Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil
Introduction and objectives: Little is known about the etiology of acute liver failure (ALF) in Latin America. The objective of this paper is to investigate the main etiologies of ALF in Brazil, including Drug Induced Liver Injury (DILI) using stringent causality criteria. Patients or material and m...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268121000090 |
| _version_ | 1818437240525684736 |
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| author | Genario Santos Estela Regina Ramos Figueira Luiz Augusto Carneiro D’Albuquerque Paulo Bittencourt Lisboa Marcio Dias de Almeida Norma Arteiro Filgueira Ilka Boin Gilda Porta Rita de Cássia Martins Alves da Silva Cyntia Ferreira Gomes Viana Luciana Costa Faria Mario Reis Alvares-da-Silva Adriano Claudio Pereira de Moraes Daphne Benatti Goncalves Morsoletto Liana Codes Raymundo Paraná |
| author_facet | Genario Santos Estela Regina Ramos Figueira Luiz Augusto Carneiro D’Albuquerque Paulo Bittencourt Lisboa Marcio Dias de Almeida Norma Arteiro Filgueira Ilka Boin Gilda Porta Rita de Cássia Martins Alves da Silva Cyntia Ferreira Gomes Viana Luciana Costa Faria Mario Reis Alvares-da-Silva Adriano Claudio Pereira de Moraes Daphne Benatti Goncalves Morsoletto Liana Codes Raymundo Paraná |
| author_sort | Genario Santos |
| collection | DOAJ |
| description | Introduction and objectives: Little is known about the etiology of acute liver failure (ALF) in Latin America. The objective of this paper is to investigate the main etiologies of ALF in Brazil, including Drug Induced Liver Injury (DILI) using stringent causality criteria. Patients or material and methods: All the cases of individuals who underwent liver transplantation (LT) in 12 centers in Brazil for ALF were reviewed. When DILI was stated as the cause of ALF, causality criteria were applied on site by the main investigator in order to rule out other etiologies. Results: 325 individuals had ALF mainly for unknown reasons (34%), DILI (27%) and AIH (18%). Reassessment of the 89 cases of DILI, using stringent causality criteria, revealed that in only 42 subjects could DILI be confirmed as the cause of ALF. Acetaminophen (APAP) toxicity (n = 3) or DILI due to herbal and dietary supplements (HDS) (n = 2) were not commonly observed. Conclusions: Undetermined etiology and DILI are the main causes of ALF in Brazil. However, APAP toxicity and DILI due to HDS are mostly uncommon. |
| first_indexed | 2024-12-14T17:21:32Z |
| format | Article |
| id | doaj.art-fa74ecece4754924825cee15daf77c26 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-14T17:21:32Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-fa74ecece4754924825cee15daf77c262022-12-21T22:53:20ZengElsevierAnnals of Hepatology1665-26812021-07-0123100310Evaluation of drug-induced liver injury as etiology for acute liver failure in BrazilGenario Santos0Estela Regina Ramos Figueira1Luiz Augusto Carneiro D’Albuquerque2Paulo Bittencourt Lisboa3Marcio Dias de Almeida4Norma Arteiro Filgueira5Ilka Boin6Gilda Porta7Rita de Cássia Martins Alves da Silva8Cyntia Ferreira Gomes Viana9Luciana Costa Faria10Mario Reis Alvares-da-Silva11Adriano Claudio Pereira de Moraes12Daphne Benatti Goncalves Morsoletto13Liana Codes14Raymundo Paraná15Health Science Postgraduation, Faculty of Medicine, University Federal of Bahia, Brazil; Corresponding author at: Prof. Edgard Santos University Hospital of the Federal University of Bahia, Dr. Augusto Viana Street, Canela, 40110060 Salvador, Bahia, Brazil.Department of Gastroenterology, Division of Digestive Surgery, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilDepartment of Gastroenterology, Division of Digestive Surgery, Hospital das Clinicas of University of Sao Paulo School of Medicine, Sao Paulo, BrazilUnit of Gastroenterology and Hepatology, Portuguese Hospital, Salvador-BA, Brazil.Albert Einstein Israelite Hospital, São Paulo, BrazilDepartment of Internal Medicine, University Federal of Pernambuco, BrazilMedical Sciences Faculty of Campinas State University, Campinas, São Paulo, BrazilDepartment of Pediatrics, Children’s Institute, Medical School of the University of São Paulo, São Paulo, BrazilSão José do Rio Preto Medical School (FAMERP), São José do Rio Preto- SP, BrazilLiver Transplant Center of Ceara, Walter Cantidio Universitary Hospital, Fortaleza- CE, BrazilDepartment of Internal Medicine, Federal University of Minas Gerais, School of Medicine, Belo Horizonte-MG, BrazilGastroenterology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre - RS, BrazilUnit of Liver Transplantation, Cardiology Institute of Federal District, Federal District, BrazilNossa Senhora das Graças Hospital, Curitiba - PR, BrazilUnit of Gastroenterology and Hepatology, Portuguese Hospital, Salvador-BA, Brazil.Health Science Postgraduation, Faculty of Medicine, University Federal of Bahia, BrazilIntroduction and objectives: Little is known about the etiology of acute liver failure (ALF) in Latin America. The objective of this paper is to investigate the main etiologies of ALF in Brazil, including Drug Induced Liver Injury (DILI) using stringent causality criteria. Patients or material and methods: All the cases of individuals who underwent liver transplantation (LT) in 12 centers in Brazil for ALF were reviewed. When DILI was stated as the cause of ALF, causality criteria were applied on site by the main investigator in order to rule out other etiologies. Results: 325 individuals had ALF mainly for unknown reasons (34%), DILI (27%) and AIH (18%). Reassessment of the 89 cases of DILI, using stringent causality criteria, revealed that in only 42 subjects could DILI be confirmed as the cause of ALF. Acetaminophen (APAP) toxicity (n = 3) or DILI due to herbal and dietary supplements (HDS) (n = 2) were not commonly observed. Conclusions: Undetermined etiology and DILI are the main causes of ALF in Brazil. However, APAP toxicity and DILI due to HDS are mostly uncommon.http://www.sciencedirect.com/science/article/pii/S1665268121000090Drug induced liver injuryAcute liver failureLiver injury |
| spellingShingle | Genario Santos Estela Regina Ramos Figueira Luiz Augusto Carneiro D’Albuquerque Paulo Bittencourt Lisboa Marcio Dias de Almeida Norma Arteiro Filgueira Ilka Boin Gilda Porta Rita de Cássia Martins Alves da Silva Cyntia Ferreira Gomes Viana Luciana Costa Faria Mario Reis Alvares-da-Silva Adriano Claudio Pereira de Moraes Daphne Benatti Goncalves Morsoletto Liana Codes Raymundo Paraná Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil Annals of Hepatology Drug induced liver injury Acute liver failure Liver injury |
| title | Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil |
| title_full | Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil |
| title_fullStr | Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil |
| title_full_unstemmed | Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil |
| title_short | Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil |
| title_sort | evaluation of drug induced liver injury as etiology for acute liver failure in brazil |
| topic | Drug induced liver injury Acute liver failure Liver injury |
| url | http://www.sciencedirect.com/science/article/pii/S1665268121000090 |
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