Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma
Classical Hodgkin Lymphoma incidence increases in HIV-1-infected patients (HIV-cHL). HIV infection is associated with higher B-cell activation. Here, in 38 HIV-cHL patients from the French cohort ANRS-CO16 Lymphovir, we examined longitudinally over 24 months the serum levels of the B-cell activating...
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/1/128 |
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| author | Raphael Lievin Houria Hendel-Chavez Aliou Baldé Rémi Lancar Michèle Algarte-Génin Roman Krzysiek Dominique Costagliola Lambert Assoumou Yassine Taoufik Caroline Besson |
| author_facet | Raphael Lievin Houria Hendel-Chavez Aliou Baldé Rémi Lancar Michèle Algarte-Génin Roman Krzysiek Dominique Costagliola Lambert Assoumou Yassine Taoufik Caroline Besson |
| author_sort | Raphael Lievin |
| collection | DOAJ |
| description | Classical Hodgkin Lymphoma incidence increases in HIV-1-infected patients (HIV-cHL). HIV infection is associated with higher B-cell activation. Here, in 38 HIV-cHL patients from the French cohort ANRS-CO16 Lymphovir, we examined longitudinally over 24 months the serum levels of the B-cell activating cytokines IL10, IL6, and BAFF, and blood distribution of B-cell subsets. Fourteen HIV-cHL patients were also compared to matched HIV-infected controls without cHL. IL10, IL6, and BAFF levels were higher in HIV-cHL patients than in controls (<i>p</i> < 0.0001, <i>p</i> = 0.002, and <i>p</i> < 0.0001, respectively). Cytokine levels increased in patients with advanced-stage lymphoma compared to those with limited-stage (<i>p</i> = 0.002, <i>p</i> = 0.03, and <i>p</i> = 0.01, respectively). Cytokine levels significantly decreased following HIV-cHL diagnosis and treatment. Blood counts of whole B-cells were similar in HIV-cHL patients and controls, but the distribution of B-cell subsets was different with higher ratios of naive B-cells over memory B-cells in HIV-cHL patients. Blood accumulation of naive B-cells was more marked in patients with advanced cHL stages (<i>p</i> = 0.06). During the follow-up, total B-cell counts increased (<i>p</i> < 0.0001), and the proportion of naive B-cells increased further (<i>p</i> = 0.04). Together the results suggest that in HIV-infected patients, cHL is associated with a particular B-cell-related environment that includes increased production of B-cell-activating cytokines and altered peripheral distribution of B-cell subsets. This B-cell-related environment may fuel the process of tumorigenesis. |
| first_indexed | 2024-03-10T03:47:53Z |
| format | Article |
| id | doaj.art-fa6f7a3ee84645ddbee636482b6a1968 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:47:53Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fa6f7a3ee84645ddbee636482b6a19682023-11-23T11:16:31ZengMDPI AGCancers2072-66942021-12-0114112810.3390/cancers14010128Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin LymphomaRaphael Lievin0Houria Hendel-Chavez1Aliou Baldé2Rémi Lancar3Michèle Algarte-Génin4Roman Krzysiek5Dominique Costagliola6Lambert Assoumou7Yassine Taoufik8Caroline Besson9Department of Hematology and Oncology, Hospital of Versailles, 78150 Le Chesnay, FranceService d’Hématologie et Immunologie Biologique, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, 94270 Le Kremlin-Bicêtre, FranceInstitut Pierre Louis d’Epidémiologie et de Santé Publique, IPLESP, Sorbonne Université, INSERM UMR-S 1136, 75646 Paris, FranceInstitut Pierre Louis d’Epidémiologie et de Santé Publique, IPLESP, Sorbonne Université, INSERM UMR-S 1136, 75646 Paris, FranceInstitut Pierre Louis d’Epidémiologie et de Santé Publique, IPLESP, Sorbonne Université, INSERM UMR-S 1136, 75646 Paris, FranceService d’Hématologie et Immunologie Biologique, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, 94270 Le Kremlin-Bicêtre, FranceInstitut Pierre Louis d’Epidémiologie et de Santé Publique, IPLESP, Sorbonne Université, INSERM UMR-S 1136, 75646 Paris, FranceInstitut Pierre Louis d’Epidémiologie et de Santé Publique, IPLESP, Sorbonne Université, INSERM UMR-S 1136, 75646 Paris, FranceService d’Hématologie et Immunologie Biologique, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, 94270 Le Kremlin-Bicêtre, FranceDepartment of Hematology and Oncology, Hospital of Versailles, 78150 Le Chesnay, FranceClassical Hodgkin Lymphoma incidence increases in HIV-1-infected patients (HIV-cHL). HIV infection is associated with higher B-cell activation. Here, in 38 HIV-cHL patients from the French cohort ANRS-CO16 Lymphovir, we examined longitudinally over 24 months the serum levels of the B-cell activating cytokines IL10, IL6, and BAFF, and blood distribution of B-cell subsets. Fourteen HIV-cHL patients were also compared to matched HIV-infected controls without cHL. IL10, IL6, and BAFF levels were higher in HIV-cHL patients than in controls (<i>p</i> < 0.0001, <i>p</i> = 0.002, and <i>p</i> < 0.0001, respectively). Cytokine levels increased in patients with advanced-stage lymphoma compared to those with limited-stage (<i>p</i> = 0.002, <i>p</i> = 0.03, and <i>p</i> = 0.01, respectively). Cytokine levels significantly decreased following HIV-cHL diagnosis and treatment. Blood counts of whole B-cells were similar in HIV-cHL patients and controls, but the distribution of B-cell subsets was different with higher ratios of naive B-cells over memory B-cells in HIV-cHL patients. Blood accumulation of naive B-cells was more marked in patients with advanced cHL stages (<i>p</i> = 0.06). During the follow-up, total B-cell counts increased (<i>p</i> < 0.0001), and the proportion of naive B-cells increased further (<i>p</i> = 0.04). Together the results suggest that in HIV-infected patients, cHL is associated with a particular B-cell-related environment that includes increased production of B-cell-activating cytokines and altered peripheral distribution of B-cell subsets. This B-cell-related environment may fuel the process of tumorigenesis.https://www.mdpi.com/2072-6694/14/1/128Hodgkin lymphomaHIVimmunologycytokines |
| spellingShingle | Raphael Lievin Houria Hendel-Chavez Aliou Baldé Rémi Lancar Michèle Algarte-Génin Roman Krzysiek Dominique Costagliola Lambert Assoumou Yassine Taoufik Caroline Besson Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma Cancers Hodgkin lymphoma HIV immunology cytokines |
| title | Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma |
| title_full | Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma |
| title_fullStr | Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma |
| title_full_unstemmed | Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma |
| title_short | Increased Production of B-Cell Activating Cytokines and Altered Peripheral B-Cell Subset Distribution during HIV-Related Classical Hodgkin Lymphoma |
| title_sort | increased production of b cell activating cytokines and altered peripheral b cell subset distribution during hiv related classical hodgkin lymphoma |
| topic | Hodgkin lymphoma HIV immunology cytokines |
| url | https://www.mdpi.com/2072-6694/14/1/128 |
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