Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts
Abstract After a century of investigations, the function of the obligate betaproteobacterial endosymbionts accommodated in leaf nodules of tropical Rubiaceae remained enigmatic. We report that the α-d-glucose analogue (+)-streptol, systemically supplied by mature Ca. Burkholderia kirkii nodules to t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01867-2 |
| _version_ | 1818407249449582592 |
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| author | Antri Georgiou Simon Sieber Chien-Chi Hsiao Tatyana Grayfer Jacob L. Gorenflos López Karl Gademann Leo Eberl Aurélien Bailly |
| author_facet | Antri Georgiou Simon Sieber Chien-Chi Hsiao Tatyana Grayfer Jacob L. Gorenflos López Karl Gademann Leo Eberl Aurélien Bailly |
| author_sort | Antri Georgiou |
| collection | DOAJ |
| description | Abstract After a century of investigations, the function of the obligate betaproteobacterial endosymbionts accommodated in leaf nodules of tropical Rubiaceae remained enigmatic. We report that the α-d-glucose analogue (+)-streptol, systemically supplied by mature Ca. Burkholderia kirkii nodules to their Psychotria hosts, exhibits potent and selective root growth inhibiting activity. We provide compelling evidence that (+)-streptol specifically affects meristematic root cells transitioning to anisotropic elongation by disrupting cell wall organization in a mechanism of action that is distinct from canonical cellulose biosynthesis inhibitors. We observed no inhibitory or cytotoxic effects on organisms other than seed plants, further suggesting (+)-streptol as a bona fide allelochemical. We propose that the suppression of growth of plant competitors is a major driver of the formation and maintenance of the Psychotria–Burkholderia association. In addition to potential agricultural applications as a herbicidal agent, (+)-streptol might also prove useful to dissect plant cell and organ growth processes. |
| first_indexed | 2024-12-14T09:24:50Z |
| format | Article |
| id | doaj.art-fa73c84b271f49648365643bfb033395 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T09:24:50Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fa73c84b271f49648365643bfb0333952022-12-21T23:08:13ZengNature PortfolioScientific Reports2045-23222021-11-0111111510.1038/s41598-021-01867-2Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hostsAntri Georgiou0Simon Sieber1Chien-Chi Hsiao2Tatyana Grayfer3Jacob L. Gorenflos López4Karl Gademann5Leo Eberl6Aurélien Bailly7Institute of Plant and Microbial Biology, University of ZürichDepartment of Chemistry, University of ZürichDepartment of Chemistry, University of ZürichDepartment of Chemistry, University of ZürichDepartment of Chemistry, University of ZürichDepartment of Chemistry, University of ZürichInstitute of Plant and Microbial Biology, University of ZürichInstitute of Plant and Microbial Biology, University of ZürichAbstract After a century of investigations, the function of the obligate betaproteobacterial endosymbionts accommodated in leaf nodules of tropical Rubiaceae remained enigmatic. We report that the α-d-glucose analogue (+)-streptol, systemically supplied by mature Ca. Burkholderia kirkii nodules to their Psychotria hosts, exhibits potent and selective root growth inhibiting activity. We provide compelling evidence that (+)-streptol specifically affects meristematic root cells transitioning to anisotropic elongation by disrupting cell wall organization in a mechanism of action that is distinct from canonical cellulose biosynthesis inhibitors. We observed no inhibitory or cytotoxic effects on organisms other than seed plants, further suggesting (+)-streptol as a bona fide allelochemical. We propose that the suppression of growth of plant competitors is a major driver of the formation and maintenance of the Psychotria–Burkholderia association. In addition to potential agricultural applications as a herbicidal agent, (+)-streptol might also prove useful to dissect plant cell and organ growth processes.https://doi.org/10.1038/s41598-021-01867-2 |
| spellingShingle | Antri Georgiou Simon Sieber Chien-Chi Hsiao Tatyana Grayfer Jacob L. Gorenflos López Karl Gademann Leo Eberl Aurélien Bailly Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts Scientific Reports |
| title | Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts |
| title_full | Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts |
| title_fullStr | Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts |
| title_full_unstemmed | Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts |
| title_short | Leaf nodule endosymbiotic Burkholderia confer targeted allelopathy to their Psychotria hosts |
| title_sort | leaf nodule endosymbiotic burkholderia confer targeted allelopathy to their psychotria hosts |
| url | https://doi.org/10.1038/s41598-021-01867-2 |
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