Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study
BackgroundThe contribution of total fat mass and regional fat distribution to the risk of AF has rarely been studied.MethodsThis prospective cohort study(N=494,063) evaluated the association of total fat mass measured by fat percentage (FP) and regional fat measured by arm fat percentage (AFP), trun...
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| Format: | Article |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1367653/full |
| _version_ | 1797249319984693248 |
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| author | Chenkai Wu Yuefei Xu Zhenhua Xing Zhenhua Xing |
| author_facet | Chenkai Wu Yuefei Xu Zhenhua Xing Zhenhua Xing |
| author_sort | Chenkai Wu |
| collection | DOAJ |
| description | BackgroundThe contribution of total fat mass and regional fat distribution to the risk of AF has rarely been studied.MethodsThis prospective cohort study(N=494,063) evaluated the association of total fat mass measured by fat percentage (FP) and regional fat measured by arm fat percentage (AFP), trunk fat percentage (TFP), and leg fat percentage (LFP) with incident AF. A subgroup (N = 25,581) underwent MRI, which allowed us to further assess whether visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) of the trunk fat exert different effects on AF incidence.ResultsOver, a median 12.9 ± 1.86 years of follow-up, 29,658 participants (cumulative rate: 6.0%) developed AF. Each 1-standard deviation (SD) increase in LFP was associated with a 16% lower risk of AF (HR: 0.84, 95% CI: 0.82, 0.85). The association between FP and AF was weaker than that between LFP and AF (HR: 0.90, 95% CI: 0.89, 0.92). AFP and TFP only had a marginal association with a lower incidence of AF. Both the VAT and ASAT showed a U-shaped relationship with incident AF.ConclusionsFat mass, mainly leg fat mass, was associated with a lower risk of AF. ASAT did not exert protective effects. |
| first_indexed | 2024-04-24T20:28:36Z |
| format | Article |
| id | doaj.art-fa7126f38c744ecb90e8fcfbe1d0a159 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T20:28:36Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-fa7126f38c744ecb90e8fcfbe1d0a1592024-03-22T04:31:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13676531367653Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort studyChenkai Wu0Yuefei Xu1Zhenhua Xing2Zhenhua Xing3Department of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Cardiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, ChinaEmergency Medicine and Difficult Diseases Institute, Central South University, Changsha, Hunan, ChinaBackgroundThe contribution of total fat mass and regional fat distribution to the risk of AF has rarely been studied.MethodsThis prospective cohort study(N=494,063) evaluated the association of total fat mass measured by fat percentage (FP) and regional fat measured by arm fat percentage (AFP), trunk fat percentage (TFP), and leg fat percentage (LFP) with incident AF. A subgroup (N = 25,581) underwent MRI, which allowed us to further assess whether visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) of the trunk fat exert different effects on AF incidence.ResultsOver, a median 12.9 ± 1.86 years of follow-up, 29,658 participants (cumulative rate: 6.0%) developed AF. Each 1-standard deviation (SD) increase in LFP was associated with a 16% lower risk of AF (HR: 0.84, 95% CI: 0.82, 0.85). The association between FP and AF was weaker than that between LFP and AF (HR: 0.90, 95% CI: 0.89, 0.92). AFP and TFP only had a marginal association with a lower incidence of AF. Both the VAT and ASAT showed a U-shaped relationship with incident AF.ConclusionsFat mass, mainly leg fat mass, was associated with a lower risk of AF. ASAT did not exert protective effects.https://www.frontiersin.org/articles/10.3389/fendo.2024.1367653/fullfat mass distributiontotal fat massatrial fibrillationvisceral adipose tissueabdominal subcutaneous adipose tissue |
| spellingShingle | Chenkai Wu Yuefei Xu Zhenhua Xing Zhenhua Xing Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study Frontiers in Endocrinology fat mass distribution total fat mass atrial fibrillation visceral adipose tissue abdominal subcutaneous adipose tissue |
| title | Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study |
| title_full | Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study |
| title_fullStr | Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study |
| title_full_unstemmed | Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study |
| title_short | Exploring the association between regional fat distribution and atrial fibrillation risks: a comprehensive cohort study |
| title_sort | exploring the association between regional fat distribution and atrial fibrillation risks a comprehensive cohort study |
| topic | fat mass distribution total fat mass atrial fibrillation visceral adipose tissue abdominal subcutaneous adipose tissue |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1367653/full |
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