Molecular epidemiology of tuberculosis in northern Australia
Australia has one of the lowest rates of tuberculosis (TB) globally; however, the rates of TB in the Northern Territory (NT) Top End and in Far North Queensland are consistently higher than the national average. Genomic sequencing of Mycobacterium tuberculosis (MTB) is increasingly being implemented...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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CSIRO Publishing
2022-01-01
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| Series: | Microbiology Australia |
| Subjects: | |
| Online Access: | https://www.publish.csiro.au/ma/pdf/MA22037 |
| _version_ | 1798004474921353216 |
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| author | Arnold Bainomugisa Ella M. Meumann |
| author_facet | Arnold Bainomugisa Ella M. Meumann |
| author_sort | Arnold Bainomugisa |
| collection | DOAJ |
| description | Australia has one of the lowest rates of tuberculosis (TB) globally; however, the rates of TB in the Northern Territory (NT) Top End and in Far North Queensland are consistently higher than the national average. Genomic sequencing of Mycobacterium tuberculosis (MTB) is increasingly being implemented for transmission surveillance and antimicrobial resistance prediction. Genomic epidemiological studies in northern Australia have demonstrated the utility of sequencing for tracking TB transmission. In the NT Top End, this has demonstrated that most TB transmission is occurring in remote regions, with recent transmission and reactivation from latency contributing to incident TB. In Far North Queensland, genomics has been used to track transmission of a multidrug-resistant MTB clone across the Torres Strait. The next steps include implementation of MTB genomic sequencing in jurisdictional laboratories with real-time cross-jurisdictional analysis to inform public health management of TB. |
| first_indexed | 2024-04-11T12:25:20Z |
| format | Article |
| id | doaj.art-fa7aaba26fa3458aafa28ba899864cd7 |
| institution | Directory Open Access Journal |
| issn | 1324-4272 2201-9189 |
| language | English |
| last_indexed | 2024-04-11T12:25:20Z |
| publishDate | 2022-01-01 |
| publisher | CSIRO Publishing |
| record_format | Article |
| series | Microbiology Australia |
| spelling | doaj.art-fa7aaba26fa3458aafa28ba899864cd72022-12-22T04:23:59ZengCSIRO PublishingMicrobiology Australia1324-42722201-91892022-01-01433117119MA22037Molecular epidemiology of tuberculosis in northern AustraliaArnold Bainomugisa0Ella M. Meumann1Queensland Mycobacteria Reference Laboratory, Pathology Queensland, Brisbane, Qld, Australia.Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.Australia has one of the lowest rates of tuberculosis (TB) globally; however, the rates of TB in the Northern Territory (NT) Top End and in Far North Queensland are consistently higher than the national average. Genomic sequencing of Mycobacterium tuberculosis (MTB) is increasingly being implemented for transmission surveillance and antimicrobial resistance prediction. Genomic epidemiological studies in northern Australia have demonstrated the utility of sequencing for tracking TB transmission. In the NT Top End, this has demonstrated that most TB transmission is occurring in remote regions, with recent transmission and reactivation from latency contributing to incident TB. In Far North Queensland, genomics has been used to track transmission of a multidrug-resistant MTB clone across the Torres Strait. The next steps include implementation of MTB genomic sequencing in jurisdictional laboratories with real-time cross-jurisdictional analysis to inform public health management of TB.https://www.publish.csiro.au/ma/pdf/MA22037epidemiologygenomicsMycobacteriumnorthern Australiapublic healthsequencing |
| spellingShingle | Arnold Bainomugisa Ella M. Meumann Molecular epidemiology of tuberculosis in northern Australia Microbiology Australia epidemiology genomics Mycobacterium northern Australia public health sequencing |
| title | Molecular epidemiology of tuberculosis in northern Australia |
| title_full | Molecular epidemiology of tuberculosis in northern Australia |
| title_fullStr | Molecular epidemiology of tuberculosis in northern Australia |
| title_full_unstemmed | Molecular epidemiology of tuberculosis in northern Australia |
| title_short | Molecular epidemiology of tuberculosis in northern Australia |
| title_sort | molecular epidemiology of tuberculosis in northern australia |
| topic | epidemiology genomics Mycobacterium northern Australia public health sequencing |
| url | https://www.publish.csiro.au/ma/pdf/MA22037 |
| work_keys_str_mv | AT arnoldbainomugisa molecularepidemiologyoftuberculosisinnorthernaustralia AT ellammeumann molecularepidemiologyoftuberculosisinnorthernaustralia |