Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis
IntroductionNumerous studies suggest that the risk of tuberculosis (TB) is linked to gene polymorphisms of the interleukin-12 receptor b subunit 1 (IL12RB1), but the association between IL12RB1 polymorphisms and TB susceptibility has not been thoroughly investigated.MethodsA meta-analysis was conduc...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1249880/full |
| _version_ | 1827376076110692352 |
|---|---|
| author | Jie Huang Qiurong He Lijun Huang Liping Liu Pei Yang Min Chen |
| author_facet | Jie Huang Qiurong He Lijun Huang Liping Liu Pei Yang Min Chen |
| author_sort | Jie Huang |
| collection | DOAJ |
| description | IntroductionNumerous studies suggest that the risk of tuberculosis (TB) is linked to gene polymorphisms of the interleukin-12 receptor b subunit 1 (IL12RB1), but the association between IL12RB1 polymorphisms and TB susceptibility has not been thoroughly investigated.MethodsA meta-analysis was conducted based on eight case-control studies with 10,112 individuals to further explore this topic. A systematic search of PubMed, Web of Science, Excerpt Medica Database, and Google Scholar up until April 6th, 2023 was performed. ORs and 95% CIs were pooled using the random-effect model. The epidemiological credibility of all significant associations was assessed using the Venice criteria and false-positive report probability (FPRP) analyses.ResultsThe IL12RB1 rs11575934 and rs401502 showed solid evidence of no significant association with TB susceptibility. However, a weak association was observed between the IL12RB1 rs375947 biomarker and pulmonary tuberculosis (PTB) susceptibility (OR = 1.64, 95% CI: 1.22, 2.21).DiscussionThese findings should be confirmed through larger, better-designed studies to clarify the relationship between biomarkers in IL12RB1 gene and different types of TB susceptibility. |
| first_indexed | 2024-03-08T12:04:20Z |
| format | Article |
| id | doaj.art-fa7ade703cae4cce83fce1500255835f |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-08T12:04:20Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-fa7ade703cae4cce83fce1500255835f2024-01-23T12:48:32ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-01-011210.3389/fpubh.2024.12498801249880Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysisJie Huang0Qiurong He1Lijun Huang2Liping Liu3Pei Yang4Min Chen5Department of Clinical Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital of Hainan Medical University, Haikou, ChinaIntroductionNumerous studies suggest that the risk of tuberculosis (TB) is linked to gene polymorphisms of the interleukin-12 receptor b subunit 1 (IL12RB1), but the association between IL12RB1 polymorphisms and TB susceptibility has not been thoroughly investigated.MethodsA meta-analysis was conducted based on eight case-control studies with 10,112 individuals to further explore this topic. A systematic search of PubMed, Web of Science, Excerpt Medica Database, and Google Scholar up until April 6th, 2023 was performed. ORs and 95% CIs were pooled using the random-effect model. The epidemiological credibility of all significant associations was assessed using the Venice criteria and false-positive report probability (FPRP) analyses.ResultsThe IL12RB1 rs11575934 and rs401502 showed solid evidence of no significant association with TB susceptibility. However, a weak association was observed between the IL12RB1 rs375947 biomarker and pulmonary tuberculosis (PTB) susceptibility (OR = 1.64, 95% CI: 1.22, 2.21).DiscussionThese findings should be confirmed through larger, better-designed studies to clarify the relationship between biomarkers in IL12RB1 gene and different types of TB susceptibility.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1249880/fullIL12RB1single-nucleotide polymorphismtuberculosismeta-analysissusceptibility |
| spellingShingle | Jie Huang Qiurong He Lijun Huang Liping Liu Pei Yang Min Chen Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis Frontiers in Public Health IL12RB1 single-nucleotide polymorphism tuberculosis meta-analysis susceptibility |
| title | Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis |
| title_full | Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis |
| title_fullStr | Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis |
| title_full_unstemmed | Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis |
| title_short | Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis |
| title_sort | discovering the link between il12rb1 gene polymorphisms and tuberculosis susceptibility a comprehensive meta analysis |
| topic | IL12RB1 single-nucleotide polymorphism tuberculosis meta-analysis susceptibility |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1249880/full |
| work_keys_str_mv | AT jiehuang discoveringthelinkbetweenil12rb1genepolymorphismsandtuberculosissusceptibilityacomprehensivemetaanalysis AT qiuronghe discoveringthelinkbetweenil12rb1genepolymorphismsandtuberculosissusceptibilityacomprehensivemetaanalysis AT lijunhuang discoveringthelinkbetweenil12rb1genepolymorphismsandtuberculosissusceptibilityacomprehensivemetaanalysis AT lipingliu discoveringthelinkbetweenil12rb1genepolymorphismsandtuberculosissusceptibilityacomprehensivemetaanalysis AT peiyang discoveringthelinkbetweenil12rb1genepolymorphismsandtuberculosissusceptibilityacomprehensivemetaanalysis AT minchen discoveringthelinkbetweenil12rb1genepolymorphismsandtuberculosissusceptibilityacomprehensivemetaanalysis |