The Impact of Oxidative Stress on Pediatrics Syndromes
Oxidative stress is a condition determined by an imbalance between antioxidant and oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed, it causes both necrosis and cell apoptosis, determining cellular aging, increased carcinogenesis, vascular stiffening, increas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/10/1983 |
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| author | Ginevra Micangeli Michela Menghi Giovanni Profeta Francesca Tarani Alessandro Mariani Carla Petrella Christian Barbato Giampiero Ferraguti Mauro Ceccanti Luigi Tarani Marco Fiore |
| author_facet | Ginevra Micangeli Michela Menghi Giovanni Profeta Francesca Tarani Alessandro Mariani Carla Petrella Christian Barbato Giampiero Ferraguti Mauro Ceccanti Luigi Tarani Marco Fiore |
| author_sort | Ginevra Micangeli |
| collection | DOAJ |
| description | Oxidative stress is a condition determined by an imbalance between antioxidant and oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed, it causes both necrosis and cell apoptosis, determining cellular aging, increased carcinogenesis, vascular stiffening, increased autoimmune diseases, and muscle decay. In the context of pediatric syndromes, oxidative stress could play a role in the first order. In fact, our review of the literature showed that in some pathologies, such as fetal alcohol spectrum disorders, oxidative stress related to the intake of ethanol during pregnancy is a main etiological factor determining the associated clinical syndrome. On the contrary, in Williams syndrome, Down syndrome, Marfan syndrome, Gaucher syndrome, ataxia-telangiectasia, autistic spectrum disorder, Fanconi’s anemia, and primitive immunodeficiencies, the increase in oxidative stress is directly associated with the genetic alterations that cause the same pathologies. Although further studies are needed to better understand the relationship between oxidative stress and pediatric diseases, a better knowledge of this crucial issue encourages future therapeutic strategies. |
| first_indexed | 2024-03-09T20:49:08Z |
| format | Article |
| id | doaj.art-fa6762fdddcf45b3a0061a433d0bdee5 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:49:08Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-fa6762fdddcf45b3a0061a433d0bdee52023-11-23T22:38:52ZengMDPI AGAntioxidants2076-39212022-10-011110198310.3390/antiox11101983The Impact of Oxidative Stress on Pediatrics SyndromesGinevra Micangeli0Michela Menghi1Giovanni Profeta2Francesca Tarani3Alessandro Mariani4Carla Petrella5Christian Barbato6Giampiero Ferraguti7Mauro Ceccanti8Luigi Tarani9Marco Fiore10Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Internal, Anesthesiologic and Cardiovascular Clinical Sciences, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Biochemistry and Cell Biology, IBBC—CNR, 000185 Rome, ItalyInstitute of Biochemistry and Cell Biology, IBBC—CNR, 000185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalySITAC, Società Italiana per il Trattamento dell’Alcolismo, 00184 Rome, ItalyDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Biochemistry and Cell Biology, IBBC—CNR, 000185 Rome, ItalyOxidative stress is a condition determined by an imbalance between antioxidant and oxidative factors. Oxidative stress can have serious consequences on our organism. Indeed, it causes both necrosis and cell apoptosis, determining cellular aging, increased carcinogenesis, vascular stiffening, increased autoimmune diseases, and muscle decay. In the context of pediatric syndromes, oxidative stress could play a role in the first order. In fact, our review of the literature showed that in some pathologies, such as fetal alcohol spectrum disorders, oxidative stress related to the intake of ethanol during pregnancy is a main etiological factor determining the associated clinical syndrome. On the contrary, in Williams syndrome, Down syndrome, Marfan syndrome, Gaucher syndrome, ataxia-telangiectasia, autistic spectrum disorder, Fanconi’s anemia, and primitive immunodeficiencies, the increase in oxidative stress is directly associated with the genetic alterations that cause the same pathologies. Although further studies are needed to better understand the relationship between oxidative stress and pediatric diseases, a better knowledge of this crucial issue encourages future therapeutic strategies.https://www.mdpi.com/2076-3921/11/10/1983oxidative stressantioxidantpediatricsFASDgenetic syndrome |
| spellingShingle | Ginevra Micangeli Michela Menghi Giovanni Profeta Francesca Tarani Alessandro Mariani Carla Petrella Christian Barbato Giampiero Ferraguti Mauro Ceccanti Luigi Tarani Marco Fiore The Impact of Oxidative Stress on Pediatrics Syndromes Antioxidants oxidative stress antioxidant pediatrics FASD genetic syndrome |
| title | The Impact of Oxidative Stress on Pediatrics Syndromes |
| title_full | The Impact of Oxidative Stress on Pediatrics Syndromes |
| title_fullStr | The Impact of Oxidative Stress on Pediatrics Syndromes |
| title_full_unstemmed | The Impact of Oxidative Stress on Pediatrics Syndromes |
| title_short | The Impact of Oxidative Stress on Pediatrics Syndromes |
| title_sort | impact of oxidative stress on pediatrics syndromes |
| topic | oxidative stress antioxidant pediatrics FASD genetic syndrome |
| url | https://www.mdpi.com/2076-3921/11/10/1983 |
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