Mycotoxin binders potential on histological of ovary mice exposed by zearalenone
Aim: This study was conducted to examine the potential of mycotoxin binder in ceasing zearalenone (ZEN) effect on mice reproduction. ZEN mycotoxin can induce reactive oxygen species that may cause damage and cell death. ZEN is estrogenic so that it may affect the reproductive organs failure. Mate...
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| Format: | Article |
| Language: | English |
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Veterinary World
2017-03-01
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| Series: | Veterinary World |
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| Online Access: | http://www.veterinaryworld.org/Vol.10/March-2017/14.pdf |
| _version_ | 1831545745112563712 |
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| author | Abdul Samik Erma Safitri |
| author_facet | Abdul Samik Erma Safitri |
| author_sort | Abdul Samik |
| collection | DOAJ |
| description | Aim: This study was conducted to examine the potential of mycotoxin binder in ceasing zearalenone (ZEN) effect on mice reproduction. ZEN mycotoxin can induce reactive oxygen species that may cause damage and cell death. ZEN is estrogenic so that it may affect the reproductive organs failure.
Materials and Methods: Mycotoxin binder administration to female mice exposed to ZEN was aimed to count the number of primary follicles, secondary follicles, tertiary follicles, de Graaf's follicles, and the corpus luteum (CL). Negative control group (C) was not exposed to ZEN and without the administration of mycotoxin binders, while positive control group (C+) was exposed to 0.1 mg/mouse/day ZEN and without the provision of mycotoxin binders. Treatment groups (T1, T2, T3) were exposed to 0.1 mg/mouse/day ZEN and mycotoxin binders 0.5; 1; 2 mg/BW/day.
Results: ZEN and mycotoxin binders administration was conducted for 10 days. The number of primary follicles, secondary, tertiary, de Graaf's follicles and CL in negative control (C-) was 14.2±1.36, 11.2±0.28, 6.5±0.53, 7.5±0.74, and 2.3±0.35. The number in positive control (C+) group was as follows 7.1±0.12, 3.7±1.17, 3.8±1.21, 1.5±0.62, and 2.3±0.34. Results in treatment 1 (T1) were as follows 6.2±0.16, 5.2±0.16, 3.6±0.16, 2.6±0.19, and 2.6±0.10; in treatment 2 (T2) 7.8±0.28, 5.8±0.53, 3.7±0.26, 2.7±0.26, and 2.5±0.10; and in treatment 3 (T3) 8.4±0.34, 8.4±0.34, 4.6±0.34, 4.5±1.01, and 3.4±0.23.
Conclusion: The number of follicles and CL more in line with increasing doses of mycotoxin binders. Required more than 2 mg/mouse/day mycotoxin binders to inhibit the effects of ZEN so that its can maintain the number of primary follicle, secondary follicle, tertiary follicle, the de Graaf's follicle, and the number of CL in the ovary of ZEN-exposed female mice (Mus musculus). |
| first_indexed | 2024-12-17T01:32:54Z |
| format | Article |
| id | doaj.art-fa6b6d0e8bee48eab9f8592f3da8508c |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-17T01:32:54Z |
| publishDate | 2017-03-01 |
| publisher | Veterinary World |
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| series | Veterinary World |
| spelling | doaj.art-fa6b6d0e8bee48eab9f8592f3da8508c2022-12-21T22:08:31ZengVeterinary WorldVeterinary World0972-89882231-09162017-03-0110335335710.14202/vetworld.2017.353-357Mycotoxin binders potential on histological of ovary mice exposed by zearalenoneAbdul Samik0Erma Safitri1Department of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia.Department of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Indonesia; Stem Cells Research Division of Institute Tropical Disease, Universitas Airlangga, Indonesia.Aim: This study was conducted to examine the potential of mycotoxin binder in ceasing zearalenone (ZEN) effect on mice reproduction. ZEN mycotoxin can induce reactive oxygen species that may cause damage and cell death. ZEN is estrogenic so that it may affect the reproductive organs failure. Materials and Methods: Mycotoxin binder administration to female mice exposed to ZEN was aimed to count the number of primary follicles, secondary follicles, tertiary follicles, de Graaf's follicles, and the corpus luteum (CL). Negative control group (C) was not exposed to ZEN and without the administration of mycotoxin binders, while positive control group (C+) was exposed to 0.1 mg/mouse/day ZEN and without the provision of mycotoxin binders. Treatment groups (T1, T2, T3) were exposed to 0.1 mg/mouse/day ZEN and mycotoxin binders 0.5; 1; 2 mg/BW/day. Results: ZEN and mycotoxin binders administration was conducted for 10 days. The number of primary follicles, secondary, tertiary, de Graaf's follicles and CL in negative control (C-) was 14.2±1.36, 11.2±0.28, 6.5±0.53, 7.5±0.74, and 2.3±0.35. The number in positive control (C+) group was as follows 7.1±0.12, 3.7±1.17, 3.8±1.21, 1.5±0.62, and 2.3±0.34. Results in treatment 1 (T1) were as follows 6.2±0.16, 5.2±0.16, 3.6±0.16, 2.6±0.19, and 2.6±0.10; in treatment 2 (T2) 7.8±0.28, 5.8±0.53, 3.7±0.26, 2.7±0.26, and 2.5±0.10; and in treatment 3 (T3) 8.4±0.34, 8.4±0.34, 4.6±0.34, 4.5±1.01, and 3.4±0.23. Conclusion: The number of follicles and CL more in line with increasing doses of mycotoxin binders. Required more than 2 mg/mouse/day mycotoxin binders to inhibit the effects of ZEN so that its can maintain the number of primary follicle, secondary follicle, tertiary follicle, the de Graaf's follicle, and the number of CL in the ovary of ZEN-exposed female mice (Mus musculus).http://www.veterinaryworld.org/Vol.10/March-2017/14.pdfcorpus luteumfolliclesmycotoxin binderszearalenone |
| spellingShingle | Abdul Samik Erma Safitri Mycotoxin binders potential on histological of ovary mice exposed by zearalenone Veterinary World corpus luteum follicles mycotoxin binders zearalenone |
| title | Mycotoxin binders potential on histological of ovary mice exposed by zearalenone |
| title_full | Mycotoxin binders potential on histological of ovary mice exposed by zearalenone |
| title_fullStr | Mycotoxin binders potential on histological of ovary mice exposed by zearalenone |
| title_full_unstemmed | Mycotoxin binders potential on histological of ovary mice exposed by zearalenone |
| title_short | Mycotoxin binders potential on histological of ovary mice exposed by zearalenone |
| title_sort | mycotoxin binders potential on histological of ovary mice exposed by zearalenone |
| topic | corpus luteum follicles mycotoxin binders zearalenone |
| url | http://www.veterinaryworld.org/Vol.10/March-2017/14.pdf |
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