A Review of the Bacterial Phosphoproteomes of Beneficial Microbes
The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/4/931 |
| _version_ | 1797604280698404864 |
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| author | Sooa Lim |
| author_facet | Sooa Lim |
| author_sort | Sooa Lim |
| collection | DOAJ |
| description | The number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority of modified proteins exhibit substoichiometric modification levels, which makes structural and functional analyses challenging. In addition, the number of modified enzymes in bacterial species differs widely, and degrees of proteome modification depend on environmental conditions. Nevertheless, evidence suggests that protein PTMs play essential roles in various cellular processes, including nitrogen metabolism, protein synthesis and turnover, the cell cycle, dormancy, spore germination, sporulation, persistence, and virulence. Additional investigations on protein post-translational changes will undoubtedly close knowledge gaps in bacterial physiology and create new means of treating infectious diseases. Here, we describe the role of the post-translation phosphorylation of major bacterial proteins and review the progress of research on phosphorylated proteins depending on bacterial species. |
| first_indexed | 2024-03-11T04:44:12Z |
| format | Article |
| id | doaj.art-fa70801e562f4401b4e06cc5ddea6164 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T04:44:12Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-fa70801e562f4401b4e06cc5ddea61642023-11-17T20:32:36ZengMDPI AGMicroorganisms2076-26072023-04-0111493110.3390/microorganisms11040931A Review of the Bacterial Phosphoproteomes of Beneficial MicrobesSooa Lim0Department of Pharmaceutical Engineering, Hoseo University, Asan-si 31499, Republic of KoreaThe number and variety of protein post-translational modifications (PTMs) found and characterized in bacteria over the past ten years have increased dramatically. Compared to eukaryotic proteins, most post-translational protein changes in bacteria affect relatively few proteins because the majority of modified proteins exhibit substoichiometric modification levels, which makes structural and functional analyses challenging. In addition, the number of modified enzymes in bacterial species differs widely, and degrees of proteome modification depend on environmental conditions. Nevertheless, evidence suggests that protein PTMs play essential roles in various cellular processes, including nitrogen metabolism, protein synthesis and turnover, the cell cycle, dormancy, spore germination, sporulation, persistence, and virulence. Additional investigations on protein post-translational changes will undoubtedly close knowledge gaps in bacterial physiology and create new means of treating infectious diseases. Here, we describe the role of the post-translation phosphorylation of major bacterial proteins and review the progress of research on phosphorylated proteins depending on bacterial species.https://www.mdpi.com/2076-2607/11/4/931microorganismsbacteriaproteinspost-translational modifications (PTMs)signal transductionphosphorylation |
| spellingShingle | Sooa Lim A Review of the Bacterial Phosphoproteomes of Beneficial Microbes Microorganisms microorganisms bacteria proteins post-translational modifications (PTMs) signal transduction phosphorylation |
| title | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
| title_full | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
| title_fullStr | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
| title_full_unstemmed | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
| title_short | A Review of the Bacterial Phosphoproteomes of Beneficial Microbes |
| title_sort | review of the bacterial phosphoproteomes of beneficial microbes |
| topic | microorganisms bacteria proteins post-translational modifications (PTMs) signal transduction phosphorylation |
| url | https://www.mdpi.com/2076-2607/11/4/931 |
| work_keys_str_mv | AT sooalim areviewofthebacterialphosphoproteomesofbeneficialmicrobes AT sooalim reviewofthebacterialphosphoproteomesofbeneficialmicrobes |