Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities
Articular cartilage (AC), which covers the ends of bones in joints, particularly the knee joints, provides a robust interface to maintain frictionless movement during daily life due to its remarkable lubricating and load-bearing capacities. However, osteoarthritis (OA), characterized by the progress...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/2/144 |
| _version_ | 1797620922047266816 |
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| author | Fei Qiu Xiaopeng Fan Wen Chen Chunming Xu Yumei Li Renjian Xie |
| author_facet | Fei Qiu Xiaopeng Fan Wen Chen Chunming Xu Yumei Li Renjian Xie |
| author_sort | Fei Qiu |
| collection | DOAJ |
| description | Articular cartilage (AC), which covers the ends of bones in joints, particularly the knee joints, provides a robust interface to maintain frictionless movement during daily life due to its remarkable lubricating and load-bearing capacities. However, osteoarthritis (OA), characterized by the progressive degradation of AC, compromises the properties of AC and thus leads to frayed and rough interfaces between the bones, which subsequently accelerates the progression of OA. Hydrogels, composed of highly hydrated and interconnected polymer chains, are potential candidates for AC replacement due to their physical and chemical properties being similar to those of AC. In this review, we summarize the recent progress of hydrogel-based synthetic cartilage, or cartilage-like hydrogels, with a particular focus on their lubrication and load-bearing properties. The different formulations, current limitations, and challenges of such hydrogels are also discussed. Moreover, we discuss the future directions of hydrogel-based synthetic cartilage to repair and even regenerate the damaged AC. |
| first_indexed | 2024-03-11T08:48:26Z |
| format | Article |
| id | doaj.art-fa6ac8af58e148afa81840d122879b1e |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T08:48:26Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-fa6ac8af58e148afa81840d122879b1e2023-11-16T20:39:49ZengMDPI AGGels2310-28612023-02-019214410.3390/gels9020144Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing CapacitiesFei Qiu0Xiaopeng Fan1Wen Chen2Chunming Xu3Yumei Li4Renjian Xie5Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, ChinaKey Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, ChinaArticular cartilage (AC), which covers the ends of bones in joints, particularly the knee joints, provides a robust interface to maintain frictionless movement during daily life due to its remarkable lubricating and load-bearing capacities. However, osteoarthritis (OA), characterized by the progressive degradation of AC, compromises the properties of AC and thus leads to frayed and rough interfaces between the bones, which subsequently accelerates the progression of OA. Hydrogels, composed of highly hydrated and interconnected polymer chains, are potential candidates for AC replacement due to their physical and chemical properties being similar to those of AC. In this review, we summarize the recent progress of hydrogel-based synthetic cartilage, or cartilage-like hydrogels, with a particular focus on their lubrication and load-bearing properties. The different formulations, current limitations, and challenges of such hydrogels are also discussed. Moreover, we discuss the future directions of hydrogel-based synthetic cartilage to repair and even regenerate the damaged AC.https://www.mdpi.com/2310-2861/9/2/144articular cartilagehydrogelsimplantslubricationload-bearing |
| spellingShingle | Fei Qiu Xiaopeng Fan Wen Chen Chunming Xu Yumei Li Renjian Xie Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities Gels articular cartilage hydrogels implants lubrication load-bearing |
| title | Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities |
| title_full | Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities |
| title_fullStr | Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities |
| title_full_unstemmed | Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities |
| title_short | Recent Progress in Hydrogel-Based Synthetic Cartilage: Focus on Lubrication and Load-Bearing Capacities |
| title_sort | recent progress in hydrogel based synthetic cartilage focus on lubrication and load bearing capacities |
| topic | articular cartilage hydrogels implants lubrication load-bearing |
| url | https://www.mdpi.com/2310-2861/9/2/144 |
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