Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoning
Hydrogen cyanamide (Dormex) is a plant growth regulator that is classified as a highly toxic poison. There are no definite investigations to help in its diagnosis and follow-up. This study aimed to investigate the role of hypoxia-inducible factor-1α (HIF-1α) in the diagnosis, prediction, and follow-...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323003512 |
| _version_ | 1797840611401793536 |
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| author | Meriam N.N. Rezk Gerges M. Beshreda Dalia Abdelrahman Meshref Walaa Yehia Abdelzaher Gaber El-Saber Batiha Amin A. Hafiz Duaa Althumairy Nada H. Aljarba Nermeen N. Welson |
| author_facet | Meriam N.N. Rezk Gerges M. Beshreda Dalia Abdelrahman Meshref Walaa Yehia Abdelzaher Gaber El-Saber Batiha Amin A. Hafiz Duaa Althumairy Nada H. Aljarba Nermeen N. Welson |
| author_sort | Meriam N.N. Rezk |
| collection | DOAJ |
| description | Hydrogen cyanamide (Dormex) is a plant growth regulator that is classified as a highly toxic poison. There are no definite investigations to help in its diagnosis and follow-up. This study aimed to investigate the role of hypoxia-inducible factor-1α (HIF-1α) in the diagnosis, prediction, and follow-up of Dormex-intoxicated patients. Sixty subjects were equally divided into two groups: group A, the control group, and group B, the Dormex group. Clinical and laboratory evaluations, including arterial blood gases (ABG), prothrombin concentration (PC), the international normalized ratio (INR), a complete blood count (CBC), and HIF-1α, were done on admission. CBC and HIF-1α were repeated for group B 24 and 48 h after admission to track abnormalities. Group B also had brain computed tomography (CT). Patients with abnormal CT scans were referred for brain magnetic resonance imaging (MRI). Significant differences in levels of HB, WBCs, and platelets were also detected in group B up to 48 h after admission, as white blood cells (WBCs) rose with time and hemoglobin (HB) and platelets diminished. The results described a highly significant difference in HIF-1α between the groups, and it depended on the clinical condition; therefore, it can be used in the prediction and follow-up of patients up to 24 h after admission. |
| first_indexed | 2024-04-09T16:17:41Z |
| format | Article |
| id | doaj.art-fa6fed0cf4ec4249845e47dd42e84779 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-04-09T16:17:41Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-fa6fed0cf4ec4249845e47dd42e847792023-04-24T04:36:47ZengElsevierEcotoxicology and Environmental Safety0147-65132023-05-01256114847Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoningMeriam N.N. Rezk0Gerges M. Beshreda1Dalia Abdelrahman Meshref2Walaa Yehia Abdelzaher3Gaber El-Saber Batiha4Amin A. Hafiz5Duaa Althumairy6Nada H. Aljarba7Nermeen N. Welson8Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Minia University, Minia 61511, EgyptDepartment of Diagnostic Radiology, Faculty of Medicine, Minia University, Minia 61511, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Minia University, Minia 61511, EgyptDepartment of Pharmacology, Faculty of Medicine, Minia University, Minia 61511, EgyptDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, EgyptDepartment of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al, Qura University, Saudi ArabiaDepartment of Biological Sciences, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaDepartment of Forensic Medicine and Clinical toxicology, Faculty of Medicine, Beni-Suef University, 62511 Beni Suef, Egypt; Corresponding author.Hydrogen cyanamide (Dormex) is a plant growth regulator that is classified as a highly toxic poison. There are no definite investigations to help in its diagnosis and follow-up. This study aimed to investigate the role of hypoxia-inducible factor-1α (HIF-1α) in the diagnosis, prediction, and follow-up of Dormex-intoxicated patients. Sixty subjects were equally divided into two groups: group A, the control group, and group B, the Dormex group. Clinical and laboratory evaluations, including arterial blood gases (ABG), prothrombin concentration (PC), the international normalized ratio (INR), a complete blood count (CBC), and HIF-1α, were done on admission. CBC and HIF-1α were repeated for group B 24 and 48 h after admission to track abnormalities. Group B also had brain computed tomography (CT). Patients with abnormal CT scans were referred for brain magnetic resonance imaging (MRI). Significant differences in levels of HB, WBCs, and platelets were also detected in group B up to 48 h after admission, as white blood cells (WBCs) rose with time and hemoglobin (HB) and platelets diminished. The results described a highly significant difference in HIF-1α between the groups, and it depended on the clinical condition; therefore, it can be used in the prediction and follow-up of patients up to 24 h after admission.http://www.sciencedirect.com/science/article/pii/S0147651323003512Hydrogen cyanamideDormexHypoxia-inducible factor-1α (HIF-1α)Follow up |
| spellingShingle | Meriam N.N. Rezk Gerges M. Beshreda Dalia Abdelrahman Meshref Walaa Yehia Abdelzaher Gaber El-Saber Batiha Amin A. Hafiz Duaa Althumairy Nada H. Aljarba Nermeen N. Welson Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoning Ecotoxicology and Environmental Safety Hydrogen cyanamide Dormex Hypoxia-inducible factor-1α (HIF-1α) Follow up |
| title | Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoning |
| title_full | Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoning |
| title_fullStr | Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoning |
| title_full_unstemmed | Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoning |
| title_short | Hypoxia inducible factor-1α (HIF-1α) as an early predictor of acute hydrogen cyanamide (Dormex) poisoning |
| title_sort | hypoxia inducible factor 1α hif 1α as an early predictor of acute hydrogen cyanamide dormex poisoning |
| topic | Hydrogen cyanamide Dormex Hypoxia-inducible factor-1α (HIF-1α) Follow up |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323003512 |
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