Modeling the Effect of Spatial Structure on Solid Tumor Evolution and Circulating Tumor DNA Composition

Modeling the Effect of Spatial Structure on Solid Tumor Evolution and Circulating Tumor DNA Composition

Circulating tumor DNA (ctDNA) monitoring, while sufficiently advanced to reflect tumor evolution in real time and inform cancer diagnosis, treatment, and prognosis, mainly relies on DNA that originates from cell death via apoptosis or necrosis. In solid tumors, chemotherapy and immune infiltration c...

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Bibliographic Details
Main Authors: Thomas Rachman, David Bartlett, William LaFramboise, Patrick Wagner, Russell Schwartz, Oana Carja
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
tumor growth model
tumor evolution
spatial evolution
ctDNA
tumor DNA shedding
Online Access:https://www.mdpi.com/2072-6694/16/5/844

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