Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome
Abstract Background Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, the question of whether immune par...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13054-021-03558-w |
| _version_ | 1818924852579401728 |
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| author | Fabienne Venet Martin Cour Thomas Rimmelé Sebastien Viel Hodane Yonis Remy Coudereau Camille Amaz Paul Abraham Céline Monard Jean-Sebastien Casalegno Karen Brengel-Pesce Anne-Claire Lukaszewicz Laurent Argaud Guillaume Monneret the RICO study group |
| author_facet | Fabienne Venet Martin Cour Thomas Rimmelé Sebastien Viel Hodane Yonis Remy Coudereau Camille Amaz Paul Abraham Céline Monard Jean-Sebastien Casalegno Karen Brengel-Pesce Anne-Claire Lukaszewicz Laurent Argaud Guillaume Monneret the RICO study group |
| author_sort | Fabienne Venet |
| collection | DOAJ |
| description | Abstract Background Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, the question of whether immune parameters may drive or associate with delayed unfavorable outcome in these critically ill patients remains unsolved. Methods We present a dynamic description of immuno-inflammatory derangements in 64 critically ill COVID-19 patients including plasma IFNα2 levels and IFN-stimulated genes (ISG) score measurements. Results ARDS patients presented with persistently decreased lymphocyte count and mHLA-DR expression and increased cytokine levels. Type-I IFN response was initially induced with elevation of IFNα2 levels and ISG score followed by a rapid decrease over time. Survivors and non-survivors presented with apparent common immune responses over the first 3 weeks after ICU admission mixing gradual return to normal values of cellular markers and progressive decrease of cytokines levels including IFNα2. Only plasma TNF-α presented with a slow increase over time and higher values in non-survivors compared with survivors. This paralleled with an extremely high occurrence of secondary infections in COVID-19 patients with ARDS. Conclusions Occurrence of ARDS in response to SARS-CoV2 infection appears to be strongly associated with the intensity of immune alterations upon ICU admission of COVID-19 patients. In these critically ill patients, immune profile presents with similarities with the delayed step of immunosuppression described in bacterial sepsis. |
| first_indexed | 2024-12-20T02:31:55Z |
| format | Article |
| id | doaj.art-fa62ede68eff4a0d8ff828aa95e0774b |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-20T02:31:55Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-fa62ede68eff4a0d8ff828aa95e0774b2022-12-21T19:56:34ZengBMCCritical Care1364-85352021-04-0125111210.1186/s13054-021-03558-wLongitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndromeFabienne Venet0Martin Cour1Thomas Rimmelé2Sebastien Viel3Hodane Yonis4Remy Coudereau5Camille Amaz6Paul Abraham7Céline Monard8Jean-Sebastien Casalegno9Karen Brengel-Pesce10Anne-Claire Lukaszewicz11Laurent Argaud12Guillaume Monneret13the RICO study groupImmunology Laboratory, Hôpital E. Herriot - Hospices Civils de LyonMedical Intensive Care Department, Edouard Herriot Hospital, Hospices Civils de LyonJoint Research Unit HCL-bioMérieux, EA 7426 “Pathophysiology of Injury-Induced Immunosuppression” (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux)Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université ClaudeMedical Intensive Care Department, Croix-Rousse University Hospital, Hospices Civils de LyonImmunology Laboratory, Hôpital E. Herriot - Hospices Civils de LyonCentre d’Investigation Clinique de Lyon (CIC 1407 Inserm), Hospices Civils de LyonAnesthesia and Critical Care Medicine Department, Edouard Herriot Hospital, Hospices Civils de LyonAnesthesia and Critical Care Medicine Department, Edouard Herriot Hospital, Hospices Civils de LyonVirology Laboratory, Croix-Rousse University Hospital, Hospices Civils de LyonJoint Research Unit HCL-bioMérieux, EA 7426 “Pathophysiology of Injury-Induced Immunosuppression” (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux)Joint Research Unit HCL-bioMérieux, EA 7426 “Pathophysiology of Injury-Induced Immunosuppression” (Université Claude Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux)Medical Intensive Care Department, Edouard Herriot Hospital, Hospices Civils de LyonImmunology Laboratory, Hôpital E. Herriot - Hospices Civils de LyonAbstract Background Since the onset of the pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, the question of whether immune parameters may drive or associate with delayed unfavorable outcome in these critically ill patients remains unsolved. Methods We present a dynamic description of immuno-inflammatory derangements in 64 critically ill COVID-19 patients including plasma IFNα2 levels and IFN-stimulated genes (ISG) score measurements. Results ARDS patients presented with persistently decreased lymphocyte count and mHLA-DR expression and increased cytokine levels. Type-I IFN response was initially induced with elevation of IFNα2 levels and ISG score followed by a rapid decrease over time. Survivors and non-survivors presented with apparent common immune responses over the first 3 weeks after ICU admission mixing gradual return to normal values of cellular markers and progressive decrease of cytokines levels including IFNα2. Only plasma TNF-α presented with a slow increase over time and higher values in non-survivors compared with survivors. This paralleled with an extremely high occurrence of secondary infections in COVID-19 patients with ARDS. Conclusions Occurrence of ARDS in response to SARS-CoV2 infection appears to be strongly associated with the intensity of immune alterations upon ICU admission of COVID-19 patients. In these critically ill patients, immune profile presents with similarities with the delayed step of immunosuppression described in bacterial sepsis.https://doi.org/10.1186/s13054-021-03558-wCOVID-19ARDSType-I IFNImmune profileImmunosuppression |
| spellingShingle | Fabienne Venet Martin Cour Thomas Rimmelé Sebastien Viel Hodane Yonis Remy Coudereau Camille Amaz Paul Abraham Céline Monard Jean-Sebastien Casalegno Karen Brengel-Pesce Anne-Claire Lukaszewicz Laurent Argaud Guillaume Monneret the RICO study group Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome Critical Care COVID-19 ARDS Type-I IFN Immune profile Immunosuppression |
| title | Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome |
| title_full | Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome |
| title_fullStr | Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome |
| title_full_unstemmed | Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome |
| title_short | Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome |
| title_sort | longitudinal assessment of ifn i activity and immune profile in critically ill covid 19 patients with acute respiratory distress syndrome |
| topic | COVID-19 ARDS Type-I IFN Immune profile Immunosuppression |
| url | https://doi.org/10.1186/s13054-021-03558-w |
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