Redox Control of the Dormant Cancer Cell Life Cycle
Following efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no, or only slow, proliferation. Recent advances in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2707 |
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| author | Bowen Li Yichun Huang Hui Ming Edouard C. Nice Rongrong Xuan Canhua Huang |
| author_facet | Bowen Li Yichun Huang Hui Ming Edouard C. Nice Rongrong Xuan Canhua Huang |
| author_sort | Bowen Li |
| collection | DOAJ |
| description | Following efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no, or only slow, proliferation. Recent advances indicate that redox mechanisms control the dormant cancer cell life cycle, including dormancy entrance, long-term dormancy, and metastatic relapse. This regulatory network is orchestrated mainly through redox modification on key regulators or global change of reactive oxygen species (ROS) levels in dormant cancer cells. Encouragingly, several strategies targeting redox signaling, including sleeping, awaking, or killing dormant cancer cells are currently under early clinical evaluation. However, the molecular mechanisms underlying redox control of the dormant cancer cell cycle are poorly understood and need further exploration. In this review, we discuss the underlying molecular basis of redox signaling in the cell life cycle of dormant cancer and the potential redox-based targeting strategies for eliminating dormant cancer cells. |
| first_indexed | 2024-03-10T06:40:03Z |
| format | Article |
| id | doaj.art-fa675bdb417549fd91e6601c4a24f3ad |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:40:03Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fa675bdb417549fd91e6601c4a24f3ad2023-11-22T17:47:51ZengMDPI AGCells2073-44092021-10-011010270710.3390/cells10102707Redox Control of the Dormant Cancer Cell Life CycleBowen Li0Yichun Huang1Hui Ming2Edouard C. Nice3Rongrong Xuan4Canhua Huang5The Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, ChinaClinical Medical College, Hubei University of Science and Technology, Xianning 437000, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, ChinaDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, AustraliaThe Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, ChinaThe Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, ChinaFollowing efficient tumor therapy, some cancer cells may survive through a dormancy process, contributing to tumor recurrence and worse outcomes. Dormancy is considered a process where most cancer cells in a tumor cell population are quiescent with no, or only slow, proliferation. Recent advances indicate that redox mechanisms control the dormant cancer cell life cycle, including dormancy entrance, long-term dormancy, and metastatic relapse. This regulatory network is orchestrated mainly through redox modification on key regulators or global change of reactive oxygen species (ROS) levels in dormant cancer cells. Encouragingly, several strategies targeting redox signaling, including sleeping, awaking, or killing dormant cancer cells are currently under early clinical evaluation. However, the molecular mechanisms underlying redox control of the dormant cancer cell cycle are poorly understood and need further exploration. In this review, we discuss the underlying molecular basis of redox signaling in the cell life cycle of dormant cancer and the potential redox-based targeting strategies for eliminating dormant cancer cells.https://www.mdpi.com/2073-4409/10/10/2707cancer dormancyredox signalingcancer therapyROS |
| spellingShingle | Bowen Li Yichun Huang Hui Ming Edouard C. Nice Rongrong Xuan Canhua Huang Redox Control of the Dormant Cancer Cell Life Cycle Cells cancer dormancy redox signaling cancer therapy ROS |
| title | Redox Control of the Dormant Cancer Cell Life Cycle |
| title_full | Redox Control of the Dormant Cancer Cell Life Cycle |
| title_fullStr | Redox Control of the Dormant Cancer Cell Life Cycle |
| title_full_unstemmed | Redox Control of the Dormant Cancer Cell Life Cycle |
| title_short | Redox Control of the Dormant Cancer Cell Life Cycle |
| title_sort | redox control of the dormant cancer cell life cycle |
| topic | cancer dormancy redox signaling cancer therapy ROS |
| url | https://www.mdpi.com/2073-4409/10/10/2707 |
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