Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model
Amr Awara,1 Ayman Atiba,2 Duaa Helal,3 Hazem Elbedewy1 1Ophthalmology Department, Tanta University, Tanta, Egypt; 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; 3Pathology Department, Tanta University, Tanta, EgyptC...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-02-01
|
| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/effectiveness-of-subconjunctival-cyclosporine-in-treatment-of-acute-al-peer-reviewed-article-OPTH |
| _version_ | 1831583049085616128 |
|---|---|
| author | Awara A Atiba A Helal D Elbedewy H |
| author_facet | Awara A Atiba A Helal D Elbedewy H |
| author_sort | Awara A |
| collection | DOAJ |
| description | Amr Awara,1 Ayman Atiba,2 Duaa Helal,3 Hazem Elbedewy1 1Ophthalmology Department, Tanta University, Tanta, Egypt; 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; 3Pathology Department, Tanta University, Tanta, EgyptCorrespondence: Amr AwaraOphthalmology Department, Tanta University, Tanta 31511, EgyptTel +2-01274005384Fax +20403415008Email amrawara@gmail.comBackground: Eye allergy is widely spread worldwide. The treatment includes topical anti-histamines, steroids and non-steroidal drugs. Steroids are the first choice by many ophthalmologists, but unfortunately they may cause serious side effects. Cyclosporine A (CsA) is an immunomodulator drug that can improve eye allergy and reduce the need for steroids; however, topical preparation of CsA is difficult because of the lipophilic nature of the drug.Methods: An experimental study included 16 rats with induced allergy were divided into 2 groups. Group 1: allergic non-treated (6 rats), and Group 2: allergic treated with 0.5 mL subconjunctival CsA 1% (10 rats). Half of each group was sacrificed at 24 hrs and the other half at 1 week. Conjunctival hyperemia and eosinophilic cell count were assessed at each time.Results: Group 2 (CsA treated) showed significantly lower hyperemia score and eosinophilic count at both 24 hrs and 1 week. No ocular complications were noted.Conclusion: Subconjunctival CsA was safe and effective in treating ocular allergy through improving conjunctival hyperemia and reducing eosinophilic cell count with no significant ocular side effects.Keywords: eye allergy, cyclosporine A, eosinophilia, subconjunctival |
| first_indexed | 2024-12-17T20:35:22Z |
| format | Article |
| id | doaj.art-fa6e2818571b477594e2efe420b93a97 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-17T20:35:22Z |
| publishDate | 2020-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-fa6e2818571b477594e2efe420b93a972022-12-21T21:33:28ZengDove Medical PressClinical Ophthalmology1177-54832020-02-01Volume 1443143551798Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-ModelAwara AAtiba AHelal DElbedewy HAmr Awara,1 Ayman Atiba,2 Duaa Helal,3 Hazem Elbedewy1 1Ophthalmology Department, Tanta University, Tanta, Egypt; 2Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt; 3Pathology Department, Tanta University, Tanta, EgyptCorrespondence: Amr AwaraOphthalmology Department, Tanta University, Tanta 31511, EgyptTel +2-01274005384Fax +20403415008Email amrawara@gmail.comBackground: Eye allergy is widely spread worldwide. The treatment includes topical anti-histamines, steroids and non-steroidal drugs. Steroids are the first choice by many ophthalmologists, but unfortunately they may cause serious side effects. Cyclosporine A (CsA) is an immunomodulator drug that can improve eye allergy and reduce the need for steroids; however, topical preparation of CsA is difficult because of the lipophilic nature of the drug.Methods: An experimental study included 16 rats with induced allergy were divided into 2 groups. Group 1: allergic non-treated (6 rats), and Group 2: allergic treated with 0.5 mL subconjunctival CsA 1% (10 rats). Half of each group was sacrificed at 24 hrs and the other half at 1 week. Conjunctival hyperemia and eosinophilic cell count were assessed at each time.Results: Group 2 (CsA treated) showed significantly lower hyperemia score and eosinophilic count at both 24 hrs and 1 week. No ocular complications were noted.Conclusion: Subconjunctival CsA was safe and effective in treating ocular allergy through improving conjunctival hyperemia and reducing eosinophilic cell count with no significant ocular side effects.Keywords: eye allergy, cyclosporine A, eosinophilia, subconjunctivalhttps://www.dovepress.com/effectiveness-of-subconjunctival-cyclosporine-in-treatment-of-acute-al-peer-reviewed-article-OPTHeye allergycyclosporine aeosinophiliasubconjunctival. |
| spellingShingle | Awara A Atiba A Helal D Elbedewy H Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model Clinical Ophthalmology eye allergy cyclosporine a eosinophilia subconjunctival. |
| title | Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model |
| title_full | Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model |
| title_fullStr | Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model |
| title_full_unstemmed | Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model |
| title_short | Effectiveness of Subconjunctival Cyclosporine in Treatment of Acute Allergic Conjunctivitis in a Rat-Model |
| title_sort | effectiveness of subconjunctival cyclosporine in treatment of acute allergic conjunctivitis in a rat model |
| topic | eye allergy cyclosporine a eosinophilia subconjunctival. |
| url | https://www.dovepress.com/effectiveness-of-subconjunctival-cyclosporine-in-treatment-of-acute-al-peer-reviewed-article-OPTH |
| work_keys_str_mv | AT awaraa effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel AT atibaa effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel AT helald effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel AT elbedewyh effectivenessofsubconjunctivalcyclosporineintreatmentofacuteallergicconjunctivitisinaratmodel |