EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2
Due to the challenges for developing vaccines in devastating pandemic situations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developing and screening of novel antiviral agents are peremptorily demanded. Herein, we developed EGYVIR as a potent immunomodulatory herbal extract with...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673558/?tool=EBI |
| _version_ | 1818399896417337344 |
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| author | Wael H. Roshdy Helmy A. Rashed Ahmed Kandeil Ahmed Mostafa Yassmin Moatasim Omnia Kutkat Noura M. Abo Shama Mokhtar R. Gomaa Ibrahim H. El-Sayed Nancy M. El Guindy Amal Naguib Ghazi Kayali Mohamed A. Ali Dong-Yan Jin |
| author_facet | Wael H. Roshdy Helmy A. Rashed Ahmed Kandeil Ahmed Mostafa Yassmin Moatasim Omnia Kutkat Noura M. Abo Shama Mokhtar R. Gomaa Ibrahim H. El-Sayed Nancy M. El Guindy Amal Naguib Ghazi Kayali Mohamed A. Ali Dong-Yan Jin |
| author_sort | Wael H. Roshdy |
| collection | DOAJ |
| description | Due to the challenges for developing vaccines in devastating pandemic situations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developing and screening of novel antiviral agents are peremptorily demanded. Herein, we developed EGYVIR as a potent immunomodulatory herbal extract with promising antiviral activity against SARS-CoV-2. It constitutes of a combination of black pepper extract with curcumin extract. The antiviral effect of EGYVIR extract is attributed to the two key phases of the disease in severe cases. First, the inhibition of the nuclear translocation of NF-kβ p50, attenuating the SARS-CoV-2 infection-associated cytokine storm. Additionally, the EGYVIR extract has an in vitro virucidal effect for SARS-CoV-2. The in vitro study of EGYVIR extract against SARS-CoV-2 on Huh-7 cell lines, revealed the potential role of NF-kβ/TNFα/IL-6 during the infection process. EGYVIR antagonizes the NF-kβ pathway in-silico and in-vitro studies. Consequently, it has the potential to hinder the release of IL-6 and TNFα, decreasing the production of essential cytokines storm elements. |
| first_indexed | 2024-12-14T07:27:58Z |
| format | Article |
| id | doaj.art-fa63c1abc24645518e928789b3c24f1f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T07:27:58Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fa63c1abc24645518e928789b3c24f1f2022-12-21T23:11:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011511EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2Wael H. RoshdyHelmy A. RashedAhmed KandeilAhmed MostafaYassmin MoatasimOmnia KutkatNoura M. Abo ShamaMokhtar R. GomaaIbrahim H. El-SayedNancy M. El GuindyAmal NaguibGhazi KayaliMohamed A. AliDong-Yan JinDue to the challenges for developing vaccines in devastating pandemic situations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), developing and screening of novel antiviral agents are peremptorily demanded. Herein, we developed EGYVIR as a potent immunomodulatory herbal extract with promising antiviral activity against SARS-CoV-2. It constitutes of a combination of black pepper extract with curcumin extract. The antiviral effect of EGYVIR extract is attributed to the two key phases of the disease in severe cases. First, the inhibition of the nuclear translocation of NF-kβ p50, attenuating the SARS-CoV-2 infection-associated cytokine storm. Additionally, the EGYVIR extract has an in vitro virucidal effect for SARS-CoV-2. The in vitro study of EGYVIR extract against SARS-CoV-2 on Huh-7 cell lines, revealed the potential role of NF-kβ/TNFα/IL-6 during the infection process. EGYVIR antagonizes the NF-kβ pathway in-silico and in-vitro studies. Consequently, it has the potential to hinder the release of IL-6 and TNFα, decreasing the production of essential cytokines storm elements.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673558/?tool=EBI |
| spellingShingle | Wael H. Roshdy Helmy A. Rashed Ahmed Kandeil Ahmed Mostafa Yassmin Moatasim Omnia Kutkat Noura M. Abo Shama Mokhtar R. Gomaa Ibrahim H. El-Sayed Nancy M. El Guindy Amal Naguib Ghazi Kayali Mohamed A. Ali Dong-Yan Jin EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2 PLoS ONE |
| title | EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2 |
| title_full | EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2 |
| title_fullStr | EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2 |
| title_full_unstemmed | EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2 |
| title_short | EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2 |
| title_sort | egyvir an immunomodulatory herbal extract with potent antiviral activity against sars cov 2 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673558/?tool=EBI |
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