Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker
Objective To measure plasma levels of malondialdehyde (MDA), a marker of oxidative stress (OS), in patients with major depressive disorder (MDD) compared with healthy control (HC) subjects in order to determine if it is a possible biomarker of depression. Methods This prospective cross-sectional stu...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221094995 |
| _version_ | 1828810058681548800 |
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| author | Miguel A Alvarez-Mon Miguel A Ortega Cielo García-Montero Oscar Fraile-Martinez Guillermo Lahera Jorge Monserrat Ana M Gomez-Lahoz Patricio Molero Luis Gutierrez-Rojas Roberto Rodriguez-Jimenez Javier Quintero Melchor Alvarez-Mon |
| author_facet | Miguel A Alvarez-Mon Miguel A Ortega Cielo García-Montero Oscar Fraile-Martinez Guillermo Lahera Jorge Monserrat Ana M Gomez-Lahoz Patricio Molero Luis Gutierrez-Rojas Roberto Rodriguez-Jimenez Javier Quintero Melchor Alvarez-Mon |
| author_sort | Miguel A Alvarez-Mon |
| collection | DOAJ |
| description | Objective To measure plasma levels of malondialdehyde (MDA), a marker of oxidative stress (OS), in patients with major depressive disorder (MDD) compared with healthy control (HC) subjects in order to determine if it is a possible biomarker of depression. Methods This prospective cross-sectional study enrolled patients with MDD and HC subjects. The plasma levels of MDA were measured using a commercially-available colorimetric assay. Results A total of 30 patients with MDD and 20 HC subjects with similar sex, age and body mass index distribution were enrolled in the study. Patients with MDD had significantly higher plasma levels of MDA than the HC subjects. Receiver operating characteristic curve analysis for plasma MDA levels in patients with MDD demonstrated an area under the curve of 0.9767. Conclusion The findings of this current study provide further evidence of the role pathophysiological relevance of OS and MDA in MDD. This study provides the basis for the use of MDA as a biomarker for MDD. |
| first_indexed | 2024-12-12T09:05:08Z |
| format | Article |
| id | doaj.art-fa6885d6ce9b413c8aded4b5a17ba4aa |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-12T09:05:08Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-fa6885d6ce9b413c8aded4b5a17ba4aa2022-12-22T00:29:41ZengSAGE PublishingJournal of International Medical Research1473-23002022-05-015010.1177/03000605221094995Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarkerMiguel A Alvarez-MonMiguel A OrtegaCielo García-MonteroOscar Fraile-MartinezGuillermo LaheraJorge MonserratAna M Gomez-LahozPatricio MoleroLuis Gutierrez-RojasRoberto Rodriguez-JimenezJavier QuinteroMelchor Alvarez-MonObjective To measure plasma levels of malondialdehyde (MDA), a marker of oxidative stress (OS), in patients with major depressive disorder (MDD) compared with healthy control (HC) subjects in order to determine if it is a possible biomarker of depression. Methods This prospective cross-sectional study enrolled patients with MDD and HC subjects. The plasma levels of MDA were measured using a commercially-available colorimetric assay. Results A total of 30 patients with MDD and 20 HC subjects with similar sex, age and body mass index distribution were enrolled in the study. Patients with MDD had significantly higher plasma levels of MDA than the HC subjects. Receiver operating characteristic curve analysis for plasma MDA levels in patients with MDD demonstrated an area under the curve of 0.9767. Conclusion The findings of this current study provide further evidence of the role pathophysiological relevance of OS and MDA in MDD. This study provides the basis for the use of MDA as a biomarker for MDD.https://doi.org/10.1177/03000605221094995 |
| spellingShingle | Miguel A Alvarez-Mon Miguel A Ortega Cielo García-Montero Oscar Fraile-Martinez Guillermo Lahera Jorge Monserrat Ana M Gomez-Lahoz Patricio Molero Luis Gutierrez-Rojas Roberto Rodriguez-Jimenez Javier Quintero Melchor Alvarez-Mon Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker Journal of International Medical Research |
| title | Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker |
| title_full | Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker |
| title_fullStr | Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker |
| title_full_unstemmed | Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker |
| title_short | Differential malondialdehyde (MDA) detection in plasma samples of patients with major depressive disorder (MDD): A potential biomarker |
| title_sort | differential malondialdehyde mda detection in plasma samples of patients with major depressive disorder mdd a potential biomarker |
| url | https://doi.org/10.1177/03000605221094995 |
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