An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles
Electrospraying has been recognized as an important technique for the production of microparticles for pharmaceutical applications. Nevertheless, the produce of poly (d,l)-lactide-co-glycolide (PLGA) microspheres with a desired size distribution remains a challenge. We conducted an empirical study,...
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MDPI AG
2019-03-01
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| Series: | Applied Sciences |
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| Online Access: | http://www.mdpi.com/2076-3417/9/6/1077 |
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| author | Ming-Yi Hsu Chu-Han Feng Yen-Wei Liu Shih-Jung Liu |
| author_facet | Ming-Yi Hsu Chu-Han Feng Yen-Wei Liu Shih-Jung Liu |
| author_sort | Ming-Yi Hsu |
| collection | DOAJ |
| description | Electrospraying has been recognized as an important technique for the production of microparticles for pharmaceutical applications. Nevertheless, the produce of poly (d,l)-lactide-co-glycolide (PLGA) microspheres with a desired size distribution remains a challenge. We conducted an empirical study, based on a fractional orthogonal design, to optimize the size distribution of electrosprayed particles. The influence of different processing factors, including PLGA concentration in the solution, volumetric flow rate of the solution, travel distance between the needle tip and the collection, voltage applied to the polymer solution, size of the needle, and type of solvent on the electrospraying of polymeric microparticles was investigated. After electrospraying, the size distribution of the PLGA particles was characterized and analyzed. Among the selected factors, the type of solvent used was the principal factor affecting the particle size of electrosprayed microspheres. Hexafluoro-2-propanol (HFIP) electrosprayed microparticles with the smallest diameter. However, hollowed particles could be seen among these microspheres. Dichloromethane (DCM) was found to electrospray microspheres with a fairly spherical geometry, while trichloromethane (TCM) electrosprayed particles with relatively rougher surfaces. Finally, the particle size of sprayed microspheres decreases somewhat with the polymer concentration and travel distance. |
| first_indexed | 2024-04-13T22:48:53Z |
| format | Article |
| id | doaj.art-fa77fe28c643429495d85e8a22799179 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-13T22:48:53Z |
| publishDate | 2019-03-01 |
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| spelling | doaj.art-fa77fe28c643429495d85e8a227991792022-12-22T02:26:17ZengMDPI AGApplied Sciences2076-34172019-03-0196107710.3390/app9061077app9061077An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) ParticlesMing-Yi Hsu0Chu-Han Feng1Yen-Wei Liu2Shih-Jung Liu3Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, Tao-Yuan 33302, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Tao-Yuan 33302, TaiwanElectrospraying has been recognized as an important technique for the production of microparticles for pharmaceutical applications. Nevertheless, the produce of poly (d,l)-lactide-co-glycolide (PLGA) microspheres with a desired size distribution remains a challenge. We conducted an empirical study, based on a fractional orthogonal design, to optimize the size distribution of electrosprayed particles. The influence of different processing factors, including PLGA concentration in the solution, volumetric flow rate of the solution, travel distance between the needle tip and the collection, voltage applied to the polymer solution, size of the needle, and type of solvent on the electrospraying of polymeric microparticles was investigated. After electrospraying, the size distribution of the PLGA particles was characterized and analyzed. Among the selected factors, the type of solvent used was the principal factor affecting the particle size of electrosprayed microspheres. Hexafluoro-2-propanol (HFIP) electrosprayed microparticles with the smallest diameter. However, hollowed particles could be seen among these microspheres. Dichloromethane (DCM) was found to electrospray microspheres with a fairly spherical geometry, while trichloromethane (TCM) electrosprayed particles with relatively rougher surfaces. Finally, the particle size of sprayed microspheres decreases somewhat with the polymer concentration and travel distance.http://www.mdpi.com/2076-3417/9/6/1077electrosprayingprocessing parametersmicroparticles |
| spellingShingle | Ming-Yi Hsu Chu-Han Feng Yen-Wei Liu Shih-Jung Liu An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles Applied Sciences electrospraying processing parameters microparticles |
| title | An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles |
| title_full | An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles |
| title_fullStr | An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles |
| title_full_unstemmed | An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles |
| title_short | An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles |
| title_sort | orthogonal model to study the effect of electrospraying parameters on the morphology of poly d l lactide co glycolide plga particles |
| topic | electrospraying processing parameters microparticles |
| url | http://www.mdpi.com/2076-3417/9/6/1077 |
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