Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy
Background: We evaluated the prognostic factors of metastatic testicular non-seminomatous germ cell tumor (NSGCT) after chemotherapy. Materials and methods: Data from 20 metastatic testicular NSGCT patients were retrospectively collected between January 2002 and December 2015. The evaluation of prog...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-09-01
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| Series: | Journal of Cancer Research and Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2311300617301519 |
| _version_ | 1818137856724434944 |
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| author | Tzu-Yao Liao Chuang-Chi Liaw Cheng-Keng Chuang Ying-Hsu Chang Cheng-Lung Hsu Meng-Ting Peng John Wen-Cheng Chang |
| author_facet | Tzu-Yao Liao Chuang-Chi Liaw Cheng-Keng Chuang Ying-Hsu Chang Cheng-Lung Hsu Meng-Ting Peng John Wen-Cheng Chang |
| author_sort | Tzu-Yao Liao |
| collection | DOAJ |
| description | Background: We evaluated the prognostic factors of metastatic testicular non-seminomatous germ cell tumor (NSGCT) after chemotherapy. Materials and methods: Data from 20 metastatic testicular NSGCT patients were retrospectively collected between January 2002 and December 2015. The evaluation of prognostic factors included age, pulmonary metastasis, cancer stage, International Germ Cell Cancer Collaborative Group (IGCCCG) classification, and histology. Results: Twelve (60%) and eight (40%) patients had stage 2 and 3 disease, respectively. Good, intermediate, and poor prognoses were ten, six, and four patients, respectively. Eight patients (40%) were aged above 30 years at detection of testicular; cancer, and seven patients (35%) had pulmonary metastases. Sixteen patients had mixed germ cell tumors (MGCTs) only, Four were unfavorable histology (two MGCTs with choriocarcinoma-predominant, one pure choriocarcinoma and MGCTs with embryonal rhabdomyosarcoma transformation). Thirteen patients (65%) showed no evidence of disease (NED), and 7 patients (35%) that did not survive post therapy. Pulmonary metastases (P = 0.02), unfavorable histology (P = 0.007) were found to be prognostic factors of NED in patients with metastatic testicular NSGCTs. Age (P = 0.06) and stage (P = 0.06) showed considerable trend of significance. But risk group of IGCCCG exhibited no significant difference (P = 1). Conclusion: The presence of pulmonary metastases, and unfavorable histology but not GCCCG classification were associated with poor prognosis in in patients with metastatic testicular NSGCTs. Prognostic reclassification for IGCCCG groups is suggested from our study. Keywords: Testis, Non-seminomatous germ cell tumor, Age, Pulmonary metastasis, Prognostic factors, No evidence of disease |
| first_indexed | 2024-12-11T10:02:57Z |
| format | Article |
| id | doaj.art-fa66c1e7b8c8402cbf0d1a7e66c9e2c3 |
| institution | Directory Open Access Journal |
| issn | 2311-3006 |
| language | English |
| last_indexed | 2024-12-11T10:02:57Z |
| publishDate | 2018-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cancer Research and Practice |
| spelling | doaj.art-fa66c1e7b8c8402cbf0d1a7e66c9e2c32022-12-22T01:12:03ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062018-09-015399104Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapyTzu-Yao Liao0Chuang-Chi Liaw1Cheng-Keng Chuang2Ying-Hsu Chang3Cheng-Lung Hsu4Meng-Ting Peng5John Wen-Cheng Chang6Division of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, TaiwanDivision of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, Taiwan; Corresponding author. Division of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital, 5, Fusing St., Gueishan Township, Taoyuan County, 333, Taiwan.Department of Urology, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, TaiwanDepartment of Urology, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, TaiwanDivision of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, TaiwanDivision of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, TaiwanDivision of Hemato-Oncology, Department of Internal Medicine, Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Taoyuan, TaiwanBackground: We evaluated the prognostic factors of metastatic testicular non-seminomatous germ cell tumor (NSGCT) after chemotherapy. Materials and methods: Data from 20 metastatic testicular NSGCT patients were retrospectively collected between January 2002 and December 2015. The evaluation of prognostic factors included age, pulmonary metastasis, cancer stage, International Germ Cell Cancer Collaborative Group (IGCCCG) classification, and histology. Results: Twelve (60%) and eight (40%) patients had stage 2 and 3 disease, respectively. Good, intermediate, and poor prognoses were ten, six, and four patients, respectively. Eight patients (40%) were aged above 30 years at detection of testicular; cancer, and seven patients (35%) had pulmonary metastases. Sixteen patients had mixed germ cell tumors (MGCTs) only, Four were unfavorable histology (two MGCTs with choriocarcinoma-predominant, one pure choriocarcinoma and MGCTs with embryonal rhabdomyosarcoma transformation). Thirteen patients (65%) showed no evidence of disease (NED), and 7 patients (35%) that did not survive post therapy. Pulmonary metastases (P = 0.02), unfavorable histology (P = 0.007) were found to be prognostic factors of NED in patients with metastatic testicular NSGCTs. Age (P = 0.06) and stage (P = 0.06) showed considerable trend of significance. But risk group of IGCCCG exhibited no significant difference (P = 1). Conclusion: The presence of pulmonary metastases, and unfavorable histology but not GCCCG classification were associated with poor prognosis in in patients with metastatic testicular NSGCTs. Prognostic reclassification for IGCCCG groups is suggested from our study. Keywords: Testis, Non-seminomatous germ cell tumor, Age, Pulmonary metastasis, Prognostic factors, No evidence of diseasehttp://www.sciencedirect.com/science/article/pii/S2311300617301519 |
| spellingShingle | Tzu-Yao Liao Chuang-Chi Liaw Cheng-Keng Chuang Ying-Hsu Chang Cheng-Lung Hsu Meng-Ting Peng John Wen-Cheng Chang Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy Journal of Cancer Research and Practice |
| title | Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy |
| title_full | Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy |
| title_fullStr | Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy |
| title_full_unstemmed | Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy |
| title_short | Prognostic factors of metastatic testicular non-seminomatous germ cell tumors after chemotherapy |
| title_sort | prognostic factors of metastatic testicular non seminomatous germ cell tumors after chemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2311300617301519 |
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