Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattle
<p>Abstract</p> <p>Background</p> <p>Infestations on cattle by the ectoparasite <it>Boophilus (Rhipicephalus) microplus </it>(cattle tick) impact negatively on animal production systems. Host resistance to tick infestation has a low to moderate heritability...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-06-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/11/55 |
| _version_ | 1811290991691300864 |
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| author | Bunch Rowan J Porto Neto Laercio R Harrison Blair E Prayaga Kishore C Barendse William |
| author_facet | Bunch Rowan J Porto Neto Laercio R Harrison Blair E Prayaga Kishore C Barendse William |
| author_sort | Bunch Rowan J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Infestations on cattle by the ectoparasite <it>Boophilus (Rhipicephalus) microplus </it>(cattle tick) impact negatively on animal production systems. Host resistance to tick infestation has a low to moderate heritability in the range 0.13 - 0.64 in Australia. Previous studies identified a QTL on bovine chromosome 10 (BTA10) linked to tick burden in cattle.</p> <p>Results</p> <p>To confirm these associations, we collected genotypes of 17 SNP from BTA10, including three obtained by sequencing part of the <it>ITGA11 </it>(<it>Integrin alpha 11</it>) gene. Initially, we genotyped 1,055 dairy cattle for the 17 SNP, and then genotyped 557 Brahman and 216 Tropical Composite beef cattle for 11 of the 17 SNP. In total, 7 of the SNP were significantly (<it>P </it>< 0.05) associated with tick burden tested in any of the samples. One SNP, ss161109814, was significantly (<it>P </it>< 0.05) associated with tick burden in both the taurine and the Brahman sample, but the favourable allele was different. Haplotypes for three and for 10 SNP were more significantly (<it>P </it>< 0.001) associated with tick burden than SNP analysed individually. Some of the common haplotypes with the largest sample sizes explained between 1.3% and 1.5% of the residual variance in tick burden.</p> <p>Conclusions</p> <p>These analyses confirm the location of a QTL affecting tick burden on BTA10 and position it close to the <it>ITGA11 </it>gene. The presence of a significant association in such widely divergent animals suggests that further SNP discovery in this region to detect causal mutations would be warranted.</p> |
| first_indexed | 2024-04-13T04:22:42Z |
| format | Article |
| id | doaj.art-fa76061d7c1e4a979ae7cff541079eab |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-04-13T04:22:42Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-fa76061d7c1e4a979ae7cff541079eab2022-12-22T03:02:41ZengBMCBMC Genetics1471-21562010-06-011115510.1186/1471-2156-11-55Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattleBunch Rowan JPorto Neto Laercio RHarrison Blair EPrayaga Kishore CBarendse William<p>Abstract</p> <p>Background</p> <p>Infestations on cattle by the ectoparasite <it>Boophilus (Rhipicephalus) microplus </it>(cattle tick) impact negatively on animal production systems. Host resistance to tick infestation has a low to moderate heritability in the range 0.13 - 0.64 in Australia. Previous studies identified a QTL on bovine chromosome 10 (BTA10) linked to tick burden in cattle.</p> <p>Results</p> <p>To confirm these associations, we collected genotypes of 17 SNP from BTA10, including three obtained by sequencing part of the <it>ITGA11 </it>(<it>Integrin alpha 11</it>) gene. Initially, we genotyped 1,055 dairy cattle for the 17 SNP, and then genotyped 557 Brahman and 216 Tropical Composite beef cattle for 11 of the 17 SNP. In total, 7 of the SNP were significantly (<it>P </it>< 0.05) associated with tick burden tested in any of the samples. One SNP, ss161109814, was significantly (<it>P </it>< 0.05) associated with tick burden in both the taurine and the Brahman sample, but the favourable allele was different. Haplotypes for three and for 10 SNP were more significantly (<it>P </it>< 0.001) associated with tick burden than SNP analysed individually. Some of the common haplotypes with the largest sample sizes explained between 1.3% and 1.5% of the residual variance in tick burden.</p> <p>Conclusions</p> <p>These analyses confirm the location of a QTL affecting tick burden on BTA10 and position it close to the <it>ITGA11 </it>gene. The presence of a significant association in such widely divergent animals suggests that further SNP discovery in this region to detect causal mutations would be warranted.</p>http://www.biomedcentral.com/1471-2156/11/55 |
| spellingShingle | Bunch Rowan J Porto Neto Laercio R Harrison Blair E Prayaga Kishore C Barendse William Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattle BMC Genetics |
| title | Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattle |
| title_full | Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattle |
| title_fullStr | Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattle |
| title_full_unstemmed | Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattle |
| title_short | Haplotypes that include the <it>integrin alpha 11 </it>gene are associated with tick burden in cattle |
| title_sort | haplotypes that include the it integrin alpha 11 it gene are associated with tick burden in cattle |
| url | http://www.biomedcentral.com/1471-2156/11/55 |
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