Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan
Background & Objective: Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood pressure. Nitric oxide is continuously produced by endothelial cells known as a compound that plays an important role in the cardiovascular system. Also, Interleukin-17 (IL-17) is...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2020-06-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-2259-en.pdf |
| _version_ | 1827812323898687488 |
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| author | Hamideh Mozafari Mohammad Mehdi Eftekharian Ghodratollah Roshanaei Mohammad Reza Safari Gholamreza Shafiee |
| author_facet | Hamideh Mozafari Mohammad Mehdi Eftekharian Ghodratollah Roshanaei Mohammad Reza Safari Gholamreza Shafiee |
| author_sort | Hamideh Mozafari |
| collection | DOAJ |
| description | Background & Objective: Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood pressure. Nitric oxide is continuously produced by endothelial cells known as a compound that plays an important role in the cardiovascular system. Also, Interleukin-17 (IL-17) is a pro-inflammatory cytokine that can mediate protective innate immunity to pathogens or contribute to the pathogenesis of inflammatory diseases. In the current study, the plasma levels of nitric oxide and serum level of IL-7 were assessed before and after Ramadan month in fasting people, aimed at the scientific investigation of the possible preventing effects of fasting for cardiovascular disease.
Materials & Methods: The present study 61 fasting man (30-60 years old) were selected and blood samples were collected from each one day before and one day after Ramadan month. Serum levels of Nitric oxide and IL-17 were measured in two groups by ELIZA kits.
Results: The results of this study shown the serum level of nitric oxide was significantly increased in individuals before and after Ramadan month (from 16.17 ± 1.15 mmol/L to 22.17 ± 1.46 mmol/L, respectively) (P<0.0001). Also, the results indicate that serum level of IL-17 was statistically different in two groups (from 58.25 ± 10.59 pg/ml to 15.98 ± 4.66 pg/ml, respectively) (P<0.0001).
Conclusion: The results of this study showed that nitric oxide and IL-17 levels decreased during the Ramadan month and so it can be concluded the fasting of Ramadan may have positive effects on cardiovascular and immune factors of the body. |
| first_indexed | 2024-03-11T23:17:07Z |
| format | Article |
| id | doaj.art-fa76bfbf98874b2db40e6db28a9bd42a |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:07Z |
| publishDate | 2020-06-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-fa76bfbf98874b2db40e6db28a9bd42a2023-09-20T21:27:15ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232020-06-0110221792185Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of RamadanHamideh Mozafari0Mohammad Mehdi Eftekharian1Ghodratollah Roshanaei2Mohammad Reza Safari3Gholamreza Shafiee4 Department of Anesthesiology, Faculty of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran Department of Immunology, Neurophysiology Research Center, Institute of Mental Health and Addiction, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Department of Biostatistics, Modeling of Noncommunicable Diseases Research Center, Institute of Health Sciences and Technology Research, Faculty of Health, Hamadan University of Medical Sciences, Hamadan, Iran Department of Laboratory Sciences, Faculty of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran Department of Clinical Biochemistry, Nutrition Health Research Center, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Background & Objective: Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood pressure. Nitric oxide is continuously produced by endothelial cells known as a compound that plays an important role in the cardiovascular system. Also, Interleukin-17 (IL-17) is a pro-inflammatory cytokine that can mediate protective innate immunity to pathogens or contribute to the pathogenesis of inflammatory diseases. In the current study, the plasma levels of nitric oxide and serum level of IL-7 were assessed before and after Ramadan month in fasting people, aimed at the scientific investigation of the possible preventing effects of fasting for cardiovascular disease. Materials & Methods: The present study 61 fasting man (30-60 years old) were selected and blood samples were collected from each one day before and one day after Ramadan month. Serum levels of Nitric oxide and IL-17 were measured in two groups by ELIZA kits. Results: The results of this study shown the serum level of nitric oxide was significantly increased in individuals before and after Ramadan month (from 16.17 ± 1.15 mmol/L to 22.17 ± 1.46 mmol/L, respectively) (P<0.0001). Also, the results indicate that serum level of IL-17 was statistically different in two groups (from 58.25 ± 10.59 pg/ml to 15.98 ± 4.66 pg/ml, respectively) (P<0.0001). Conclusion: The results of this study showed that nitric oxide and IL-17 levels decreased during the Ramadan month and so it can be concluded the fasting of Ramadan may have positive effects on cardiovascular and immune factors of the body.http://jabs.fums.ac.ir/article-1-2259-en.pdffastinginterleukin-17nitric oxideramadan |
| spellingShingle | Hamideh Mozafari Mohammad Mehdi Eftekharian Ghodratollah Roshanaei Mohammad Reza Safari Gholamreza Shafiee Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan Journal of Advanced Biomedical Sciences fasting interleukin-17 nitric oxide ramadan |
| title | Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan |
| title_full | Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan |
| title_fullStr | Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan |
| title_full_unstemmed | Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan |
| title_short | Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan |
| title_sort | evaluation of nitric oxide and interleukin 17 in the serum of men during the fast of ramadan |
| topic | fasting interleukin-17 nitric oxide ramadan |
| url | http://jabs.fums.ac.ir/article-1-2259-en.pdf |
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