Biological characteristics of cervical precancerous cell proliferation
High-grade squamous intraepithelial lesions (HSILs) are regarded as precancerous lesions that can progress to cervical carcinoma; however, it is very difficult to effectively differentiate these precancerous cells from cancerous cells based on morphology alone. Additionally, the difference between p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2019-05-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2019-0036 |
| _version_ | 1811246790561759232 |
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| author | Liu Yuzhen Cao Chengcheng Zhai Peiling Zhang Youzhong |
| author_facet | Liu Yuzhen Cao Chengcheng Zhai Peiling Zhang Youzhong |
| author_sort | Liu Yuzhen |
| collection | DOAJ |
| description | High-grade squamous intraepithelial lesions (HSILs) are regarded as precancerous lesions that can progress to cervical carcinoma; however, it is very difficult to effectively differentiate these precancerous cells from cancerous cells based on morphology alone. Additionally, the difference between precancerous cells and cancerous cells in regard to biological behaviour remains unclear. We previously cultured primary normal uterine cervical keratinocytes from human normal cervical tissue and cervical precancerous cells that were naturally infected with human papillomavirus from small-sized neoplastic cervical tissues. Here, we extended our study to further observe the in vitro proliferative characteristics of cervical precancerous cells at the cellular and molecular levels. In this study, we found that the growth rate of precancerous cells was significantly faster than that of normal cervical cells and slower than that of Caski cells. However, the proliferative capacity of such precancerous cells was similar to that of cancerous cells of the cervix at the molecular level. These results suggest that the surrounding environment of the cells may play an important role in the development of cervical cancer, which provides an important basis for the further study of precancerous and cancerous lesions of the cervix. |
| first_indexed | 2024-04-12T14:58:30Z |
| format | Article |
| id | doaj.art-fa6509888a0445a1a72b12c0c0e78423 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T14:58:30Z |
| publishDate | 2019-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-fa6509888a0445a1a72b12c0c0e784232022-12-22T03:28:09ZengDe GruyterOpen Medicine2391-54632019-05-0114136236810.1515/med-2019-0036med-2019-0036Biological characteristics of cervical precancerous cell proliferationLiu Yuzhen0Cao Chengcheng1Zhai Peiling2Zhang Youzhong3Department of Obstetrics and Gynecology, Affiliated Hospital of Weifang Medical University, Weifang261041, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Weifang Medical University, Weifang261041, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Weifang Medical University, Weifang261041, ChinaDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan250012, ChinaHigh-grade squamous intraepithelial lesions (HSILs) are regarded as precancerous lesions that can progress to cervical carcinoma; however, it is very difficult to effectively differentiate these precancerous cells from cancerous cells based on morphology alone. Additionally, the difference between precancerous cells and cancerous cells in regard to biological behaviour remains unclear. We previously cultured primary normal uterine cervical keratinocytes from human normal cervical tissue and cervical precancerous cells that were naturally infected with human papillomavirus from small-sized neoplastic cervical tissues. Here, we extended our study to further observe the in vitro proliferative characteristics of cervical precancerous cells at the cellular and molecular levels. In this study, we found that the growth rate of precancerous cells was significantly faster than that of normal cervical cells and slower than that of Caski cells. However, the proliferative capacity of such precancerous cells was similar to that of cancerous cells of the cervix at the molecular level. These results suggest that the surrounding environment of the cells may play an important role in the development of cervical cancer, which provides an important basis for the further study of precancerous and cancerous lesions of the cervix.https://doi.org/10.1515/med-2019-0036biological behaviourcervixproliferationprecancerous conditions |
| spellingShingle | Liu Yuzhen Cao Chengcheng Zhai Peiling Zhang Youzhong Biological characteristics of cervical precancerous cell proliferation Open Medicine biological behaviour cervix proliferation precancerous conditions |
| title | Biological characteristics of cervical precancerous cell proliferation |
| title_full | Biological characteristics of cervical precancerous cell proliferation |
| title_fullStr | Biological characteristics of cervical precancerous cell proliferation |
| title_full_unstemmed | Biological characteristics of cervical precancerous cell proliferation |
| title_short | Biological characteristics of cervical precancerous cell proliferation |
| title_sort | biological characteristics of cervical precancerous cell proliferation |
| topic | biological behaviour cervix proliferation precancerous conditions |
| url | https://doi.org/10.1515/med-2019-0036 |
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