Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193a
Glomerular parietal epithelial cells (PECs) have been increasingly recognized to have crucial functions. Lineage tracking in animal models showed the expression of a podocyte phenotype by PECs during normal glomerular growth and after acute podocyte injury, suggesting a reparative role of PECs. Conv...
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MDPI AG
2023-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/2/266 |
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| author | Joyita Bharati Praveen N. Chander Pravin C. Singhal |
| author_facet | Joyita Bharati Praveen N. Chander Pravin C. Singhal |
| author_sort | Joyita Bharati |
| collection | DOAJ |
| description | Glomerular parietal epithelial cells (PECs) have been increasingly recognized to have crucial functions. Lineage tracking in animal models showed the expression of a podocyte phenotype by PECs during normal glomerular growth and after acute podocyte injury, suggesting a reparative role of PECs. Conversely, activated PECs are speculated to be pathogenic and comprise extracapillary proliferation in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CrescGN). The reparative and pathogenic roles of PECs seem to represent two sides of PEC behavior directed by the local milieu and mediators. Recent studies suggest microRNA-193a (miR193a) is involved in the pathogenesis of FSGS and CrescGN. In a mouse model of primary FSGS, the induction of miR193a caused the downregulation of Wilms’ tumor protein, leading to the dedifferentiation of podocytes. On the other hand, the inhibition of miR193a resulted in reduced crescent lesions in a mouse model of CrescGN. Interestingly, in vitro studies report that the downregulation of miR193a induces trans-differentiation of PECs into a podocyte phenotype. This narrative review highlights the critical role of PEC behavior in health and during disease and its modulation by miR193a. |
| first_indexed | 2024-03-11T09:06:32Z |
| format | Article |
| id | doaj.art-fa6c77941747409b9a16a122c94bb8f3 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T09:06:32Z |
| publishDate | 2023-01-01 |
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| series | Biomolecules |
| spelling | doaj.art-fa6c77941747409b9a16a122c94bb8f32023-11-16T19:22:43ZengMDPI AGBiomolecules2218-273X2023-01-0113226610.3390/biom13020266Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193aJoyita Bharati0Praveen N. Chander1Pravin C. Singhal2Institute of Molecular Medicine, Feinstein Institute for Medical Research and Department of Medicine, Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY 11549, USANew York Medical College, Touro College and University System Valhalla, Valhalla, NY 10595, USAInstitute of Molecular Medicine, Feinstein Institute for Medical Research and Department of Medicine, Zucker School of Medicine at Hofstra-Northwell, Hempstead, NY 11549, USAGlomerular parietal epithelial cells (PECs) have been increasingly recognized to have crucial functions. Lineage tracking in animal models showed the expression of a podocyte phenotype by PECs during normal glomerular growth and after acute podocyte injury, suggesting a reparative role of PECs. Conversely, activated PECs are speculated to be pathogenic and comprise extracapillary proliferation in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CrescGN). The reparative and pathogenic roles of PECs seem to represent two sides of PEC behavior directed by the local milieu and mediators. Recent studies suggest microRNA-193a (miR193a) is involved in the pathogenesis of FSGS and CrescGN. In a mouse model of primary FSGS, the induction of miR193a caused the downregulation of Wilms’ tumor protein, leading to the dedifferentiation of podocytes. On the other hand, the inhibition of miR193a resulted in reduced crescent lesions in a mouse model of CrescGN. Interestingly, in vitro studies report that the downregulation of miR193a induces trans-differentiation of PECs into a podocyte phenotype. This narrative review highlights the critical role of PEC behavior in health and during disease and its modulation by miR193a.https://www.mdpi.com/2218-273X/13/2/266parietal epithelial cellpodocytemicro-RNAFSGScrescentic glomerulonephritis |
| spellingShingle | Joyita Bharati Praveen N. Chander Pravin C. Singhal Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193a Biomolecules parietal epithelial cell podocyte micro-RNA FSGS crescentic glomerulonephritis |
| title | Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193a |
| title_full | Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193a |
| title_fullStr | Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193a |
| title_full_unstemmed | Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193a |
| title_short | Parietal Epithelial Cell Behavior and Its Modulation by microRNA-193a |
| title_sort | parietal epithelial cell behavior and its modulation by microrna 193a |
| topic | parietal epithelial cell podocyte micro-RNA FSGS crescentic glomerulonephritis |
| url | https://www.mdpi.com/2218-273X/13/2/266 |
| work_keys_str_mv | AT joyitabharati parietalepithelialcellbehavioranditsmodulationbymicrorna193a AT praveennchander parietalepithelialcellbehavioranditsmodulationbymicrorna193a AT pravincsinghal parietalepithelialcellbehavioranditsmodulationbymicrorna193a |