[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease
The link between amyloid and tau proteins with Alzheimer’s disease progression remains unclear. Here, the authors propose HDACs I downregulation as an element linking the deleterious effects of brain proteinopathies with disease progression.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30653-5 |
| _version_ | 1818190146544074752 |
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| author | Tharick A. Pascoal Mira Chamoun Elad Lax Hsiao-Ying Wey Monica Shin Kok Pin Ng Min Su Kang Sulantha Mathotaarachchi Andrea L. Benedet Joseph Therriault Firoza Z. Lussier Frederick A. Schroeder Jonathan M. DuBois Baileigh G. Hightower Tonya M. Gilbert Nicole R. Zürcher Changning Wang Robert Hopewell Mallar Chakravarty Melissa Savard Emilie Thomas Sara Mohaddes Sarah Farzin Alyssa Salaciak Stephanie Tullo A. Claudio Cuello Jean-Paul Soucy Gassan Massarweh Heungsun Hwang Eliane Kobayashi Bradley T. Hyman Bradford C. Dickerson Marie-Christine Guiot Moshe Szyf Serge Gauthier Jacob M. Hooker Pedro Rosa-Neto |
| author_facet | Tharick A. Pascoal Mira Chamoun Elad Lax Hsiao-Ying Wey Monica Shin Kok Pin Ng Min Su Kang Sulantha Mathotaarachchi Andrea L. Benedet Joseph Therriault Firoza Z. Lussier Frederick A. Schroeder Jonathan M. DuBois Baileigh G. Hightower Tonya M. Gilbert Nicole R. Zürcher Changning Wang Robert Hopewell Mallar Chakravarty Melissa Savard Emilie Thomas Sara Mohaddes Sarah Farzin Alyssa Salaciak Stephanie Tullo A. Claudio Cuello Jean-Paul Soucy Gassan Massarweh Heungsun Hwang Eliane Kobayashi Bradley T. Hyman Bradford C. Dickerson Marie-Christine Guiot Moshe Szyf Serge Gauthier Jacob M. Hooker Pedro Rosa-Neto |
| author_sort | Tharick A. Pascoal |
| collection | DOAJ |
| description | The link between amyloid and tau proteins with Alzheimer’s disease progression remains unclear. Here, the authors propose HDACs I downregulation as an element linking the deleterious effects of brain proteinopathies with disease progression. |
| first_indexed | 2024-12-11T23:54:05Z |
| format | Article |
| id | doaj.art-fa6fec43d93b4296b1333a2f0ecd7e12 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T23:54:05Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fa6fec43d93b4296b1333a2f0ecd7e122022-12-22T00:45:24ZengNature PortfolioNature Communications2041-17232022-07-0113111110.1038/s41467-022-30653-5[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s diseaseTharick A. Pascoal0Mira Chamoun1Elad Lax2Hsiao-Ying Wey3Monica Shin4Kok Pin Ng5Min Su Kang6Sulantha Mathotaarachchi7Andrea L. Benedet8Joseph Therriault9Firoza Z. Lussier10Frederick A. Schroeder11Jonathan M. DuBois12Baileigh G. Hightower13Tonya M. Gilbert14Nicole R. Zürcher15Changning Wang16Robert Hopewell17Mallar Chakravarty18Melissa Savard19Emilie Thomas20Sara Mohaddes21Sarah Farzin22Alyssa Salaciak23Stephanie Tullo24A. Claudio Cuello25Jean-Paul Soucy26Gassan Massarweh27Heungsun Hwang28Eliane Kobayashi29Bradley T. Hyman30Bradford C. Dickerson31Marie-Christine Guiot32Moshe Szyf33Serge Gauthier34Jacob M. Hooker35Pedro Rosa-Neto36Translational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityDepartment of Molecular Biology, Ariel UniversityDepartment of Pharmacology and Therapeutics, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolMontreal Neurological Institute, McGill UniversityDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging CentreTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging CentreDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging CentreDepartments of Biological and Biomedical Engineering and Psychiatry, Douglas Mental Health University Institute, Brain Imaging CentreDepartment of Pharmacology and Therapeutics, McGill UniversityMontreal Neurological Institute, McGill UniversityMontreal Neurological Institute, McGill UniversityDepartment of Psychology, McGill UniversityMontreal Neurological Institute, McGill UniversityDepartment of Neurology, Massachusetts General Hospital, Harvard Medical SchoolNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolMontreal Neurological Institute, McGill UniversityDepartment of Pharmacology and Therapeutics, McGill UniversityTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityNeurology Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical SchoolTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Faculty of Medicine, The McGill University Research Centre for Studies in Aging, McGill UniversityThe link between amyloid and tau proteins with Alzheimer’s disease progression remains unclear. Here, the authors propose HDACs I downregulation as an element linking the deleterious effects of brain proteinopathies with disease progression.https://doi.org/10.1038/s41467-022-30653-5 |
| spellingShingle | Tharick A. Pascoal Mira Chamoun Elad Lax Hsiao-Ying Wey Monica Shin Kok Pin Ng Min Su Kang Sulantha Mathotaarachchi Andrea L. Benedet Joseph Therriault Firoza Z. Lussier Frederick A. Schroeder Jonathan M. DuBois Baileigh G. Hightower Tonya M. Gilbert Nicole R. Zürcher Changning Wang Robert Hopewell Mallar Chakravarty Melissa Savard Emilie Thomas Sara Mohaddes Sarah Farzin Alyssa Salaciak Stephanie Tullo A. Claudio Cuello Jean-Paul Soucy Gassan Massarweh Heungsun Hwang Eliane Kobayashi Bradley T. Hyman Bradford C. Dickerson Marie-Christine Guiot Moshe Szyf Serge Gauthier Jacob M. Hooker Pedro Rosa-Neto [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease Nature Communications |
| title | [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease |
| title_full | [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease |
| title_fullStr | [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease |
| title_full_unstemmed | [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease |
| title_short | [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease |
| title_sort | 11c martinostat pet analysis reveals reduced hdac i availability in alzheimer s disease |
| url | https://doi.org/10.1038/s41467-022-30653-5 |
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