The Dynamic Role of FOXP3+ Tregs and Their Potential Therapeutic Applications During SARS-CoV-2 Infection
by: Zhan Xu, et al.
Published: (2022-07-01)

Potential correlation of allograft infiltrating group 2 innate lymphoid cells with acute rejection after liver transplantation
by: Jie Sun, et al.
Published: (2022-07-01)

IMMUNOLOGICAL MEMORY: THE ROLE OF REGULATORY CELLS (TREGS)
by: E. K. Oleinik, et al.
Published: (2018-11-01)

ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway
by: Xiaofei Huang, et al.
Published: (2025-01-01)

Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells
by: Qiaohuang Zeng, et al.
Published: (2019-04-01)

Amphiregulin (AREG) and Epiregulin (EREG) Gene Expression as Predictor for Overall Survival (OS) in Oxaliplatin/Fluoropyrimidine Plus Bevacizumab Treated mCRC Patients—Analysis of the Phase III AIO KRK-0207 Trial
by: Sebastian Stintzing, et al.
Published: (2018-11-01)

Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma
by: Mahmood Yaseen Hachim, et al.
Published: (2020-10-01)

Investigation of the Molecular Evolution of Treg Suppression Mechanisms Indicates a Convergent Origin
by: Suniti Bhaumik, et al.
Published: (2023-01-01)

Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development
by: Yuetao Zhou, et al.
Published: (2016-08-01)

Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis
by: Vishnu Hosur, et al.
Published: (2017-08-01)