Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress
Prolonged and heightened responses to stress are known factors that influence the development of mood disorders and cardiovascular diseases. Moreover, the coping strategies related to the experience of adverse events, i.e., resilience or the susceptibility to stress, are determinants for the individ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.781447/full |
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| author | Gessynger Morais-Silva Gessynger Morais-Silva Lucas Gomes-de-Souza Lucas Gomes-de-Souza Willian Costa-Ferreira Willian Costa-Ferreira Jacqueline C. Pavan Carlos C. Crestani Carlos C. Crestani Marcelo T. Marin Marcelo T. Marin |
| author_facet | Gessynger Morais-Silva Gessynger Morais-Silva Lucas Gomes-de-Souza Lucas Gomes-de-Souza Willian Costa-Ferreira Willian Costa-Ferreira Jacqueline C. Pavan Carlos C. Crestani Carlos C. Crestani Marcelo T. Marin Marcelo T. Marin |
| author_sort | Gessynger Morais-Silva |
| collection | DOAJ |
| description | Prolonged and heightened responses to stress are known factors that influence the development of mood disorders and cardiovascular diseases. Moreover, the coping strategies related to the experience of adverse events, i.e., resilience or the susceptibility to stress, are determinants for the individual risk of developing such diseases. Susceptible rats to the social defeat stress (SDS), identified by the social interaction test (SIT), show behavioral and cardiovascular alterations after SDS exposure that are not found in resilient rats. However, it is not elucidated yet how the cardiovascular system of susceptible and resilient phenotypes responds to a new stressor after SDS exposure. Thus, using the SDS exposure followed by the SIT, we evaluated heart rate, blood pressure (BP), tail skin temperature, and circulating corticosterone responses to an acute session of restraint stress in susceptible and resilient rats to SDS. Susceptible rats showed resting tachycardia and exaggerated BP response to restraint stress, while resilient rats did not present such alterations. In contrast, both phenotypes showed increased plasma corticosterone and a drop in tail skin temperature to restraint stress, which was similar to that observed in control animals. Our results revealed an increased cardiovascular reactivity in response to a new stressful stimulus in susceptible rats, which might be related to a greater risk for the development of cardiovascular diseases. |
| first_indexed | 2024-12-13T03:35:02Z |
| format | Article |
| id | doaj.art-fa794cda9b204161b52cacd9dedd480d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T03:35:02Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fa794cda9b204161b52cacd9dedd480d2022-12-22T00:01:04ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-02-011210.3389/fphys.2021.781447781447Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat StressGessynger Morais-Silva0Gessynger Morais-Silva1Lucas Gomes-de-Souza2Lucas Gomes-de-Souza3Willian Costa-Ferreira4Willian Costa-Ferreira5Jacqueline C. Pavan6Carlos C. Crestani7Carlos C. Crestani8Marcelo T. Marin9Marcelo T. Marin10Laboratory of Pharmacology, School of Pharmaceutical Sciences of Araraquara, São Paulo State University, Araraquara, BrazilJoint Graduate Program in Physiological Sciences (PIPGCF), UFSCar/UNESP, Araraquara, BrazilLaboratory of Pharmacology, School of Pharmaceutical Sciences of Araraquara, São Paulo State University, Araraquara, BrazilJoint Graduate Program in Physiological Sciences (PIPGCF), UFSCar/UNESP, Araraquara, BrazilLaboratory of Pharmacology, School of Pharmaceutical Sciences of Araraquara, São Paulo State University, Araraquara, BrazilJoint Graduate Program in Physiological Sciences (PIPGCF), UFSCar/UNESP, Araraquara, BrazilLaboratory of Pharmacology, School of Pharmaceutical Sciences of Araraquara, São Paulo State University, Araraquara, BrazilLaboratory of Pharmacology, School of Pharmaceutical Sciences of Araraquara, São Paulo State University, Araraquara, BrazilJoint Graduate Program in Physiological Sciences (PIPGCF), UFSCar/UNESP, Araraquara, BrazilLaboratory of Pharmacology, School of Pharmaceutical Sciences of Araraquara, São Paulo State University, Araraquara, BrazilJoint Graduate Program in Physiological Sciences (PIPGCF), UFSCar/UNESP, Araraquara, BrazilProlonged and heightened responses to stress are known factors that influence the development of mood disorders and cardiovascular diseases. Moreover, the coping strategies related to the experience of adverse events, i.e., resilience or the susceptibility to stress, are determinants for the individual risk of developing such diseases. Susceptible rats to the social defeat stress (SDS), identified by the social interaction test (SIT), show behavioral and cardiovascular alterations after SDS exposure that are not found in resilient rats. However, it is not elucidated yet how the cardiovascular system of susceptible and resilient phenotypes responds to a new stressor after SDS exposure. Thus, using the SDS exposure followed by the SIT, we evaluated heart rate, blood pressure (BP), tail skin temperature, and circulating corticosterone responses to an acute session of restraint stress in susceptible and resilient rats to SDS. Susceptible rats showed resting tachycardia and exaggerated BP response to restraint stress, while resilient rats did not present such alterations. In contrast, both phenotypes showed increased plasma corticosterone and a drop in tail skin temperature to restraint stress, which was similar to that observed in control animals. Our results revealed an increased cardiovascular reactivity in response to a new stressful stimulus in susceptible rats, which might be related to a greater risk for the development of cardiovascular diseases.https://www.frontiersin.org/articles/10.3389/fphys.2021.781447/fullsocial defeat stressdepressionrestraint stressheart rateblood pressureresilience |
| spellingShingle | Gessynger Morais-Silva Gessynger Morais-Silva Lucas Gomes-de-Souza Lucas Gomes-de-Souza Willian Costa-Ferreira Willian Costa-Ferreira Jacqueline C. Pavan Carlos C. Crestani Carlos C. Crestani Marcelo T. Marin Marcelo T. Marin Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress Frontiers in Physiology social defeat stress depression restraint stress heart rate blood pressure resilience |
| title | Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress |
| title_full | Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress |
| title_fullStr | Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress |
| title_full_unstemmed | Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress |
| title_short | Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress |
| title_sort | cardiovascular reactivity to a novel stressor differences on susceptible and resilient rats to social defeat stress |
| topic | social defeat stress depression restraint stress heart rate blood pressure resilience |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.781447/full |
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