Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry
BackgroundThe outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125030/full |
| _version_ | 1828004705378238464 |
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| author | Alessandro Busca Jon Salmanton-García Jon Salmanton-García Francesco Marchesi Francesca Farina Guldane Cengiz Seval Jaap Van Doesum Nick De Jonge Nathan C. Bahr Johan Maertens Johan Maertens Joseph Meletiadis Nicola S. Fracchiolla Barbora Weinbergerová Luisa Verga Luisa Verga Zdeněk Ráčil Moraima Jiménez Moraima Jiménez Andreas Glenthøj Ola Blennow Alina Daniela Tanase Martin Schönlein Lucia Prezioso Nina Khanna Rafael F. Duarte Pavel Žák Marcio Nucci Marina Machado Austin Kulasekararaj Austin Kulasekararaj Ildefonso Espigado Elizabeth De Kort José-María Ribera-Santa Susana Monia Marchetti Gabriele Magliano Iker Falces-Romero Osman Ilhan Emanuele Ammatuna Sofia Zompi Panagiotis Tsirigotis Anastasia Antoniadou Giovanni Paolo Maria Zambrotta Giovanni Paolo Maria Zambrotta Anna Nordlander Linda Katharina Karlsson Michaela Hanakova Giulia Dragonetti Alba Cabirta Caroline Berg Venemyr Stefanie Gräfe Stefanie Gräfe Jens Van Praet Athanasios Tragiannidis Verena Petzer Alberto López-García Federico Itri Ana Groh Eleni Gavriilaki Michelina Dargenio Laman Rahimli Laman Rahimli Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Livio Pagano EPICOVIDEHA Consortium Juergen Prattes Malgorzata Mikulska Gustavo-Adolfo Méndez Tobias Lahmer Pavel Jindra Anna Guidetti Rita Fazzi Maria Ilaria Del Principe Cristina De Ramón Maria Calbacho Zlate Stojanoski Andrés Soto Alexandra Serris Irati Ormazabal-Vélez Ali S. Omrani Milan Navrátil Sonia Martín-Pérez Joyce Marques De Almeida Sylvain Lamure Martin Kolditz Ozren Jaksic Martin Hoenigl Carolina Garcia-Vidal Noemí Fernández Shaimaa El-Ashwah Natasha Čolović Martin Čerňan Caterina Buquicchio Valentina Bonuomo Josip Batinić Murtadha Al-Khabori Tatjana Adžić-Vukičević Juan-Alberto Martín-González Maria Vittoria Sacchi María-Josefa Jiménez-Lorenzo Dominik Wolf Maria Vehreschild Raul Cordoba Ramón García-Sanz Toni Valković Miloš Mladenović Nicole García-Poutón Ziad Emarah Julio Dávila-Valls |
| author_facet | Alessandro Busca Jon Salmanton-García Jon Salmanton-García Francesco Marchesi Francesca Farina Guldane Cengiz Seval Jaap Van Doesum Nick De Jonge Nathan C. Bahr Johan Maertens Johan Maertens Joseph Meletiadis Nicola S. Fracchiolla Barbora Weinbergerová Luisa Verga Luisa Verga Zdeněk Ráčil Moraima Jiménez Moraima Jiménez Andreas Glenthøj Ola Blennow Alina Daniela Tanase Martin Schönlein Lucia Prezioso Nina Khanna Rafael F. Duarte Pavel Žák Marcio Nucci Marina Machado Austin Kulasekararaj Austin Kulasekararaj Ildefonso Espigado Elizabeth De Kort José-María Ribera-Santa Susana Monia Marchetti Gabriele Magliano Iker Falces-Romero Osman Ilhan Emanuele Ammatuna Sofia Zompi Panagiotis Tsirigotis Anastasia Antoniadou Giovanni Paolo Maria Zambrotta Giovanni Paolo Maria Zambrotta Anna Nordlander Linda Katharina Karlsson Michaela Hanakova Giulia Dragonetti Alba Cabirta Caroline Berg Venemyr Stefanie Gräfe Stefanie Gräfe Jens Van Praet Athanasios Tragiannidis Verena Petzer Alberto López-García Federico Itri Ana Groh Eleni Gavriilaki Michelina Dargenio Laman Rahimli Laman Rahimli Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Livio Pagano EPICOVIDEHA Consortium Juergen Prattes Malgorzata Mikulska Gustavo-Adolfo Méndez Tobias Lahmer Pavel Jindra Anna Guidetti Rita Fazzi Maria Ilaria Del Principe Cristina De Ramón Maria Calbacho Zlate Stojanoski Andrés Soto Alexandra Serris Irati Ormazabal-Vélez Ali S. Omrani Milan Navrátil Sonia Martín-Pérez Joyce Marques De Almeida Sylvain Lamure Martin Kolditz Ozren Jaksic Martin Hoenigl Carolina Garcia-Vidal Noemí Fernández Shaimaa El-Ashwah Natasha Čolović Martin Čerňan Caterina Buquicchio Valentina Bonuomo Josip Batinić Murtadha Al-Khabori Tatjana Adžić-Vukičević Juan-Alberto Martín-González Maria Vittoria Sacchi María-Josefa Jiménez-Lorenzo Dominik Wolf Maria Vehreschild Raul Cordoba Ramón García-Sanz Toni Valković Miloš Mladenović Nicole García-Poutón Ziad Emarah Julio Dávila-Valls |
| author_sort | Alessandro Busca |
| collection | DOAJ |
| description | BackgroundThe outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection after an allogeneic HSCT.MethodsThis multicenter retrospective study promoted by the European Hematology Association – Infections in Hematology Study Working Group, included 326 adult HSCT patients who had COVID-19 between January 2020 and March 2022.ResultsThe median time from HSCT to the diagnosis of COVID-19 was 268 days (IQR 86-713; range 0-185 days). COVID-19 severity was mild in 21% of the patients, severe in 39% and critical in 16% of the patients. In multivariable analysis factors associated with a higher risk of mortality were, age above 50 years, presence of 3 or more comorbidities, active hematologic disease at time of COVID-19 infection, development of COVID-19 within 12 months of HSCT, and severe/critical infections. Overall mortality rate was 21% (n=68): COVID-19 was the main or secondary cause of death in 16% of the patients (n=53).ConclusionsMortality in HSCT recipients who develop COVID-19 is high and largely dependent on age, comorbidities, active hematologic disease, timing from transplant and severity of the infection. |
| first_indexed | 2024-04-10T07:20:15Z |
| format | Article |
| id | doaj.art-fa75c6f7646a43b480aeb8652e873a01 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T07:20:15Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fa75c6f7646a43b480aeb8652e873a012023-02-24T13:48:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11250301125030Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registryAlessandro Busca0Jon Salmanton-García1Jon Salmanton-García2Francesco Marchesi3Francesca Farina4Guldane Cengiz Seval5Jaap Van Doesum6Nick De Jonge7Nathan C. Bahr8Johan Maertens9Johan Maertens10Joseph Meletiadis11Nicola S. Fracchiolla12Barbora Weinbergerová13Luisa Verga14Luisa Verga15Zdeněk Ráčil16Moraima Jiménez17Moraima Jiménez18Andreas Glenthøj19Ola Blennow20Alina Daniela Tanase21Martin Schönlein22Lucia Prezioso23Nina Khanna24Rafael F. Duarte25Pavel Žák26Marcio Nucci27Marina Machado28Austin Kulasekararaj29Austin Kulasekararaj30Ildefonso Espigado31Elizabeth De Kort32José-María Ribera-Santa Susana33Monia Marchetti34Gabriele Magliano35Iker Falces-Romero36Osman Ilhan37Emanuele Ammatuna38Sofia Zompi39Panagiotis Tsirigotis40Anastasia Antoniadou41Giovanni Paolo Maria Zambrotta42Giovanni Paolo Maria Zambrotta43Anna Nordlander44Linda Katharina Karlsson45Michaela Hanakova46Giulia Dragonetti47Alba Cabirta48Caroline Berg Venemyr49Stefanie Gräfe50Stefanie Gräfe51Jens Van Praet52Athanasios Tragiannidis53Verena Petzer54Alberto López-García55Federico Itri56Ana Groh57Eleni Gavriilaki58Michelina Dargenio59Laman Rahimli60Laman Rahimli61Oliver A. Cornely62Oliver A. Cornely63Oliver A. Cornely64Oliver A. Cornely65Oliver A. Cornely66Livio Pagano67EPICOVIDEHA ConsortiumJuergen PrattesMalgorzata MikulskaGustavo-Adolfo MéndezTobias LahmerPavel JindraAnna GuidettiRita FazziMaria Ilaria Del PrincipeCristina De RamónMaria CalbachoZlate StojanoskiAndrés SotoAlexandra SerrisIrati Ormazabal-VélezAli S. OmraniMilan NavrátilSonia Martín-PérezJoyce Marques De AlmeidaSylvain LamureMartin KolditzOzren JaksicMartin HoeniglCarolina Garcia-VidalNoemí FernándezShaimaa El-AshwahNatasha ČolovićMartin ČerňanCaterina BuquicchioValentina BonuomoJosip BatinićMurtadha Al-KhaboriTatjana Adžić-VukičevićJuan-Alberto Martín-GonzálezMaria Vittoria SacchiMaría-Josefa Jiménez-LorenzoDominik WolfMaria VehreschildRaul CordobaRamón García-SanzToni ValkovićMiloš MladenovićNicole García-PoutónZiad EmarahJulio Dávila-VallsStem Cell Transplant Center, AOU Citta’ della Salute e della Scienza, Turin, ItalyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, GermanyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, GermanyHematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, ItalyIRCCS Ospedale San Raffaele, Milan, ItalyAnkara University, Ankara, TürkiyeUniversity Medical Center Groningen, Groningen, NetherlandsAmsterdam UMC, Amsterdam, NetherlandsUniversity of Kansas Medical Center, Kansas, KS, United States0Department of Microbiology, Immunology, and Transplantation, KULeuven, Leuven, Belgium1Department of Hematology, UZ Leuven, Leuven, Belgium2Clinical Microbiology Laboratory, Medical School, “Attikon” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece3Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy4Department of Internal Medicine - Hematology and Oncology, Masaryk University Hospital Brno, Brno, Czechia5Azienda Ospedaliera San Gerardo - Monza, Monza, Italy6Università Milano-Bicocca, Milan, Italy7Institute of Hematology and Blood Transfusion, Prague, Czechia8Department of Hematology, Vall d’Hebron Hospital Universitari, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital, Barcelona, Spain9Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain0Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark1Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden2Fundeni Clinical Institute, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania3Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4Hospital University of Parma - Hematology and Bone Marrow Unit, Parma, Italy5Division of Infectious Diseases and Hospital Epidemiology, and Department of Clinical Research, University and University Hospital of Basel, Basel, Switzerland6Hospital Universitario Puerta de Hierro, Majadahonda, Spain7University Hospital Hradec Králové, Hradec Králové, Czechia8Federal University of Rio de Janeiro, Rio de Janeiro, Brazil9Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain0King’s College Hospital, London, United Kingdom1King’s College London, London, United Kingdom2Department of Hematology, University Hospital Virgen Macarena - University Hospital Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/CSIC), Universidad de Sevilla (Departamento de Medicina), Seville, Spain3Radboudumc, Nijmegen, Netherlands4Clinical Hematology Department, ICO-Hospital germans Trias i Pujol, Josep Carreras Research Institute, Badalona, Spain5Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy6ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy7La Paz University Hospital, Madrid, SpainAnkara University, Ankara, TürkiyeUniversity Medical Center Groningen, Groningen, NetherlandsStem Cell Transplant Center, AOU Citta’ della Salute e della Scienza, Turin, Italy2Clinical Microbiology Laboratory, Medical School, “Attikon” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece2Clinical Microbiology Laboratory, Medical School, “Attikon” University General Hospital, National and Kapodistrian University of Athens, Athens, Greece5Azienda Ospedaliera San Gerardo - Monza, Monza, Italy6Università Milano-Bicocca, Milan, Italy1Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden0Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark7Institute of Hematology and Blood Transfusion, Prague, Czechia8Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli - IRCCS, Rome, Italy8Department of Hematology, Vall d’Hebron Hospital Universitari, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital, Barcelona, Spain0Department of Hematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, DenmarkUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, GermanyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany9Department of Nephrology and Infectious diseases, AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium0Aristotle University of Thessaloniki, Thessaloniki, Greece1Department of Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria2Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain3San Luigi Gonzaga Hospital - Orbassano, Orbassano, Italy4Infektiologie, Universitätsklinikum Frankfurt am Main, Frankfurt am Main, Germany5General Hospital of Thessaloniki “George Papanikolaou”, Thessaloniki, Greece6Hematology and Stem Cell Transplant Unit, Vito Fazzi, LecceUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, GermanyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, GermanyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, GermanyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany7University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), Cologne, Germany8University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany9German Centre for Infection Research (DZIF) , Cologne, Germany0Hematology Unit, Università Cattolica del Sacro Cuore, Rome, ItalyBackgroundThe outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection after an allogeneic HSCT.MethodsThis multicenter retrospective study promoted by the European Hematology Association – Infections in Hematology Study Working Group, included 326 adult HSCT patients who had COVID-19 between January 2020 and March 2022.ResultsThe median time from HSCT to the diagnosis of COVID-19 was 268 days (IQR 86-713; range 0-185 days). COVID-19 severity was mild in 21% of the patients, severe in 39% and critical in 16% of the patients. In multivariable analysis factors associated with a higher risk of mortality were, age above 50 years, presence of 3 or more comorbidities, active hematologic disease at time of COVID-19 infection, development of COVID-19 within 12 months of HSCT, and severe/critical infections. Overall mortality rate was 21% (n=68): COVID-19 was the main or secondary cause of death in 16% of the patients (n=53).ConclusionsMortality in HSCT recipients who develop COVID-19 is high and largely dependent on age, comorbidities, active hematologic disease, timing from transplant and severity of the infection.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125030/fullallogeneic HSCTCOVID-19 infectionimmunocompromised patientsSARS-CoV-2hematological malignances |
| spellingShingle | Alessandro Busca Jon Salmanton-García Jon Salmanton-García Francesco Marchesi Francesca Farina Guldane Cengiz Seval Jaap Van Doesum Nick De Jonge Nathan C. Bahr Johan Maertens Johan Maertens Joseph Meletiadis Nicola S. Fracchiolla Barbora Weinbergerová Luisa Verga Luisa Verga Zdeněk Ráčil Moraima Jiménez Moraima Jiménez Andreas Glenthøj Ola Blennow Alina Daniela Tanase Martin Schönlein Lucia Prezioso Nina Khanna Rafael F. Duarte Pavel Žák Marcio Nucci Marina Machado Austin Kulasekararaj Austin Kulasekararaj Ildefonso Espigado Elizabeth De Kort José-María Ribera-Santa Susana Monia Marchetti Gabriele Magliano Iker Falces-Romero Osman Ilhan Emanuele Ammatuna Sofia Zompi Panagiotis Tsirigotis Anastasia Antoniadou Giovanni Paolo Maria Zambrotta Giovanni Paolo Maria Zambrotta Anna Nordlander Linda Katharina Karlsson Michaela Hanakova Giulia Dragonetti Alba Cabirta Caroline Berg Venemyr Stefanie Gräfe Stefanie Gräfe Jens Van Praet Athanasios Tragiannidis Verena Petzer Alberto López-García Federico Itri Ana Groh Eleni Gavriilaki Michelina Dargenio Laman Rahimli Laman Rahimli Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Oliver A. Cornely Livio Pagano EPICOVIDEHA Consortium Juergen Prattes Malgorzata Mikulska Gustavo-Adolfo Méndez Tobias Lahmer Pavel Jindra Anna Guidetti Rita Fazzi Maria Ilaria Del Principe Cristina De Ramón Maria Calbacho Zlate Stojanoski Andrés Soto Alexandra Serris Irati Ormazabal-Vélez Ali S. Omrani Milan Navrátil Sonia Martín-Pérez Joyce Marques De Almeida Sylvain Lamure Martin Kolditz Ozren Jaksic Martin Hoenigl Carolina Garcia-Vidal Noemí Fernández Shaimaa El-Ashwah Natasha Čolović Martin Čerňan Caterina Buquicchio Valentina Bonuomo Josip Batinić Murtadha Al-Khabori Tatjana Adžić-Vukičević Juan-Alberto Martín-González Maria Vittoria Sacchi María-Josefa Jiménez-Lorenzo Dominik Wolf Maria Vehreschild Raul Cordoba Ramón García-Sanz Toni Valković Miloš Mladenović Nicole García-Poutón Ziad Emarah Julio Dávila-Valls Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry Frontiers in Immunology allogeneic HSCT COVID-19 infection immunocompromised patients SARS-CoV-2 hematological malignances |
| title | Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry |
| title_full | Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry |
| title_fullStr | Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry |
| title_full_unstemmed | Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry |
| title_short | Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry |
| title_sort | outcome of covid 19 in allogeneic stem cell transplant recipients results from the epicovideha registry |
| topic | allogeneic HSCT COVID-19 infection immunocompromised patients SARS-CoV-2 hematological malignances |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125030/full |
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