A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical Applications
Over recent years, nosocomial infections, and the morbidity and mortality associated with pathogenic bacteria have dramatically increased due to antibiotic resistance and imposed significant burdens on the global health system. Critical shortage of effective therapeutics against multidrug-resistant...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-07-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-14341-en.html |
| _version_ | 1797944941811335168 |
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| author | Yaser Delbari Yaser Mohassel Yadollah Bahrami Elham Kakaie Ali Mostafaie |
| author_facet | Yaser Delbari Yaser Mohassel Yadollah Bahrami Elham Kakaie Ali Mostafaie |
| author_sort | Yaser Delbari |
| collection | DOAJ |
| description | Over recent years, nosocomial infections, and the morbidity and mortality associated with pathogenic bacteria have dramatically increased due to antibiotic resistance and imposed significant burdens on the global health system. Critical shortage of effective therapeutics against multidrug-resistant bacteria highlights the need for development of novel antibiotics. Actinobacteria are well-known sources of natural bioactive compounds, especially antibiotics. Nearly two-thirds of the antibiotics on the market have actinobacterial origins. Endophytic actinobacteria residing within plants contribute to the plant growth and survival by producing plethora of secondary metabolites. Therefore, isolation, cultivation, and identification of new strains, as well as their potential to produce antimicrobial compounds, are of great importance. Lack of published research in this field highlights the importance of this review in Iran. The aim of this review was to present the latest methods for the isolation and identification of endophytic actinobacteria and introducing relevant databases. We also studied the most recent isolated strains, chemical structure of 51 newly identified secondary metabolites, and their potential medical-pharmaceutical applications. This study revealed that endophytic actinobacteria are prolific sources of bioactive secondary metabolites with high levels of structural diversity and potent pharmaceutical and medicinal applications. |
| first_indexed | 2024-04-10T20:47:34Z |
| format | Article |
| id | doaj.art-fa6a2f127a8845708e80b739ba066ea0 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:47:34Z |
| publishDate | 2020-07-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-fa6a2f127a8845708e80b739ba066ea02023-01-24T06:49:19ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792020-07-0130186195217A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical ApplicationsYaser Delbari0Yaser Mohassel1Yadollah Bahrami2Elham Kakaie3Ali Mostafaie4 MSc in Medical Biotechnology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran MSc in Medical Biochemistry, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Assistant Professor, Department of Medical Biotechnology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Department of Medical Biotechnology, School of Medicine, College of Medicine and Public Health, Flinders University, Adelaide, Australia Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran BSc in Nursing, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Professor, Medical Biology Research Center, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Over recent years, nosocomial infections, and the morbidity and mortality associated with pathogenic bacteria have dramatically increased due to antibiotic resistance and imposed significant burdens on the global health system. Critical shortage of effective therapeutics against multidrug-resistant bacteria highlights the need for development of novel antibiotics. Actinobacteria are well-known sources of natural bioactive compounds, especially antibiotics. Nearly two-thirds of the antibiotics on the market have actinobacterial origins. Endophytic actinobacteria residing within plants contribute to the plant growth and survival by producing plethora of secondary metabolites. Therefore, isolation, cultivation, and identification of new strains, as well as their potential to produce antimicrobial compounds, are of great importance. Lack of published research in this field highlights the importance of this review in Iran. The aim of this review was to present the latest methods for the isolation and identification of endophytic actinobacteria and introducing relevant databases. We also studied the most recent isolated strains, chemical structure of 51 newly identified secondary metabolites, and their potential medical-pharmaceutical applications. This study revealed that endophytic actinobacteria are prolific sources of bioactive secondary metabolites with high levels of structural diversity and potent pharmaceutical and medicinal applications.http://jmums.mazums.ac.ir/article-1-14341-en.htmlactinobacteriaendophytesbioactive compoundsdrug resistancenosocomial infectionshospital infections |
| spellingShingle | Yaser Delbari Yaser Mohassel Yadollah Bahrami Elham Kakaie Ali Mostafaie A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical Applications Journal of Mazandaran University of Medical Sciences actinobacteria endophytes bioactive compounds drug resistance nosocomial infections hospital infections |
| title | A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical Applications |
| title_full | A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical Applications |
| title_fullStr | A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical Applications |
| title_full_unstemmed | A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical Applications |
| title_short | A Review on Isolation and Identification of Endophytic Actinobacteria, Their Chemical Structure, Bioactive Compounds, and Potential Medical-Pharmaceutical Applications |
| title_sort | review on isolation and identification of endophytic actinobacteria their chemical structure bioactive compounds and potential medical pharmaceutical applications |
| topic | actinobacteria endophytes bioactive compounds drug resistance nosocomial infections hospital infections |
| url | http://jmums.mazums.ac.ir/article-1-14341-en.html |
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